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ChemicalBook >> CAS DataBase List >>1H-Pyrazole-3-carboxamide, 4-[(2,6-difluorobenzoyl)amino]-N-[(tetrahydro-2H-pyran-4-yl)methyl]-

1H-Pyrazole-3-carboxamide, 4-[(2,6-difluorobenzoyl)amino]-N-[(tetrahydro-2H-pyran-4-yl)methyl]-

1H-Pyrazole-3-carboxamide, 4-[(2,6-difluorobenzoyl)amino]-N-[(tetrahydro-2H-pyran-4-yl)methyl]- Structure
1H-Pyrazole-3-carboxamide, 4-[(2,6-difluorobenzoyl)amino]-N-[(tetrahydro-2H-pyran-4-yl)methyl]- structure
CAS No.
844441-56-1
Chemical Name:
1H-Pyrazole-3-carboxamide, 4-[(2,6-difluorobenzoyl)amino]-N-[(tetrahydro-2H-pyran-4-yl)methyl]-
Synonyms
GSK3-IN-10;1H-Pyrazole-3-carboxamide, 4-[(2,6-difluorobenzoyl)amino]-N-[(tetrahydro-2H-pyran-4-yl)methyl]-
CBNumber:
CB711894875
Molecular Formula:
C17H18F2N4O3
Molecular Weight:
364.35
MDL Number:
MOL File:
844441-56-1.mol
Last updated:2026-01-13 11:25:41
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1H-Pyrazole-3-carboxamide, 4-[(2,6-difluorobenzoyl)amino]-N-[(tetrahydro-2H-pyran-4-yl)methyl]- Properties

Boiling point 539.9±50.0 °C(Predicted)
Density 1.389±0.06 g/cm3(Predicted)
solubility DMSO: 2 mg/mL, clear
pka 10.80±0.70(Predicted)
form powder
color white to beige
SMILES O=C(NCC1CCOCC1)C2=NNC=C2NC(C3=C(C=CC=C3F)F)=O
NACRES NA.28

1H-Pyrazole-3-carboxamide, 4-[(2,6-difluorobenzoyl)amino]-N-[(tetrahydro-2H-pyran-4-yl)methyl]- Chemical Properties,Uses,Production

Uses

GSK3-IN-10 (Compound 4) is a multi-target inhibitor, that mainly targets GSK3α and GSK3β with IC50 of 1.0 nM and 2.0 nM. GSK3-IN-10 inhibits the activation of β-catenin, promotes the neuronal survival, and exhibits a protective effect against endoplasmic reticulum stress[1].

IC 50

GSK-3α: 1.0 nM (IC50); GSK-3β: 2.0 nM (IC50); DYRK1B: 47 nM (IC50); DYRK1A: 170 nM (IC50); ICK: 520 nM (IC50); CLK1: 620 nM (IC50); CLK4: 760 nM (IC50); DYRK2: 800 nM (IC50); CLK2: 800 nM (IC50); CDKL5: 840 nM (IC50); JNK3: 2900 nM (IC50); CDK4: 3800 nM (IC50)

References

[1] Ong HW, et al., Discovery of a Potent and Selective CDKL5/GSK3 Chemical Probe That Is Neuroprotective. ACS Chem Neurosci. 2023 May 3;14(9):1672-1685. DOI:10.1021/acschemneuro.3c00135

1H-Pyrazole-3-carboxamide, 4-[(2,6-difluorobenzoyl)amino]-N-[(tetrahydro-2H-pyran-4-yl)methyl]- Preparation Products And Raw materials

Raw materials

Preparation Products

1H-Pyrazole-3-carboxamide, 4-[(2,6-difluorobenzoyl)amino]-N-[(tetrahydro-2H-pyran-4-yl)methyl]- Suppliers

Global( 2)Suppliers
Supplier Tel Email Country ProdList Advantage
Shanghai Beckham Medical Technology Co., Ltd 13816613772 huahero21@sina.com China 2996 55
TargetMol 400-821-0310 15002144251 xuexiang.shao@tsbiochem.com China 29128 58
Supplier Advantage
Shanghai Beckham Medical Technology Co., Ltd 55
TargetMol 58

844441-56-1(1H-Pyrazole-3-carboxamide, 4-[(2,6-difluorobenzoyl)amino]-N-[(tetrahydro-2H-pyran-4-yl)methyl]-)Related Search:

THZ1 GSK-3326595 DRB INX-315 CDK2 Protein, HUMAN (HIS)
PCTAIRE1 Protein, Human (sf9, GST)

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1H-Pyrazole-3-carboxamide, 4-[(2,6-difluorobenzoyl)amino]-N-[(tetrahydro-2H-pyran-4-yl)methyl]- GSK3-IN-10 844441-56-1