3-Phenylamino-propionic acid
- CAS No.
- 5652-38-0
- Chemical Name:
- 3-Phenylamino-propionic acid
- Synonyms
- 3-(PHENYLAMINO)PROPANOIC ACID;N-Phenyl-b-alanine;N-PHENYL-BETA-ALANINE;NSC 54626;3-(Phenylamino);RARECHEM AL BO 0162;β-Alanine, N-phenyl-;3-Anilinopropionic acid;3-Anilinopropanoic acid;3-Phenylammoniopropanoate
- CBNumber:
- CB6740092
- Molecular Formula:
- C9H11NO2
- Molecular Weight:
- 165.19
- MDL Number:
- MFCD00089905
- MOL File:
- 5652-38-0.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| HS Code | 2922498590 |
3-Phenylamino-propionic acid price More Price(36)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biosynth | FAA65238 | 3-Phenylamino-propionic acid | 5652-38-0 | 10g | $472 | 2026-06-04 | Buy |
| Apolloscientific | OR965638 | 3-Phenylamino-propionic acid 95% | 5652-38-0 | 1g | $59 | 2026-06-04 | Buy |
| Apolloscientific | OR965638 | 3-Phenylamino-propionic acid 95% | 5652-38-0 | 5g | $120 | 2026-06-04 | Buy |
| Activate Scientific | AS25954 | 3-Anilinopropanoic Acid 95% | 5652-38-0 | 1g | $43 | 2026-06-04 | Buy |
| Activate Scientific | AS25954 | 3-Anilinopropanoic Acid 95% | 5652-38-0 | 5g | $127 | 2026-06-04 | Buy |
3-Phenylamino-propionic acid Chemical Properties, Uses, Production
Uses
3-(Phenylamino)propanoic Acid is used in the preparation of spiroheterocycles as filamin A (FLNA) binding antiinflammatory analgesics.
Synthesis
57-57-8
62-53-3
5652-38-0
The general procedure for the synthesis of 3-anilinopropionic acid from β-propiolactone and aniline was as follows: aniline (5.00 g) was dissolved in acetonitrile (30 ml) and heated to reflux. Subsequently, β-propiolactone (3.36 ml) was added slowly and dropwise. The reflux condition was maintained and the reaction was continued for 3 hours. After completion of the reaction, the solvent was removed by distillation under reduced pressure. The residue was dissolved in aqueous sodium hydroxide solution and the aqueous phase was washed with ether. The pH of the aqueous phase was adjusted to 4-5 with hydrochloric acid and subsequently extracted with ether. The organic layers were combined, washed sequentially with water and saturated saline, and dried over anhydrous sodium sulfate. After filtration, the organic phase was concentrated under reduced pressure. Finally, the residue was purified by silica gel column chromatography (eluent ratio of chloroform:methanol=9:1) to afford the target product 3-anilinopropionic acid (2.08 g, 23% yield).
References
[1] Patent: EP1452526, 2004, A1. Location in patent: Page 105
[2] Journal of the American Chemical Society, 1951, vol. 73, p. 3168,3171
[3] Patent: US2008/153871, 2008, A1. Location in patent: Page/Page column 24
3-Phenylamino-propionic acid Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| Shanghai Sunway Pharmaceutical Technology Co., Ltd | 13761987713 | hxzheng@sunwaypharm.cn | China | 8663 | 57 |
| Taizhou Tongxin Bio-Tech Co., Ltd | 0523-86818997 18652728585 | sales@allyrise.com | China | 2986 | 60 |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
| Cool Pharm, Ltd | 021-60455363 18019463053 | sales@coolpharm.com | China | 8455 | 58 |
| Shanghai GaoDao Pharmaceutical Co., Ltd. | 021-15001867143 15001867143 | 1095570358@qq.com | China | 915 | 55 |
| JW & Y Pharmlab Co., Ltd. | 021-64340559 | xinyu_shi@jwypharmlab.com.cn | China | 11999 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131885 | 58 |
| Amatek Scientific Co. Ltd. | 0512-56316828 400-867-5858;400-867-5858 | info@amateksci.com | China | 28760 | 58 |
| Aikon International Limited | 025-58859352 15955137747 | sales01@aikonchem.com | China | 16021 | 58 |
View Latest Price from 3-Phenylamino-propionic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2020-01-09 | 3-PHENYLAMINO-PROPIONIC ACID
5652-38-0
|
$2.00 | 1g | 98%min | Career Henan Chemical Co |
-
- 3-PHENYLAMINO-PROPIONIC ACID
5652-38-0
- $2.00
- 98%min
- Career Henan Chemical Co
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