2-(2-Hydroxyethyl)pyridine
- CAS No.
- 103-74-2
- Chemical Name:
- 2-(2-Hydroxyethyl)pyridine
- Synonyms
- 2-PYRIDINEETHANOL;2-(Pyridin-2-yl)ethan-1-ol;PYRIDINE-2-ETHANOL;2-ETHANOLPYRIDINE;Betahistine Impurity B;2-PYRIDYLETHANOL;2-Pyridinethanol;2-Pyridineethonl;2-Pyridien ethanol;P-nitrochlorobenzen
- CBNumber:
- CB6723385
- Molecular Formula:
- C7H9NO
- Molecular Weight:
- 123.15
- MDL Number:
- MFCD00006364
- MOL File:
- 103-74-2.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | -8--7°C |
|---|---|
| Boiling point | 114-116 °C/9 mmHg (lit.) |
| Density | 1.093 g/mL at 25 °C (lit.) |
| vapor pressure | 1.16-14.1Pa at 25℃ |
| refractive index |
n |
| Flash point | 199 °F |
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | Soluble in Chloroform (Slightly), Methanol (Slightly). |
| form | Liquid |
| pka | 14.49±0.10(Predicted) |
| color | Clear yellow to brown |
| PH | 8-9 (100g/l, H2O, 20℃) |
| Water Solubility | soluble |
| Sensitive | Hygroscopic |
| BRN | 111205 |
| Henry's Law Constant | 6.6×104 mol/(m3Pa) at 25℃, HSDB (2015) |
| InChI | 1S/C7H9NO/c9-6-4-7-3-1-2-5-8-7/h1-3,5,9H,4,6H2 |
| InChIKey | BXGYBSJAZFGIPX-UHFFFAOYSA-N |
| SMILES | OCCc1ccccn1 |
| LogP | 0.38 |
| CAS DataBase Reference | 103-74-2(CAS DataBase Reference) |
| EWG's Food Scores | 1 |
| FDA UNII | 4G94J9B8JR |
| NIST Chemistry Reference | 2-Pyridineethanol(103-74-2) |
| EPA Substance Registry System | 2-Pyridineethanol (103-74-2) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H319 | |||||||||
| Precautionary statements | P264-P280-P305+P351+P338-P337+P313 | |||||||||
| PPE | Eyeshields, Gloves, type ABEK (EN14387) respirator filter | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36-24/25 | |||||||||
| WGK Germany | 2 | |||||||||
| RTECS | UT2970450 | |||||||||
| F | 3 | |||||||||
| TSCA | TSCA listed | |||||||||
| HS Code | 29333999 | |||||||||
| Storage Class | 10 - Combustible liquids | |||||||||
| Hazard Classifications | Eye Irrit. 2 | |||||||||
| Hazardous Substances Data | 103-74-2(Hazardous Substances Data) | |||||||||
| REACH Registrations | Active | |||||||||
| NFPA 704 |
|
2-(2-Hydroxyethyl)pyridine price More Price(38)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 128643 | 2-Pyridineethanol 98% | 103-74-2 | 5g | $62.2 | 2026-04-30 | Buy |
| Sigma-Aldrich | 128643 | 2-Pyridineethanol 98% | 103-74-2 | 100g | $143 | 2026-04-30 | Buy |
| TCI Chemical | H0246 | 2-Pyridineethanol >98.0%(GC)(T) | 103-74-2 | 25mL | $18 | 2026-04-30 | Buy |
| TCI Chemical | H0246 | 2-Pyridineethanol >98.0%(GC)(T) | 103-74-2 | 500mL | $149 | 2026-04-30 | Buy |
| TRC | TRC-P991520-5G | 2-Pyridineethanol >95%(HPLC) | 103-74-2 | 5g | $81 | 2026-06-03 | Buy |
2-(2-Hydroxyethyl)pyridine Chemical Properties, Uses, Production
Chemical Properties
clear yellow to brown liquid
Uses
2-Pyridineethanol is a metabolite of the anti-vertigo drug Betahistine (B324000).
Uses
2-(2-Hydroxyethyl)pyridine is a metabolite of the anti-vertigo drug Betahistine. It acts as a reagent for protection of the 5'-phosphate of nucleotides as 2-pyridylethyl (Pet) esters. It is used for carboxyl protection of amino acids. It is also used to cleave such groups as Boc and Fmoc, and also to hydrogenolysis. It was used to prepare mononuclear nickel(II) acetate.
