|
|
| | Methyl 3-oxo-3,4-dihydro-2H-1,4-benzothiazine-6-carboxylate Basic information |
| Product Name: | Methyl 3-oxo-3,4-dihydro-2H-1,4-benzothiazine-6-carboxylate | | Synonyms: | Methyl 3,4-dihydro-3-oxo-2H-benzo[b][1,4]thiazine-6-carboxylate;Methyl 3-oxo-3,4-dihydro-2H-1,4-benzothiazine-6-carboxylate;Methyl-3-Oxo-3,4-Dihydro-2H-1,;Methyl 3,4-dihydro-3-oxo-2H-1,4-benzothiazine-6-carboxylate;methyl 3-oxo-3,4-dihydro-2H-benzo[b][1,4]thiazine-6-carboxylate;2-Methyl-3-oxo-3,4-dihydro-2H-1,4-benzothiazine-6-carboxylate;Methyl 3-Oxo-2H-1,4-benzothiazine-6-carboxylate;3-keto-4H-1,4-benzothiazine-6-carboxylic acid methyl ester | | CAS: | 188614-01-9 | | MF: | C10H9NO3S | | MW: | 223.25 | | EINECS: | | | Product Categories: | Fused Ring Systems;Heterocycle intermediates;Esters;API intermediates | | Mol File: | 188614-01-9.mol |  |
| | Methyl 3-oxo-3,4-dihydro-2H-1,4-benzothiazine-6-carboxylate Chemical Properties |
| Melting point | 180-182° | | Boiling point | 435.7±45.0 °C(Predicted) | | density | 1.343±0.06 g/cm3(Predicted) | | storage temp. | Sealed in dry,Room Temperature | | form | Solid | | pka | 12.34±0.20(Predicted) | | Appearance | White to off-white Solid | | CAS DataBase Reference | 188614-01-9(CAS DataBase Reference) |
| Hazard Codes | Xi | | HazardClass | IRRITANT | | HS Code | 2934999090 |
| | Methyl 3-oxo-3,4-dihydro-2H-1,4-benzothiazine-6-carboxylate Usage And Synthesis |
| Synthesis | GENERAL METHOD: A suspension of methyl 3-iodo-4-aminobenzoate (1 mmol), methyl thioglycolate (1.5 eq.), cuprous(I) iodide (0.05 mmol), trans-N,N'-dimethylcyclohexane-1,2-diamine (0.1 mmol), and cesium carbonate (2 eq.) in anhydrous 1,4-dioxane (4 mL) was added to a vial. Nitrogen was passed into the suspension to degas it for 3 min under stirring. Subsequently, the vial was sealed. The reaction mixture was heated at 100 °C (oil bath temperature) for 15 hours. After completion of the reaction, it was cooled to room temperature and filtered. The filtrates were combined and concentrated using a rotary evaporator and the resulting residue was purified by silica gel column chromatography (eluent: 5% dichloromethane solution in methanol) to afford the target product, methyl 3-carbonyl-3,4-dihydro-2H-1,4-benzothiazine-6-carboxylate, as a beige solid. | | References | [1] Tetrahedron Letters, 2013, vol. 54, # 38, p. 5214 - 5216 |
| | Methyl 3-oxo-3,4-dihydro-2H-1,4-benzothiazine-6-carboxylate Preparation Products And Raw materials |
|