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2,4-Dimethoxypyridine

2,4-Dimethoxypyridine Structure
2,4-Dimethoxypyridine structure
CAS No.
18677-43-5
Chemical Name:
2,4-Dimethoxypyridine
Synonyms
dihexyllead;2,4-Dimthoxypyridine;2,4-DIMETHOXYPYRIDINE;2,4-DimethoxypyridineI;Pyridine, 2,4-dimethoxy-;2,4-Dimethoxypyridine,>98%
CBNumber:
CB7105836
Molecular Formula:
C7H9NO2
Molecular Weight:
139.15
MDL Number:
MFCD01646187
MOL File:
18677-43-5.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-28 03:43:34
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2,4-Dimethoxypyridine Properties

Boiling point 200-201 °C
Density 1.064±0.06 g/cm3(Predicted)
storage temp. Inert atmosphere,Room Temperature
pka 4.71±0.10(Predicted)
Appearance Colorless to light yellow Liquid

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H332-H335
Precautionary statements  P261-P280-P305+P351+P338
HS Code  2933399990

2,4-Dimethoxypyridine price More Price(71)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Usbiological 274151 2,4-Dimethoxypyridine Asreported 18677-43-5 1g $376 2026-06-03 Buy
Usbiological 274151 2,4-Dimethoxypyridine Asreported 18677-43-5 2g $572 2026-06-03 Buy
Usbiological 274151 2,4-Dimethoxypyridine Asreported 18677-43-5 5g $802 2026-06-03 Buy
Usbiological 230917 2,4-Dimethoxypyridine 98+% (TLC) ≥98%(TLC) 18677-43-5 250mg $179 2026-06-03 Buy
Usbiological 230917 2,4-Dimethoxypyridine 98+% (TLC) ≥98%(TLC) 18677-43-5 1g $215 2026-06-03 Buy
Product number Packaging Price Buy
274151 1g $376 Buy
274151 2g $572 Buy
274151 5g $802 Buy
230917 250mg $179 Buy
230917 1g $215 Buy

2,4-Dimethoxypyridine Chemical Properties,Uses,Production

Uses

2,4-Dimethoxypyridine is mainly used as an organic synthesis intermediate for the synthesis of drug compounds such as PI3K inhibitors and has potential applications in anti-tumor therapy.

Synthesis

2,4-Dichloropyridine

26452-80-2

Sodium Methoxide

124-41-4

2,4-Dimethoxypyridine

18677-43-5

General procedure for the synthesis of 2,4-dimethoxypyridine from 2,4-dichloropyridine and sodium methanol: Freshly prepared sodium methanol (24 g, 0.44 mol) was added to an anhydrous N-methyl-2-pyrrolidinone (80 mL) solution of 2,4-dichloropyridine (15 g, 0.10 mol). The reaction mixture was stirred at 120 °C for 6 hours. After completion of the reaction, the mixture was cooled to room temperature, diluted with ethyl acetate (800 mL) and washed with water. The organic layer was separated, dried over anhydrous sodium sulfate, filtered and concentrated to give 2,4-dimethoxypyridine (4) as a colorless oil which was pure enough to be used in the next step. Yield: 11.2 g (80%).1H NMR (400 MHz, DMSO-d6): δ 3.80 (s, 3H), 3.84 (s, 3H), 6.33 (d, J = 2.0 Hz, 1H), 6.60 (dd, J = 2.0 Hz, J = 5.6 Hz, 1H), 7.97 (d, J = 5.6 Hz, 1H); 13C NMR (100 MHz, DMSO-d6): δ 167.5, 165.4, 147.4, 106.1, 93.8, 55.3, 53.1; HRMS (ESI) m/z calcd for C7H10NO2 [M+H]+: 140.0706; found: 140.0707.

References

[1] Xiaolin Li. “A Convenient Synthesis of Gimeracil.” Journal of Chemical Research-s 384 1 (2018): 33–34.
[2] Lucas Robke . “Discovery of 2,4-dimethoxypyridines as novel autophagy inhibitors.” Tetrahedron 74 35 (2018): Pages 4531-4537.

2,4-Dimethoxypyridine Preparation Products And Raw materials

Raw materials

2,4-Dichloropyridine 2-Chloro-4-methoxypyridine Sodium Methoxide

Preparation Products

3,5-Dibromo-2,4-dimethoxypyridine

2,4-Dimethoxypyridine Suppliers

Global( 93)Suppliers
Supplier Tel Email Country ProdList Advantage
Chembest Research Laboratories Limited 021-20908456 sales@BioChemBest.com China 5996 61
Alfa Aesar 400-6106006 saleschina@alfa-asia.com China 30103 84
Shijiazhuang Sdyano Fine Chemical Co., Ltd. 0311-89250318 13582355795 master@sjzsdyn.com China 2776 65
Shanghai Hanhong Scientific Co.,Ltd. 021-54306202 13764082696 info@hanhongsci.com China 42917 64
Chemsky（shanghai）International Co.,Ltd. 021-50135380 shchemsky@sina.com China 32273 50
Sichuan Kulinan Technology Co., Ltd 400-1166-196 18981987031 cdhxsj@163.com China 11674 57
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd. 025-66113011 13913916777 cfzhang@aikonchem.com China 19902 55
9ding chemical ( Shanghai) Limited 4009209199 sales@9dingchem.com China 18201 56
Wuhan Kaymke Chemical Co., Ltd., 027-87342388 18086026008 sales@kaymke.com China 3544 55
Cantotech Chemicals, Ltd. 86-0755-86635001 cantotech@126.com China 4554 55
Supplier Advantage
Chembest Research Laboratories Limited 61
Alfa Aesar 84
Shijiazhuang Sdyano Fine Chemical Co., Ltd. 65
Shanghai Hanhong Scientific Co.,Ltd. 64
Chemsky（shanghai）International Co.,Ltd. 50
Sichuan Kulinan Technology Co., Ltd 57
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd. 55
9ding chemical ( Shanghai) Limited 56
Wuhan Kaymke Chemical Co., Ltd., 55
Cantotech Chemicals, Ltd. 55

View Lastest Price from 2,4-Dimethoxypyridine manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2,4-DIMETHOXYPYRIDINE pictures 2020-02-14 2,4-DIMETHOXYPYRIDINE
18677-43-5
 $7.00 1KG 99% 100KG Career Henan Chemical Co

2,4-Dimethoxypyridine Spectrum

2,4-Dimethoxypyridine(18677-43-5)1HNMR

18677-43-5( 2,4-Dimethoxypyridine)Related Search:

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2,4-DIMETHOXYPYRIDINE dihexyllead 2,4-Dimethoxypyridine,>98% Pyridine, 2,4-dimethoxy- 2,4-DimethoxypyridineI 2,4-Dimthoxypyridine 18677-43-5 Pyridines