Spiraprilat
- CAS No.
- 83602-05-5
- Chemical Name:
- Spiraprilat
- Synonyms
- Spiraprilate;SCH 33861;TI-213-864;Spiraprilatum;Spiraprilatum [inn-latin];Spiraprilate [inn-french];(3S)-2-[(S)-2-[[(S)-1-Carboxy-3-phenylpropyl]amino]propionyl]-2-aza-6,9-dithiaspiro[4.4]nonane-3-carboxylic acid;(8S)-7-[(2S)-2-[[(1S)-1-Carboxy-3-phenylpropyl]amino]-1-oxopropyl]-1,4-dithia-7-azaspiro[4.4]nonane-8-carboxylic acid;1,4-Dithia-7-azaspiro(4.4)nonane-8-carboxylic acid, 7-(2-((1-carboxy-3-phenylpropyl)amino)-1-oxopropyl)-, (8S-(7(R*(R*)),8R*))-
- CBNumber:
- CB71116705
- Molecular Formula:
- C20H26N2O5S2
- Molecular Weight:
- 438.566
- MDL Number:
- MFCD00865779
- MOL File:
- 83602-05-5.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 163-165° |
|---|---|
| alpha | D26 +4.1° (c = 0.4 in ethanol) |
| FDA UNII | QS56V5Y7EC |
Spiraprilat Chemical Properties, Uses, Production
Uses
Spiraprilat is a potent angiotensin-converting enzyme (ACE) inhibitor. Spiraprilat has ability to improve left ventricular (LV) function and metabolism in anesthetized open-chest dogs with acute ventricular failure (ALVF)[1].
Definition
ChEBI: Spiraprilat is an azaspiro compound that is spirapril in which the ethyl ester group has been hydrolysed to the corresponding carboxylic acid group. It is the active metabolite of the angiotensin-converting enzyme (ACE) inhibitor spirapril. It has a role as an antihypertensive agent, an EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor and a drug metabolite. It is an azaspiro compound, a dicarboxylic acid, a dipeptide, a dithioketal, a pyrrolidinecarboxylic acid, a secondary amino compound and a tertiary carboxamide.
References
[1] Nakazawa M, et al. Effects of spiraprilat, an angiotensin-converting enzyme inhibitor, on anesthetized dogs in a new model of acute left ventricular failure. J Cardiovasc Pharmacol. 1993 Oct;22(4):585-93. DOI:10.1097/00005344-199310000-00012
Spiraprilat Preparation Products And Raw materials
Raw materials
Preparation Products
Spiraprilat Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 29874 | 58 |
| Supplier | Advantage |
|---|---|
| TargetMol Chemicals Inc. | 58 |
| TargetMol Chemicals Inc. | 58 |
