2-Butenamide, N-[3-cyano-7-ethoxy-4-[[3-methyl-4-([1,2,4]triazolo[1,5-a]pyridin-7-yloxy)phenyl]amino]-6-quinolinyl]-4-(dimethylamino)-, (2E)-

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2-Butenamide, N-[3-cyano-7-ethoxy-4-[[3-methyl-4-([1,2,4]triazolo[1,5-a]pyridin-7-yloxy)phenyl]amino]-6-quinolinyl]-4-(dimethylamino)-, (2E)- Basic information
Product Name:2-Butenamide, N-[3-cyano-7-ethoxy-4-[[3-methyl-4-([1,2,4]triazolo[1,5-a]pyridin-7-yloxy)phenyl]amino]-6-quinolinyl]-4-(dimethylamino)-, (2E)-
Synonyms:2-Butenamide, N-[3-cyano-7-ethoxy-4-[[3-methyl-4-([1,2,4]triazolo[1,5-a]pyridin-7-yloxy)phenyl]amino]-6-quinolinyl]-4-(dimethylamino)-, (2E)-;JBJ-08-178-01
CAS:2401867-58-9
MF:C31H30N8O3
MW:562.62
EINECS:
Product Categories:
Mol File:2401867-58-9.mol
2-Butenamide, N-[3-cyano-7-ethoxy-4-[[3-methyl-4-([1,2,4]triazolo[1,5-a]pyridin-7-yloxy)phenyl]amino]-6-quinolinyl]-4-(dimethylamino)-, (2E)- Structure
2-Butenamide, N-[3-cyano-7-ethoxy-4-[[3-methyl-4-([1,2,4]triazolo[1,5-a]pyridin-7-yloxy)phenyl]amino]-6-quinolinyl]-4-(dimethylamino)-, (2E)- Chemical Properties
density 1.28±0.1 g/cm3(Predicted)
pka12.42±0.43(Predicted)
Safety Information
MSDS Information
2-Butenamide, N-[3-cyano-7-ethoxy-4-[[3-methyl-4-([1,2,4]triazolo[1,5-a]pyridin-7-yloxy)phenyl]amino]-6-quinolinyl]-4-(dimethylamino)-, (2E)- Usage And Synthesis
UsesJBJ-08-178-01 is a mutant-selective tyrosine kinase inhibitor against human epidermal growth factor receptor 2 (HER2) with an antitumoral activity. JBJ-08-178-01 reduces both the kinase activity and protein levels of HER2 by inducing proteasomal degradation of the receptor in lung cancer. JBJ-08-178-01 is promising for research of non-small-cell lung cancer[1][2][3].
References[1] Rubin E, et al. Molecular Targeting of the Human Epidermal Growth Factor Receptor-2 (HER2) Genes across Various Cancers. Int J Mol Sci. 2024 Jan 15;25(2):1064. DOI:10.3390/ijms25021064
[2] Vathiotis IA, et al. Evolving Treatment Landscape of HER2-mutant Non-Small Cell Lung Cancer: Trastuzumab Deruxtecan and Beyond. Cancers (Basel). 2023 Feb 17;15(4):1286. DOI:10.3390/cancers15041286
[3] Son J, et al. A Novel HER2-Selective Kinase Inhibitor Is Effective in HER2 Mutant and Amplified Non-Small Cell Lung Cancer. Cancer Res. 2022 Apr 15;82(8):1633-1645. DOI:10.1158/0008-5472.CAN-21-2693
2-Butenamide, N-[3-cyano-7-ethoxy-4-[[3-methyl-4-([1,2,4]triazolo[1,5-a]pyridin-7-yloxy)phenyl]amino]-6-quinolinyl]-4-(dimethylamino)-, (2E)- Preparation Products And Raw materials
Tag:2-Butenamide, N-[3-cyano-7-ethoxy-4-[[3-methyl-4-([1,2,4]triazolo[1,5-a]pyridin-7-yloxy)phenyl]amino]-6-quinolinyl]-4-(dimethylamino)-, (2E)-(2401867-58-9) Related Product Information
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