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Ethanone, 1-(5-hydroxybenzo[b]thien-2-yl)-

Ethanone, 1-(5-hydroxybenzo[b]thien-2-yl)- structure

CAS No.: 56363-81-6

Chemical Name:: Ethanone, 1-(5-hydroxybenzo[b]thien-2-yl)-

Synonyms: Dual DYRK/CLK inhibitor, Cpd 23;1-(5-hydroxybenzo[b]thiophen-2-yl)ethanone;Ethanone, 1-(5-hydroxybenzo[b]thien-2-yl)-

CBNumber:: CB68290072

Molecular Formula:: C10H8O2S

Molecular Weight:: 192.23

MDL Number:

MOL File:: 56363-81-6.mol

Last updated:2026-01-13 13:16:54

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Ethanone, 1-(5-hydroxybenzo[b]thien-2-yl)- Properties

Melting point	190-191 °C(Solv: chloroform (67-66-3))
Boiling point	375.4±22.0 °C(Predicted)
Density	1.344±0.06 g/cm3(Predicted)
storage temp.	-20°C
solubility	DMSO: 50mg/mL
form	powder
pka	9.03±0.40(Predicted)
color	yellow
SMILES	O=C(C)C1=CC2=CC(O)=CC=C2S1
UNSPSC Code	12352200
NACRES	NA.77

SAFETY

Risk and Safety Statements

WGK Germany	WGK 3
Storage Class	11 - Combustible Solids

Ethanone, 1-(5-hydroxybenzo[b]thien-2-yl)- price

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
aablocks	AA01B9GR	1-(5-hydroxy-1-benzothiophen-2-yl)ethan-1-one 95%	56363-81-6	100mg	$777	2026-05-29	Buy
aablocks	AA01B9GR	1-(5-hydroxy-1-benzothiophen-2-yl)ethan-1-one 95%	56363-81-6	250mg	$1065	2026-05-29	Buy
aablocks	AA01B9GR	1-(5-hydroxy-1-benzothiophen-2-yl)ethan-1-one 95%	56363-81-6	500mg	$1620	2026-05-29	Buy
aablocks	AA01B9GR	1-(5-hydroxy-1-benzothiophen-2-yl)ethan-1-one 95%	56363-81-6	1g	$2048	2026-05-29	Buy
aablocks	AA01B9GR	1-(5-hydroxy-1-benzothiophen-2-yl)ethan-1-one 95%	56363-81-6	2.5g	$3919	2026-05-29	Buy

Product number	Packaging	Price	Buy
AA01B9GR	100mg	$777	Buy
AA01B9GR	250mg	$1065	Buy
AA01B9GR	500mg	$1620	Buy
AA01B9GR	1g	$2048	Buy
AA01B9GR	2.5g	$3919	Buy

Ethanone, 1-(5-hydroxybenzo[b]thien-2-yl)- Chemical Properties, Uses, Production

Uses

A cell permeable 5-hydroxybenzothiophenylethanone that acts as a dual inhibitor of Cdc2-like kinase 1 (Clk1; IC₅₀ = 60 nM) and dual specificity tyrosine phosphorylation-regulated kinases 1A/1B (Dyrk1A/1B; IC₅₀ = 200 and 100 nM, respectively). Also inhibits Clk4 with high potency. Exhibits much reduced inhibitory effect on Haspin ( IC₅₀ = 800 nM) and has much reduced inhibitory effect on other kinases even at higher concentration (~ 5 µM). Causes a complete disappearance of incomplete and alternatively spliced transcripts and is shown to enhance the generation of the mature Clk1 mRNA splicing product (EC₅₀ = 8.9 µM) in cells.
A cell permeable, dual inhibitor of Cdc2-like kinase 1 (Clk1; IC₅₀ = 60 nM) and dual specificity tyrosine phosphorylation-regulated kinases 1A/1B (Dyrk1A/1B; IC₅₀ = 200 and 100 nM, respectively).

Biological Activity

Cell permeable: yes', 'Primary Target
DYRK/CLK

Ethanone, 1-(5-hydroxybenzo[b]thien-2-yl)- Preparation Products And Raw materials

Raw materials

Preparation Products

Ethanone, 1-(5-hydroxybenzo[b]thien-2-yl)- Suppliers

Global Suppliers ( 2)

Supplier	Tel	Email	Country	ProdList	Advantage
Zhuhai Aobokai Biomedical Technology Co., Ltd.	400-0628126	sales@aobchem.com.cn	China	19992	58

Supplier	Advantage
Zhuhai Aobokai Biomedical Technology Co., Ltd.	58

Ethanone, 1-(5-hydroxybenzo[b]thien-2-yl)- 1-(5-hydroxybenzo[b]thiophen-2-yl)ethanone Dual DYRK/CLK inhibitor, Cpd 23 56363-81-6