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Methyl 3-oxo-3,4-dihydro-2H-1,4-benzothiazine-6-carboxylate

Methyl 3-oxo-3,4-dihydro-2H-1,4-benzothiazine-6-carboxylate structure

CAS No.: 188614-01-9

Chemical Name:: Methyl 3-oxo-3,4-dihydro-2H-1,4-benzothiazine-6-carboxylate

Synonyms: Methyl-3-Oxo-3,4-Dihydro-2H-1,;Methyl 3-Oxo-2H-1,4-benzothiazine-6-carboxylate;methyl 3-oxo-4H-1,4-benzothiazine-6-carboxylate;3-oxo-4H-1,4-benzothiazine-6-carboxylic acid methyl ester;3-keto-4H-1,4-benzothiazine-6-carboxylic acid methyl ester;Methyl 3,4-dihydro-3-oxo-2H-1,4-benzothiazine-6-carboxylate;Methyl 3-oxo-3,4-dihydro-2H-1,4-benzothiazine-6-carboxylate;2-Methyl-3-oxo-3,4-dihydro-2H-1,4-benzothiazine-6-carboxylate;Methyl3-oxo-3,4-dihydro-2H-1,4-benzothiazine-6-carboxylate,97%;methyl 3-oxo-3,4-dihydro-2H-benzo[b][1,4]thiazine-6-carboxylate

CBNumber:: CB6948304

Molecular Formula:: C10H9NO3S

Molecular Weight:: 223.25

MDL Number:: MFCD00449104

MOL File:: 188614-01-9.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-05-28 01:24:28

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Methyl 3-oxo-3,4-dihydro-2H-1,4-benzothiazine-6-carboxylate Properties

Melting point	180-182°
Boiling point	435.7±45.0 °C(Predicted)
Density	1.343±0.06 g/cm3(Predicted)
storage temp.	Sealed in dry,Room Temperature
form	Solid
pka	12.34±0.20(Predicted)
Appearance	White to off-white Solid
CAS DataBase Reference	188614-01-9(CAS DataBase Reference)
UNSPSC Code	12352200

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H335

Precautionary statements

P261-P280a-P304+P340-P305+P351+P338-P405-P501a

Hazard Codes

HazardClass

IRRITANT

HS Code

2934999090

NFPA 704

	1
2		0

Methyl 3-oxo-3,4-dihydro-2H-1,4-benzothiazine-6-carboxylate price More Price(59)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Usbiological	284710	Methyl 3-oxo-3,4-dihydro-2H-1,4-benzothiazine-6-carboxylate Asreported	188614-01-9	1g	$366	2026-06-03	Buy
Usbiological	284710	Methyl 3-oxo-3,4-dihydro-2H-1,4-benzothiazine-6-carboxylate Asreported	188614-01-9	2g	$508	2026-06-03	Buy
Usbiological	284710	Methyl 3-oxo-3,4-dihydro-2H-1,4-benzothiazine-6-carboxylate Asreported	188614-01-9	5g	$975	2026-06-03	Buy
Usbiological	284710	Methyl 3-oxo-3,4-dihydro-2H-1,4-benzothiazine-6-carboxylate Asreported	188614-01-9	10g	$1397	2026-06-03	Buy
Usbiological	284710	Methyl 3-oxo-3,4-dihydro-2H-1,4-benzothiazine-6-carboxylate Asreported	188614-01-9	25g	$2031	2026-06-03	Buy

Product number	Packaging	Price	Buy
284710	1g	$366	Buy
284710	2g	$508	Buy
284710	5g	$975	Buy
284710	10g	$1397	Buy
284710	25g	$2031	Buy

Methyl 3-oxo-3,4-dihydro-2H-1,4-benzothiazine-6-carboxylate Chemical Properties,Uses,Production

Synthesis

2365-48-2

412947-54-7

Methyl 3-oxo-3,4-dihydro-2H-1,4-benzothiazine-6-carboxylate

188614-01-9

GENERAL METHOD: A suspension of methyl 3-iodo-4-aminobenzoate (1 mmol), methyl thioglycolate (1.5 eq.), cuprous(I) iodide (0.05 mmol), trans-N,N'-dimethylcyclohexane-1,2-diamine (0.1 mmol), and cesium carbonate (2 eq.) in anhydrous 1,4-dioxane (4 mL) was added to a vial. Nitrogen was passed into the suspension to degas it for 3 min under stirring. Subsequently, the vial was sealed. The reaction mixture was heated at 100 °C (oil bath temperature) for 15 hours. After completion of the reaction, it was cooled to room temperature and filtered. The filtrates were combined and concentrated using a rotary evaporator and the resulting residue was purified by silica gel column chromatography (eluent: 5% dichloromethane solution in methanol) to afford the target product, methyl 3-carbonyl-3,4-dihydro-2H-1,4-benzothiazine-6-carboxylate, as a beige solid.

