β-Aminoarteether maleate
- CAS No.
- 133162-25-1
- Chemical Name:
- β-Aminoarteether maleate
- Synonyms
- β-Aminoarteether maleate
- CBNumber:
- CB69273067
- Molecular Formula:
- C21H33NO9
- Molecular Weight:
- 443.49
- MDL Number:
- MOL File:
- 133162-25-1.mol
β-Aminoarteether maleate Chemical Properties, Uses, Production
Uses
β-Aminoarteether maleate (SM934) is an Artemisinin derivative with orally active. β-Aminoarteether maleate can be used for inflammation and autoimmune disease research, such as lupus diseases[1].
in vivo
β-Aminoarteether (SM934; 1-10 mg/kg; oral administration; daliy; for 3 months) treatment significantly delays the progression of glomerulonephritis and increases the survival rate of NZB/W F1 mice. β-Aminoarteether treatment promots the IL-10 production of macrophages from NZB/W F1 mice[1].
| Animal Model: | Female NZB/W F1 mice (Six and half months old)[1] |
| Dosage: | 1 mg/kg, 3 mg/kg, and 10 mg/kg |
| Administration: | Oral administration; daliy; for 3 months |
| Result: | Significantly delayed the progression of glomerulonephritis and increased the survival rate of NZB/W F1 mice. |
References
[1] Li-Fei Hou, et al. SM934 treated lupus-prone NZB × NZW F1 mice by enhancing macrophage interleukin-10 production and suppressing pathogenic T cell development. PLoS One. 2012;7(2):e32424. DOI:10.1371/journal.pone.0032424
[2] Yang FM, Fan D, Yang XQ, et al. The artemisinin analog SM934 alleviates dry eye disease in rodent models by regulating TLR4/NF-κB/NLRP3 signaling. Acta Pharmacol Sin. 2021;42(4):593-603. DOI:10.1038/s41401-020-0484-5
β-Aminoarteether maleate Preparation Products And Raw materials
Raw materials
Preparation Products
β-Aminoarteether maleate Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 29874 | 58 |
| Supplier | Advantage |
|---|---|
| TargetMol Chemicals Inc. | 58 |
