BMY 45778
- CAS No.
- 152575-66-1
- Chemical Name:
- BMY 45778
- Synonyms
- BMY 45778;BMY 45778 >=98% (HPLC);[3-(4,5-DIPHENYL[2,4'-BIOXAZOL]-5'-YL)PHENOXY]ACETIC ACID;Acetic acid, 2-[3-(4,5-diphenyl[2,4'-bioxazol]-5'-yl)phenoxy]-
- CBNumber:
- CB6723653
- Molecular Formula:
- C26H18N2O5
- Molecular Weight:
- 438.43
- MDL Number:
- MFCD00917043
- MOL File:
- 152575-66-1.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Boiling point | 659.9±65.0 °C(Predicted) |
|---|---|
| Density | 1.298±0.06 g/cm3(Predicted) |
| storage temp. | room temp |
| solubility | ≥67.6 mg/mL in DMSO |
| form | powder |
| pka | 3.10±0.10(Predicted) |
| color | white to beige |
| InChI | 1S/C26H18N2O5/c29-21(30)15-31-20-13-7-12-19(14-20)24-23(27-16-32-24)26-28-22(17-8-3-1-4-9-17)25(33-26)18-10-5-2-6-11-18/h1-14,16H,15H2,(H,29,30) |
| InChIKey | DSRSEEYZGWTODH-UHFFFAOYSA-N |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
BMY 45778 price More Price(19)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | BM0032 | BMY 45778 ≥98% (HPLC) | 152575-66-1 | 25mg | $402 | 2022-05-15 | Buy |
| Biosynth | FB137627 | BMY 45778 | 152575-66-1 | 5mg | $277.35 | 2026-06-04 | Buy |
| Biosynth | FB137627 | BMY 45778 | 152575-66-1 | 10mg | $471.5 | 2026-06-04 | Buy |
| Biosynth | FB137627 | BMY 45778 | 152575-66-1 | 25mg | $943 | 2026-06-04 | Buy |
| ChemScene | CS-0029177 | BMY 45778 98.98% | 152575-66-1 | 5mg | $200 | 2026-06-04 | Buy |
BMY 45778 Chemical Properties, Uses, Production
Uses
BMY 45778 is an agonist for IP receptor to up-regulate the expression of C/EBPβ and C/EBPδ.
Definition
ChEBI: BMY 45778 is a bisoxazole. It has a role as a partial prostacyclin agonist.
Biological Activity
Non-prostanoid prostacyclin mimetic that acts as a partial agonist at IP 1 prostacyclin receptors. Potently inhibits platelet aggregation in vitro (IC 50 = 27-35 nM).
Biochem/physiol Actions
BMY 45778 is a non-prostanoid prostacyclin agonist.
References
[1]. seiler sm, brassard cl, federici me, et al. [3-[4-(4,5-diphenyl-2-oxazolyl)-5-oxazolyl]phenoxy]acetic acid (bmy 45778) is a potent non-prostanoid prostacyclin partial agonist: effects on platelet aggregation, adenylyl cyclase, camp levels, protein kinase, and iloprost binding. prostaglandins, 1997, 53(1): 21-35.
[2]. wise h, qian ym, jones rl. a study of prostacyclin mimetics distinguishes neuronal from neutrophil ip receptors. eur j pharmacol, 1995, 278(3): 265-269.
BMY 45778 Preparation Products And Raw materials
Raw materials
Preparation Products
BMY 45778 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 18930552037 | 3bsc@sina.com | China | 15813 | 69 |
| Guangzhou Isun Pharmaceutical Co., Ltd | 020-39119399 18927568969 | isunpharm@qq.com | China | 4773 | 55 |
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51389 | 80 |
| EMMX Biotechnology LLC | 888-539-0666 | info@emmx.com | United States | 8435 | 60 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
| BOC Sciences | 16314854226; +8616314854226 | inquiry@bocsci.com | United States | 19852 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 +86-13203830695 | laboratory@coreychem.com | China | 30203 | 58 |
| Energy Chemical | 021-58432009 400-005-6266 | marketing@energy-chemical.com | China | 44871 | 58 |
| Jinan Jiuli Biotechnology Co. , Ltd. | 15865264761 | 486064515@qq.com | China | 4999 | 58 |
| Shanghai Tachizaki Biomedical Research Center | 18014399201 | sales@chemlab-tachizaki.com | China | 2934 | 58 |