References

[1] Tetrahedron Letters, 2013, vol. 54, # 38, p. 5214 - 5216

Methyl 3-oxo-3,4-dihydro-2H-1,4-benzothiazine-6-carboxylate Preparation Products And Raw materials

Raw materials

Methyl thioglycolate Methyl 3-amino-4-iodobenzoate Copper(l) iodide (1R,2R)-N,N'-Dimethyl-1,2-cyclohexanediamine 1,4-Dioxane

Cesium carbonate

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Preparation Products

Methyl 3-oxo-3,4-dihydro-2H-1,4-benzothiazine-6-carboxylate Suppliers

Global( 98)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
Capot Chemical Co., Ltd	+86 (0) 571 85 58 67 18		China	18187	66
Jia Xing Isenchem Co.,Ltd	0573-85285100 18627885956	isenchem@163.com	China	9389	66
Accela ChemBio Co.,Ltd.	021-50795510 4000665055	marketing@accelachem.com	China	10972	64
Shanghai Hanhong Scientific Co.,Ltd.	021-54306202 13764082696	info@hanhongsci.com	China	42917	64
Syntechem Co.,Ltd		info@syntechem.com	China	12973	57
China Langchem Inc.	0086-21-58956006		China	7798	57
Suzhou Sibian Chemical Technology Co.,Ltd.	0512-65617459 18915409046	sales@sibian-chem.com	China	1917	55
Shanghai Topbiochem Technology Co., Ltd	+86-21-60341587	sales@topbiochem.com	China	6166	58
Cantotech Chemicals, Ltd.	86-0755-86635001	cantotech@126.com	China	4554	55

Supplier	Advantage
J & K SCIENTIFIC LTD.	76
Capot Chemical Co., Ltd	66
Jia Xing Isenchem Co.,Ltd	66
Accela ChemBio Co.,Ltd.	64
Shanghai Hanhong Scientific Co.,Ltd.	64
Syntechem Co.,Ltd	57
China Langchem Inc.	57
Suzhou Sibian Chemical Technology Co.,Ltd.	55
Shanghai Topbiochem Technology Co., Ltd	58
Cantotech Chemicals, Ltd.	55

View Lastest Price from Methyl 3-oxo-3,4-dihydro-2H-1,4-benzothiazine-6-carboxylate manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2019-12-31	Methyl 3-oxo-3,4-dihydro-2H-1,4-benzothiazine-6-carboxylate 188614-01-9	$1.00	1KG	99%	2000KGS	Career Henan Chemical Co

Methyl 3-oxo-3,4-dihydro-2H-1,4-benzothiazine-6-carboxylate
188614-01-9
$1.00
99%
Career Henan Chemical Co

Methyl 3-oxo-3,4-dihydro-2H-1,4-benzothiazine-6-carboxylate Spectrum

Methyl 3-oxo-3,4-dihydro-2H-1,4-benzothiazine-6-carboxylate(188614-01-9)¹HNMR

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Methyl 3,4-dihydro-3-oxo-2H-benzo[b][1,4]thiazine-6-carboxylate Methyl 3-oxo-3,4-dihydro-2H-1,4-benzothiazine-6-carboxylate Methyl-3-Oxo-3,4-Dihydro-2H-1, Methyl 3,4-dihydro-3-oxo-2H-1,4-benzothiazine-6-carboxylate methyl 3-oxo-3,4-dihydro-2H-benzo[b][1,4]thiazine-6-carboxylate 2-Methyl-3-oxo-3,4-dihydro-2H-1,4-benzothiazine-6-carboxylate Methyl 3-Oxo-2H-1,4-benzothiazine-6-carboxylate 3-keto-4H-1,4-benzothiazine-6-carboxylic acid methyl ester 3-oxo-4H-1,4-benzothiazine-6-carboxylic acid methyl ester methyl 3-oxo-4H-1,4-benzothiazine-6-carboxylate JR-8617, Methyl 3,4-dihydro-3-oxo-2H-benzo[b][1,4]thiazine-6-carboxylate, 97% 2H-1,4-Benzothiazine-6-carboxylic acid, 3,4-dihydro-3-oxo-, methyl ester Methyl3-oxo-3,4-dihydro-2H-1,4-benzothiazine-6-carboxylate,97% 188614-01-9 Fused Ring Systems Heterocycle intermediates Esters API intermediates