Spirapril
- CAS No.
- 83647-97-6
- Chemical Name:
- Spirapril
- Synonyms
- SPIRAPRIL;Sandopfil;Sch-33844;Espirapril;Brn 4277924;Spiraprilum;Spiraprilic acid;Spiraprilum [latin];Spirapril [inn:ban];Spirapril USP/EP/BP
- CBNumber:
- CB5285875
- Molecular Formula:
- C22H30N2O5S2
- Molecular Weight:
- 466.61
- MDL Number:
- MFCD00865789
- MOL File:
- 83647-97-6.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Boiling point | 697.8±55.0 °C(Predicted) |
|---|---|
| Density | 1.32±0.1 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| pka | 2.99±0.20(Predicted) |
| FDA UNII | 96U2K78I3V |
| ATC code | C09AA11 |
Spirapril price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Crysdot | CD31000684 | Spirapril 95+% | 83647-97-6 | 1g | $1191 | 2026-05-27 | Buy |
| AHH | MT-58707 | Spirapril 97% | 5g | $830 | 2026-05-26 | Buy | |
| American Custom Chemicals Corporation | API0004227 | SPIRAPRIL 95.00% | 83647-97-6 | 100MG | $624.57 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0004227 | SPIRAPRIL 95.00% | 83647-97-6 | 250MG | $697.34 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0004227 | SPIRAPRIL 95.00% | 83647-97-6 | 1G | $1904.7 | 2021-12-16 | Buy |
Spirapril Chemical Properties, Uses, Production
Chemical Properties
Hemihydrate: white foamy substance. [α]D26-29.5° (C=0.2, ethanol). Spirapril Hydrochloride (Spirapril Hydrochloride): C22 H3ON2O5S2HCl.[94841-17-5]. White solid, melting point 192-194°C (decomposition). [α]D26-11.2° (C=0.4, ethanol). Spiraprilat (Spiraprilat): C20H26N2O5S2.[83602-05-5]. Diacid for spirapril. Semihydrate, melting point 163～165°C. [α]D26+4.1° (C=0.4, ethanol).
Uses
Spirapril is an Angiotensin-converting enzyme inhibitor and used to treat high blood pressure.
Definition
ChEBI: Spirapril is a dipeptide, a dithioketal, an azaspiro compound, a dicarboxylic acid monoester, an ethyl ester, a tertiary carboxamide, a secondary amino compound and a pyrrolidinecarboxylic acid. It has a role as a prodrug, an EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor and an antihypertensive agent. It is functionally related to a spiraprilat.
in vivo
Spirapril (feeding needle; 10 mg/kg; 3 weeks) decreases alcohol intake in TGM123 mice and dose not reduce the alcohol consumption in TLM mice[2].
Spirapril shows a 40.2% reduction in ACE activity in brain membrane from treated-mice[2].
Spirapril can crosses the blood-brain barrier and suppresses the transgene effect in the experiments[2].
Spirapril prevents left ventricular hypertrophy, decreases myocardial damage and promotes angiogenesis in spontaneously hypertensive rats[3].
Spirapril Preparation Products And Raw materials
Raw materials
Preparation Products
Spirapril Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| LGM Pharma | 1-(800)-881-8210 | inquiries@lgmpharma.com | United States | 2110 | 70 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131885 | 58 |
| Aikon International Limited | 025-58859352 13913916777 | dt3@aikonchem.com | China | 15490 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-29-81139210 +86-17392587031 | 1059@dideu.com | China | 9983 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 +86-13203830695 | laboratory@coreychem.com | China | 30203 | 58 |
| SIMAGCHEM CORP | +86-5922680277 +86-13806087780 | sale@simagchem.com | China | 17339 | 58 |
| CONIER CHEM AND PHARMA LIMITED | sales@conier.com | China | 49906 | 58 | |
| Wuhan pengyin Pharmaceutical Co., Ltd | 13163333255 | 1939328613@qq.com | China | 392 | 58 |
| TargetMol Chemicals Inc. | 4008200310 15002144251 | marketing@tsbiochem.com | China | 24951 | 58 |
| Sinoway Industrial co., ltd. | +86-0592-5800732 +86-13806035118 | xie@china-sinoway.com | China | 1366 | 58 |
