4-Benzyloxy-3-methylbenzeneboronic acid
- CAS No.
- 338454-30-1
- Chemical Name:
- 4-Benzyloxy-3-methylbenzeneboronic acid
- Synonyms
- oxy-3-methyL;AKOS BRN-0646;4-BENZYLOXY-3-METHYLPHENYLBORONIC ACID;(4-BENZYLOXY-3-METHYL)BENZENEBORONIC ACID;4-Benzyloxy-3-methylbenzeneboronicacid96%;4-Benzyloxy-3-methylbenzeneboronic acid 96%;(3-methyl-4-phenylmethoxyphenyl)boronic acid;Boronic acid, B-[3-methyl-4-(phenylmethoxy)phenyl]-;4-Benzyloxy-3-methylbenzeneboronic acid(contains varying amounts of Anhydride);4-Benzyloxy-3-methylphenylboronic Acid (contains varying amounts of Anhydride)
- CBNumber:
- CB6723345
- Molecular Formula:
- C14H15BO3
- Molecular Weight:
- 242.08
- MDL Number:
- MFCD06409944
- MOL File:
- 338454-30-1.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 102-106 |
|---|---|
| Boiling point | 431.6±55.0 °C(Predicted) |
| Density | 1.17±0.1 g/cm3(Predicted) |
| storage temp. | Inert atmosphere,Store in freezer, under -20°C |
| form | powder to crystal |
| pka | 8.74±0.17(Predicted) |
| color | White to Almost white |
| CAS DataBase Reference | 338454-30-1(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| Hazard Codes | Xi,Xn | |||||||||
| Risk Statements | 20/21/22-36/37/38 | |||||||||
| Safety Statements | 26-36 | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 29310095 | |||||||||
| NFPA 704 |
|
4-Benzyloxy-3-methylbenzeneboronic acid price More Price(57)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | B5169 | 4-Benzyloxy-3-methylphenylboronic Acid (contains varying amounts of Anhydride) | 338454-30-1 | 1g | $64 | 2026-04-30 | Buy |
| TCI Chemical | B5169 | 4-Benzyloxy-3-methylphenylboronic Acid (contains varying amounts of Anhydride) | 338454-30-1 | 5g | $188 | 2026-04-30 | Buy |
| Apolloscientific | OR5541 | 4-Benzyloxy-3-methylbenzeneboronic acid 98% | 338454-30-1 | 250mg | $21 | 2026-06-04 | Buy |
| Apolloscientific | OR5541 | 4-Benzyloxy-3-methylbenzeneboronic acid 98% | 338454-30-1 | 1g | $24 | 2026-06-04 | Buy |
| Apolloscientific | OR5541 | 4-Benzyloxy-3-methylbenzeneboronic acid 98% | 338454-30-1 | 5g | $52 | 2026-06-04 | Buy |
4-Benzyloxy-3-methylbenzeneboronic acid Chemical Properties,Uses,Production
Uses
suzuki reaction
Synthesis
338454-32-3
338454-30-1
General procedure for the synthesis of 4-benzyloxy-3-methylbenzeneboronic acid from 2-benzyloxy-5-bromotoluene: 4-bromo-1-benzyloxy-2-methylbenzene (6.9 g, 25 mmol) was dissolved in molecularly sieve-dried tetrahydrofuran (37.5 mL) and the solution was cooled to -78 °C. A n-hexane solution of 1.6 M n-butyllithium (17 mL, 27.5 mmol) was added slowly and dropwise over a period of 30 min, keeping the reaction temperature from exceeding -70 °C. After continued stirring at this temperature for 10 min, trimethyl borate (8.3 mL, 75 mmol) was added dropwise over 25 min below -70 °C. The reaction mixture was allowed to warm slowly to room temperature and stirred overnight. The reaction mixture was then cooled to 0 °C and aqueous 1 N hydrochloric acid was added dropwise. The reaction mixture was diluted with water and ethyl acetate to separate the organic and aqueous phases, and the aqueous phase was then extracted with ethyl acetate. The organic phases were combined, washed sequentially with water and saturated aqueous sodium chloride solution, dried with magnesium sulfate, filtered and concentrated. 4-Benzyloxy-3-methylphenylboronic acid 3.95 g (yield 65%) was obtained as a white powder. Mass spectrum (ISN): 301.2 (M-H)-.
References
[1] Patent: US6821980, 2004, B1. Location in patent: Page column 28
[2] Chemistry - A European Journal, 2000, vol. 6, # 20, p. 3821 - 3837
4-Benzyloxy-3-methylbenzeneboronic acid Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| T&W GROUP | 021-61551611 13296011611 | contact@trustwe.com | China | 9884 | 58 |
| Shanghai Topbiochem Technology Co., Ltd | 021-58170097 | info@topbiochem.com | China | 9513 | 58 |
| TOKYO CHEMICAL INDUSTRY CO., LTD. | 03-36680489 | Sales-JP@TCIchemicals.com | Japan | 28364 | 80 |
| TCI Europe | 320-37350700 | sales@tcieurope.eu | Europe | 23654 | 75 |
| TCI AMERICA | 800-4238616 | sales@tciamerica.com | Americas | 23636 | 75 |
| Shanghai Aladdin Bio-Chem Technology Co.,LTD | 400-6206333 13167063860 | anhua.mao@aladdin-e.com | China | 29985 | 65 |
| Supplier | Advantage |
|---|---|
| J & K SCIENTIFIC LTD. | 76 |
| Alfa Aesar | 84 |
| Energy Chemical | 61 |
| Wuhan Chemwish Technology Co., Ltd | 56 |
| T&W GROUP | 58 |
| Shanghai Topbiochem Technology Co., Ltd | 58 |
| TOKYO CHEMICAL INDUSTRY CO., LTD. | 80 |
| TCI Europe | 75 |
| TCI AMERICA | 75 |
| Shanghai Aladdin Bio-Chem Technology Co.,LTD | 65 |
View Lastest Price from 4-Benzyloxy-3-methylbenzeneboronic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2019-07-06 | 4-Benzyloxy-3-methylbenzeneboronic acid
338454-30-1
|
$1.00 | 1KG | 97%-99% | 1kg; 5kg; 100kg | Career Henan Chemical Co |
-
- 4-Benzyloxy-3-methylbenzeneboronic acid
338454-30-1
- $1.00
- 97%-99%
- Career Henan Chemical Co
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