General Description
2-(2-pyridyl)ethanol derivatives react with the aryl and alkenyl chlorides (palladium-catalyzed reactions) that result in the substitution of the chloro moieties with a 2-pyridylmethyl group.
Synthesis
4377-33-7
50-00-0
103-74-2
The general procedure for the synthesis of 2-hydroxyethylpyridine from 2-chloromethylpyridine and formaldehyde is as follows: a two-necked Schlenk flask equipped with a magnetic stirring bar and a septum is heated under high vacuum with a hot air gun (ca. 400 °C) for 10 minutes. After cooling to room temperature, the flask was rinsed with argon (3 times). Zinc powder (654 mg, 2.0 equiv, 10.0 mmol) and THF (20 mL) were added sequentially. 1,2-dibromoethane (5 mol%) was added and the reaction mixture was heated to boiling. After cooling to room temperature, chlorotrimethylsilane (1 mol %) was added and the mixture was heated again to boiling. The flask was cooled to room temperature again, a solution of 2-chloromethylpyridine (633 mg, 5.0 mmol, 1 eq.) in THF (10 mL) was added and heated at 70 °C for 2 hours and then cooled to room temperature. Paraformaldehyde (450 mg, 3.0 eq, 15.0 mmol) was slowly added at room temperature and the flask was heated at 70 °C again for 6 hours. The reaction solution was cooled to room temperature and saturated NH4Cl solution was added. The phases were separated and the aqueous layer was extracted with ethyl acetate (100 mL). The organic layers were combined, washed sequentially with water (20 mL) and brine (10 mL) and dried over Na2SO4. The solvent was evaporated under reduced pressure and the residue was purified by silica gel column chromatography using cyclohexane or cyclohexane/ethyl acetate as eluent to give 2-hydroxyethylpyridine (510 mg, 83%) as a colorless liquid.
References
[1] Synthetic Communications, 2017, vol. 47, # 10, p. 968 - 974
2-(2-Hydroxyethyl)pyridine Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
1of2
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Tai 'an Huanyu Chemical Co., LTD | 13176825516; 13176825516 | 78995114@qq.com | China | 79 | 58 |
| Henan Evonik Biotechnology Co. LTD | 15672878902 | hnyingchuang@163.com | China | 4048 | 58 |
| SHANGHAI BANGCHENG CHEMICAL Co.,Ltd. | 021-69106960 13701823997 | 13701823733@163.com | China | 4634 | 60 |
| Fuyang Sineva Pharmaceutical Co., Ltd | 13866224493 | dingzhikui@sineva.com.cn | China | 27 | 58 |
| Wuhan haorong Biotechnology Co., Ltd | 13217229939 | 773651767@qq.com | China | 4498 | 58 |
| Shanghai Junren Biotechnology Co., Ltd | 18217672758 | 30575863@qq.com | China | 17 | 58 |
| NINGBO INNO PHARMCHEM CO.,LTD. | 15558396803 | sales@nbinno.com | China | 135 | 58 |
| Shandong Lifan Chemical Co. LTD | 17661223836 | 896889070@qq.com | China | 97 | 58 |
| Chizhou Blue Sky Chemical Co., Ltd. | 15996471730 | 3866853055@qq.com | China | 24 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
View Latest Price from 2-(2-Hydroxyethyl)pyridine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-10 | 2-(2-Hydroxyethyl)pyridine
103-74-2
|
$46.00-138.00 | 99.90% | 10g | TargetMol Chemicals Inc. | ||
 |
2026-09-10 | 2-(2-Hydroxyethyl)pyridine
103-74-2
|
$46.00-138.00 | 99.90% | 10g | TargetMol Chemicals Inc. | ||
 |
2026-06-30 | 2-(2-Hydroxyethyl)pyridine
103-74-2
|
1KG | 98.0% | 10000KGS | Shaanxi Dideu New Materials Co. Ltd |
-
- 2-(2-Hydroxyethyl)pyridine
103-74-2
- $46.00-138.00
- 99.90%
- TargetMol Chemicals Inc.
-
- 2-(2-Hydroxyethyl)pyridine
103-74-2
- $46.00-138.00
- 99.90%
- TargetMol Chemicals Inc.
-
- 2-(2-Hydroxyethyl)pyridine
103-74-2
- 98.0%
- Shaanxi Dideu New Materials Co. Ltd
