ChemicalBook >> CAS DataBase List >>hydrocotarnine
hydrocotarnine
- CAS No.
- 550-10-7
- Chemical Name:
- hydrocotarnine
- Synonyms
- 8-Methoxy-2-methyl-6,7-methylenedioxy-1,2,3,4-tetrahydroisoquinoline;Hydrocotarnine Hydrochloride;hydrocotarnine, 10 mM in DMSO;Noscapine Impurity 3(Hydrocotarnine);4-methoxy-6-methyl-2H,5H,6H,7H,8H-[1,3]dioxolo[4,5-g]isoquinoline;5,6,7,8-Tetrahydro-4-methoxy-6-methyl-1,3-dioxolo[4,5-g]isoquinoline;4-Methoxy-6-methyl-5,6,7,8-tetrahydro-1,3-dioxolo[4,5-g]isoquinoline;1,3-Dioxolo[4,5-g]isoquinoline, 5,6,7,8-tetrahydro-4-methoxy-6-methyl-;1,2,3,4-Tetrahydro-2-methyl-6,7-(methylenebisoxy)-8-methoxyisoquinoline;4-methoxy-6-methyl-7,8-dihydro-5H-[1,3]dioxolo[4,5-g]isoquinoline hydrate hydrochloride
- CBNumber:
- CB6930118
- Molecular Formula:
- C12H15NO3
- Molecular Weight:
- 221.25
- MDL Number:
- MFCD00868501
- MOL File:
- 550-10-7.mol
- MSDS File:
- SDS
Last updated:2026-08-20 20:20:01
| Melting point | 56°C |
|---|---|
| Boiling point | 362.31°C (rough estimate) |
| Density | 1.1514 (rough estimate) |
| refractive index | 1.5200 (estimate) |
| solubility | Chloroform (Slightly), Ethyl Acetate (Slightly) |
| form | Solid |
| pka | 7.75±0.20(Predicted) |
| color | Light Brown to Orange |
| FDA UNII | G22L6JNE61 |
hydrocotarnine price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | TRC-M543560-50MG | 4-Methoxy-6-methyl-5,6,7,8-tetrahydro-[1,3]dioxolo[4,5-g]isoquinoline | 550-10-7 | 50mg | $256 | 2026-06-03 | Buy |
| TRC | TRC-M543560-10MG | 4-Methoxy-6-methyl-5,6,7,8-tetrahydro-[1,3]dioxolo[4,5-g]isoquinoline | 550-10-7 | 10mg | $66 | 2026-06-03 | Buy |
| TRC | TRC-M543560-100MG | 4-Methoxy-6-methyl-5,6,7,8-tetrahydro-[1,3]dioxolo[4,5-g]isoquinoline | 550-10-7 | 100mg | $409 | 2026-06-03 | Buy |
| Biosynth | AAA55010 | 4-Methoxy-6-methyl-2H,5H,6H,7H,8H-[1,3]dioxolo[4,5-G]isoquinoline | 550-10-7 | 25mg | $189 | 2026-06-04 | Buy |
| Biosynth | AAA55010 | 4-Methoxy-6-methyl-2H,5H,6H,7H,8H-[1,3]dioxolo[4,5-G]isoquinoline | 550-10-7 | 50mg | $302.5 | 2026-06-04 | Buy |
hydrocotarnine Chemical Properties, Uses, Production
Uses
Hydrocotarnine Hydrochloride, is an oxidative degradation product of the drug Noscapine (128-62-1).
Definition
ChEBI: 4-methoxy-6-methyl-7,8-dihydro-5H-[1,3]dioxolo[4,5-g]isoquinoline is a member of isoquinolines.
in vivo
Hydrocotarnine (10 mg/kg/d; i.p.; 9 d) shows inhibitory effect on Cbl and results in increasing IL-18 levels, indicating that NLRP3 inflammasome activation is enhanced in mice[1].
Hydrocotarnine (10 mg/kg/d; i.p.; 9 d) protects mice from DSS-induced colitis, with low scores of pathological evaluation of inflammation, epithelial defects, and crypt atrophy[1].
| Animal Model: | DSS-induced colitis model in C57BL/6 mice (6-9 weeks old)[1] |
| Dosage: | 10 mg/kg |
| Administration: | Intraperitoneal injection; once daily; 9 days while 2.5% DSS treatment began on day 1 and ended on day 7 |
| Result: | Significantly attenuated the weight loss of DSS-induced colitis mice compared to PBS-treated control mice, indicating that decreasing negative regulation of the NLRP3 inflammasome activation could attenuate colitis in an animal model. |
hydrocotarnine Preparation Products And Raw materials
Raw materials
Preparation Products
hydrocotarnine Suppliers
Global Suppliers ( 30)
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Topbiochem Technology Co., Ltd | 021-58170097 | info@topbiochem.com | China | 9510 | 58 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
| Changzhou Hopschain Chemical Co.,Ltd. | 85528066 13775048983 | sales@hopschem.com | China | 31548 | 55 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| Shanghai Haohong Pharmaceutical Co., Ltd. | 400-8210725 4008210725 | malulu@leyan.com | China | 54996 | 58 |
| Nantong Hi-Future Biotechnology Co., Ltd | +86-0513; 18051384581 | sales@chemhifuture.com | China | 3075 | 58 |
| Shaanxi DIDU pharmaceutical and Chemical Co., Ltd | 029-029-81120477 17792793610 | 1033@dideu.com | China | 9990 | 58 |
| TargetMol Chemicals Inc. | 4008200310 15002144251 | marketing@tsbiochem.com | China | 24951 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 11963 | 58 |
| Shanghai?Medlife?Pharm-Tech?Co.,?Ltd | 4000862158 18117107507 | vip@med-life.cn | China | 4999 | 58 |
View Latest Price from hydrocotarnine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-20 | hydrocotarnine
550-10-7
|
$41.00-158.00 | 99.31% | 10g | TargetMol Chemicals Inc. |
-
- hydrocotarnine
550-10-7
- $41.00-158.00
- 99.31%
- TargetMol Chemicals Inc.
550-10-7 (hydrocotarnine) Related Search:
1,2,3,4-Tetrahydro-2-methyl-6,7-(methylenebisoxy)-8-methoxyisoquinoline
4-Methoxy-6-methyl-5,6,7,8-tetrahydro-1,3-dioxolo[4,5-g]isoquinoline
5,6,7,8-Tetrahydro-4-methoxy-6-methyl-1,3-dioxolo[4,5-g]isoquinoline
Hydrocotarnine Hydrochloride
4-methoxy-6-methyl-7,8-dihydro-5H-[1,3]dioxolo[4,5-g]isoquinoline hydrate hydrochloride
4-methoxy-6-methyl-2H,5H,6H,7H,8H-[1,3]dioxolo[4,5-g]isoquinoline
Noscapine Impurity 3(Hydrocotarnine)
1,3-Dioxolo[4,5-g]isoquinoline, 5,6,7,8-tetrahydro-4-methoxy-6-methyl-
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hydrocotarnine, 10 mM in DMSO
8-Methoxy-2-methyl-6,7-methylenedioxy-1,2,3,4-tetrahydroisoquinoline
550-10-7
