3-[4-(4,4,5,5-Tetramethyl-[1,3,2]dioxaborolan-2-yl)-pyrazol-1-ylmethyl]-pyridine
![3-[4-(4,4,5,5-Tetramethyl-[1,3,2]dioxaborolan-2-yl)-pyrazol-1-ylmethyl]-pyridine Structure](CAS/GIF/864754-21-2.gif)
- CAS No.
- 864754-21-2
- Chemical Name:
- 3-[4-(4,4,5,5-Tetramethyl-[1,3,2]dioxaborolan-2-yl)-pyrazol-1-ylmethyl]-pyridine
- Synonyms
- 1-(3-Pyridinmethyl)pyrazole-4-boronic acid pinacol ester;1-(3-PyridylMethyl)-1H-pyrazole-4-boronic acid pinacol ester;1-(Pyridin-3-ylmethyl)-1H-pyrazole-4-boronic acid, pinacol ester 97%;1-(Pyridin-3-ylmethyl)-1H-pyrazole-4-boronic acid pinacol ester;3-{[4-(tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl]methyl}pyridine;3-[4-(4,4,5,5-Tetramethyl-[1,3,2]dioxaborolan-2-yl)-pyrazol-1-ylmethyl]-pyridine;3-((4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)methyl)pyridine;Pyridine, 3-[[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl]methyl]-;3-((4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)methyl)pyridine - [T25839]
- CBNumber:
- CB6836681
- Molecular Formula:
- C15H20BN3O2
- Molecular Weight:
- 285.15
- MDL Number:
- MFCD08706029
- MOL File:
- 864754-21-2.mol
- MSDS File:
- SDS
| Melting point | 102-106℃ |
|---|---|
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| form | solid |
| Appearance | Off-white to yellow Solid |
| InChI | 1S/C15H20BN3O2/c1-14(2)15(3,4)21-16(20-14)13-9-18-19(11-13)10-12-6-5-7-17-8-12/h5-9,11H,10H2,1-4H3 |
| InChIKey | LVLQAPQDEZOFQU-UHFFFAOYSA-N |
| SMILES | CC(O1)(C)C(C)(C)OB1C2=CN(CC3=CC=CN=C3)N=C2 |
| UNSPSC Code | 12352106 |
| NACRES | NA.21 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264b-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P362+P364-P403+P233-P501c | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 22 | |||||||||
| WGK Germany | WGK 3 | |||||||||
| HS Code | 2933399990 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Acute Tox. 4 Oral | |||||||||
| NFPA 704 |
|
3-[4-(4,4,5,5-Tetramethyl-[1,3,2]dioxaborolan-2-yl)-pyrazol-1-ylmethyl]-pyridine price More Price(34)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | BML00215 | 1-(Pyridin-3-ylmethyl)-1H-pyrazole-4-boronic acid pinacol ester Aldrich | 864754-21-2 | 1g | $454 | 2026-04-30 | Buy |
| Apolloscientific | OR361579 | 1-(Pyridin-3-ylmethyl)-1H-pyrazole-4-boronic acid, pinacol ester 97% | 864754-21-2 | 250mg | $21 | 2026-06-04 | Buy |
| Matrix Scientific | 307524 | 3-((4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)methyl)pyridine | 864754-21-2 | 250.00mg | $19 | 2026-05-19 | Buy |
| Matrix Scientific | 307524 | 3-((4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)methyl)pyridine | 864754-21-2 | 1.00g | $69 | 2026-05-19 | Buy |
| Matrix Scientific | 307524 | 3-((4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)methyl)pyridine | 864754-21-2 | 5.00g | $330 | 2026-05-19 | Buy |
3-[4-(4,4,5,5-Tetramethyl-[1,3,2]dioxaborolan-2-yl)-pyrazol-1-ylmethyl]-pyridine Chemical Properties, Uses, Production
Synthesis
69966-55-8
269410-08-4
![3-[4-(4,4,5,5-TETRAMETHYL-[1,3,2]DIOXABOROLAN-2-YL)-PYRAZOL-1-YLMETHYL]-PYRIDINE](/CAS/GIF/864754-21-2.gif)
864754-21-2
The general procedure for the synthesis of 1-(3-pyridinylmethyl)-1H-pyrazole-4-boronic acid pinacol ester from 3-bromomethylpyridine and 4-pyrazole boronic acid pinacol ester was as follows: 3-bromomethylpyridine (2.67 g, 15.5 mmol) and 4-pyrazole boronic acid pinacol ester (3.01 g, 15.5 mmol) were dissolved in N,N-dimethylformamide (DMF, 20 mL). ) in N,N-dimethylformamide (DMF, 20 mL), followed by addition of potassium carbonate (2.2 g, 16 mmol) to the reaction system. The reaction mixture was heated to 80 °C and the reaction was stirred at this temperature for 8 hours. After completion of the reaction, the mixture was poured into water (50 mL) and extracted with ethyl acetate (50 mL x 3), the organic phases were combined and washed with saturated brine (20 mL) and dried over anhydrous sodium sulfate. After the solvent was removed by concentration under reduced pressure, the residue was purified by column chromatography (eluent: petroleum ether/ethyl acetate, v/v=1/1.5) to give 280 mg of the target product in the form of light yellow oil in 6.33% yield.
References
[1] Patent: CN106749268, 2017, A. Location in patent: Paragraph 0607; 0608
3-[4-(4,4,5,5-Tetramethyl-[1,3,2]dioxaborolan-2-yl)-pyrazol-1-ylmethyl]-pyridine Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| Jiangsu Aikon Biopharmaceutical R&D co.,Ltd. | 025-66113011 13913916777 | cfzhang@aikonchem.com | China | 19902 | 55 |
| Shanghai Balmxy Pharmaceutical Co., Ltd | 021-24206007 13764915196 | sales@balmxy.com | China | 6959 | 55 |
| ShangHai AmK Pharmaceutical Technology Co., Ltd. | 微信 18019252918 18019252918 | sale@amkchem.com | China | 14982 | 55 |
| Shanghai Rong Lin Medical Technology Co., Ltd. | 18602194589 | lincy-110@163.com | China | 873 | 58 |
| Cool Pharm, Ltd | 021-60455363 18019463053 | sales@coolpharm.com | China | 8455 | 58 |
| Wuhan Chemwish Technology Co.， Ltd | 027-67849912 | sales@chemwish.com | China | 9144 | 60 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131885 | 58 |
