ChemicalBook >> CAS DataBase List >>2-Butenamide, N-[3-cyano-7-ethoxy-4-[[3-methyl-4-([1,2,4]triazolo[1,5-a]pyridin-7-yloxy)phenyl]amino]-6-quinolinyl]-4-(dimethylamino)-, (2E)-

2-Butenamide, N-[3-cyano-7-ethoxy-4-[[3-methyl-4-([1,2,4]triazolo[1,5-a]pyridin-7-yloxy)phenyl]amino]-6-quinolinyl]-4-(dimethylamino)-, (2E)-

2-Butenamide, N-[3-cyano-7-ethoxy-4-[[3-methyl-4-([1,2,4]triazolo[1,5-a]pyridin-7-yloxy)phenyl]amino]-6-quinolinyl]-4-(dimethylamino)-, (2E)- structure

CAS No.: 2401867-58-9

Chemical Name:: 2-Butenamide, N-[3-cyano-7-ethoxy-4-[[3-methyl-4-([1,2,4]triazolo[1,5-a]pyridin-7-yloxy)phenyl]amino]-6-quinolinyl]-4-(dimethylamino)-, (2E)-

Synonyms: JBJ-08-178-01;2-Butenamide, N-[3-cyano-7-ethoxy-4-[[3-methyl-4-([1,2,4]triazolo[1,5-a]pyridin-7-yloxy)phenyl]amino]-6-quinolinyl]-4-(dimethylamino)-, (2E)-

CBNumber:: CB710672791

Molecular Formula:: C31H30N8O3

Molecular Weight:: 562.62

MDL Number:

MOL File:: 2401867-58-9.mol

MSDS File:: SDS

Last updated:2025-04-18 09:52:35

Request For Quotation

2-Butenamide, N-[3-cyano-7-ethoxy-4-[[3-methyl-4-([1,2,4]triazolo[1,5-a]pyridin-7-yloxy)phenyl]amino]-6-quinolinyl]-4-(dimethylamino)-, (2E)- Properties

Density	1.28±0.1 g/cm3(Predicted)
pka	12.42±0.43(Predicted)

2-Butenamide, N-[3-cyano-7-ethoxy-4-[[3-methyl-4-([1,2,4]triazolo[1,5-a]pyridin-7-yloxy)phenyl]amino]-6-quinolinyl]-4-(dimethylamino)-, (2E)- Chemical Properties, Uses, Production

Uses

JBJ-08-178-01 is a mutant-selective tyrosine kinase inhibitor against human epidermal growth factor receptor 2 (HER2) with an antitumoral activity. JBJ-08-178-01 reduces both the kinase activity and protein levels of HER2 by inducing proteasomal degradation of the receptor in lung cancer. JBJ-08-178-01 is promising for research of non-small-cell lung cancer[1][2][3].

References

[1] Rubin E, et al. Molecular Targeting of the Human Epidermal Growth Factor Receptor-2 (HER2) Genes across Various Cancers. Int J Mol Sci. 2024 Jan 15;25(2):1064. DOI:10.3390/ijms25021064
[2] Vathiotis IA, et al. Evolving Treatment Landscape of HER2-mutant Non-Small Cell Lung Cancer: Trastuzumab Deruxtecan and Beyond. Cancers (Basel). 2023 Feb 17;15(4):1286. DOI:10.3390/cancers15041286
[3] Son J, et al. A Novel HER2-Selective Kinase Inhibitor Is Effective in HER2 Mutant and Amplified Non-Small Cell Lung Cancer. Cancer Res. 2022 Apr 15;82(8):1633-1645. DOI:10.1158/0008-5472.CAN-21-2693

2-Butenamide, N-[3-cyano-7-ethoxy-4-[[3-methyl-4-([1,2,4]triazolo[1,5-a]pyridin-7-yloxy)phenyl]amino]-6-quinolinyl]-4-(dimethylamino)-, (2E)- Preparation Products And Raw materials

Raw materials

Preparation Products

2-Butenamide, N-[3-cyano-7-ethoxy-4-[[3-methyl-4-([1,2,4]triazolo[1,5-a]pyridin-7-yloxy)phenyl]amino]-6-quinolinyl]-4-(dimethylamino)-, (2E)- Suppliers

Global Suppliers ( 1)

Supplier	Tel	Email	Country	ProdList	Advantage
TargetMol Chemicals Inc.	15002134094	marketing@targetmol.cn	China	29874	58

Supplier	Advantage
TargetMol Chemicals Inc.	58

2401867-58-9 (2-Butenamide, N-[3-cyano-7-ethoxy-4-[[3-methyl-4-([1,2,4]triazolo[1,5-a]pyridin-7-yloxy)phenyl]amino]-6-quinolinyl]-4-(dimethylamino)-, (2E)-) Related Search:

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2-Butenamide, N-[3-cyano-7-ethoxy-4-[[3-methyl-4-([1,2,4]triazolo[1,5-a]pyridin-7-yloxy)phenyl]amino]-6-quinolinyl]-4-(dimethylamino)-, (2E)- JBJ-08-178-01 2401867-58-9