Spirapril
- CAS No.
- 83647-97-6
- Chemical Name:
- Spirapril
- Synonyms
- SPIRAPRIL;Sandopfil;Sch-33844;Espirapril;Brn 4277924;Spiraprilum;Spiraprilic acid;Spiraprilum [latin];Spirapril [inn:ban];Spirapril USP/EP/BP
- CBNumber:
- CB5285875
- Molecular Formula:
- C22H30N2O5S2
- Molecular Weight:
- 466.61
- MDL Number:
- MFCD00865789
- MOL File:
- 83647-97-6.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| Spirapril 95+% | CD31000684 | 1g | $1191 |
| Spirapril 97% | MT-58707 | 5g | $830 |
| Spirapril 97% | MT-58707 | 5g | $830 |
| Spirapril 95+% | CD31000684 | 1g | $1191 |
| SPIRAPRIL 95.00% | API0004227 | 100MG | $624.57 |
| Boiling point | 697.8±55.0 °C(Predicted) |
|---|---|
| Density | 1.32±0.1 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| pka | 2.99±0.20(Predicted) |
| FDA UNII | 96U2K78I3V |
| ATC code | C09AA11 |
Spirapril price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Crysdot | CD31000684 | Spirapril 95+% | 83647-97-6 | 1g | $1191 | 2026-05-27 | Buy |
| AHH | MT-58707 | Spirapril 97% | 5g | $830 | 2026-05-26 | Buy | |
| AHH | MT-58707 | Spirapril 97% | 5g | $830 | 2026-05-25 | Buy | |
| Crysdot | CD31000684 | Spirapril 95+% | 83647-97-6 | 1g | $1191 | 2026-05-20 | Buy |
| American Custom Chemicals Corporation | API0004227 | SPIRAPRIL 95.00% | 83647-97-6 | 100MG | $624.57 | 2021-12-16 | Buy |
Spirapril Chemical Properties,Uses,Production
Chemical Properties
Hemihydrate: white foamy substance. [α]D26-29.5° (C=0.2, ethanol). Spirapril Hydrochloride (Spirapril Hydrochloride): C22 H3ON2O5S2HCl.[94841-17-5]. White solid, melting point 192-194°C (decomposition). [α]D26-11.2° (C=0.4, ethanol). Spiraprilat (Spiraprilat): C20H26N2O5S2.[83602-05-5]. Diacid for spirapril. Semihydrate, melting point 163～165°C. [α]D26+4.1° (C=0.4, ethanol).
Uses
Spirapril is an Angiotensin-converting enzyme inhibitor and used to treat high blood pressure.
Definition
ChEBI: Spirapril is a dipeptide, a dithioketal, an azaspiro compound, a dicarboxylic acid monoester, an ethyl ester, a tertiary carboxamide, a secondary amino compound and a pyrrolidinecarboxylic acid. It has a role as a prodrug, an EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor and an antihypertensive agent. It is functionally related to a spiraprilat.
in vivo
Spirapril (feeding needle; 10 mg/kg; 3 weeks) decreases alcohol intake in TGM123 mice and dose not reduce the alcohol consumption in TLM mice[2].
Spirapril shows a 40.2% reduction in ACE activity in brain membrane from treated-mice[2].
Spirapril can crosses the blood-brain barrier and suppresses the transgene effect in the experiments[2].
Spirapril prevents left ventricular hypertrophy, decreases myocardial damage and promotes angiogenesis in spontaneously hypertensive rats[3].
Spirapril Preparation Products And Raw materials
Raw materials
Preparation Products
Spirapril Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49979 | 58 |
| SIMAGCHEM CORP | +86-5922680277 +86-13806087780 | sale@simagchem.com | China | 17346 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | laboratory@coreychem.com | China | 30225 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-029-89586680 +86-18192503167 | 1026@dideu.com | China | 9996 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; | support@targetmol.com | United States | 39039 | 58 |
| TargetMol Chemicals Inc. | +17819995354 | marketing@targetmol.com | United States | 19956 | 58 |
| Sinoway Industrial co., ltd. | +86-0592-5800732 +86-13806035118 | xie@china-sinoway.com | China | 1369 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131957 | 58 |
| LGM Pharma | 1-(800)-881-8210 | inquiries@lgmpharma.com | United States | 2123 | 70 |
| Aikon International Limited | 025-58859352 19370895928 | dt3@aikonchem.com | China | 15491 | 58 |
