Naltrexone hydrochloride
- CAS No.
- 16676-29-2
- Chemical Name:
- Naltrexone hydrochloride
- Synonyms
- ReVia;Depade;nih8503;en1639a;Nalorex;Antaxone;4-D-butyl;Ccris 1168;NSC 409767;Nalmefene-3
- CBNumber:
- CB7121465
- Molecular Formula:
- C20H24ClNO4
- Molecular Weight:
- 377.87
- MDL Number:
- MFCD00069324
- MOL File:
- 16676-29-2.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 274-2760C |
|---|---|
| storage temp. | 2-8°C |
| solubility | H2O: 50 mg/mL, clear, colorless |
| form | powder |
| color | White to Off-White |
| Water Solubility | Soluble in water at 50mg/ml. |
| Sensitive | Light Sensitive |
| Merck | 13,6389 |
| BRN | 3580333 |
| InChIKey | RHBRMCOKKKZVRY-LNTCFJBQNA-N |
| SMILES | O[C@]12CCC(=O)[C@]3([H])OC4=C(C=CC5C[C@@]1([H])N(CC1CC1)CC[C@@]23C4=5)O.Cl |&1:1,6,15,24,r| |
| CAS DataBase Reference | 16676-29-2(CAS DataBase Reference) |
| EWG's Food Scores | 1 |
| NCI Dictionary of Cancer Terms | naltrexone hydrochloride; ReVia |
| FDA UNII | Z6375YW9SF |
| NCI Drug Dictionary | Depade |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302 | |||||||||
| Precautionary statements | P301+P312+P330 | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 22 | |||||||||
| Safety Statements | 22-36 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | QD2160000 | |||||||||
| F | 8-10 | |||||||||
| HS Code | 2932.99.7000 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Acute Tox. 4 Oral | |||||||||
| Toxicity | guinea pig,LD50,oral,1490mg/kg (1490mg/kg),Medicamentos de Actualidad. Vol. 21, Pg. 264, 1985. | |||||||||
| NFPA 704 |
|
Naltrexone hydrochloride price More Price(33)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | N3136 | Naltrexone hydrochloride | 16676-29-2 | 100mg | $116 | 2026-04-30 | Buy |
| Sigma-Aldrich | Y0000400 | Naltrexone hydrochloride European Pharmacopoeia (EP) Reference Standard | 16676-29-2 | 50 mg | $254 | 2026-04-30 | Buy |
| Sigma-Aldrich | N3136 | Naltrexone hydrochloride | 16676-29-2 | 1g | $698 | 2026-04-30 | Buy |
| TCI Chemical | N1176 | Naltrexone Hydrochloride | 16676-29-2 | 250MG | $164 | 2026-04-30 | Buy |
| TCI Chemical | N1176 | Naltrexone Hydrochloride | 16676-29-2 | 1G | $489 | 2026-04-30 | Buy |
Naltrexone hydrochloride Chemical Properties, Uses, Production
Description
Naltrexone hydrochloride is a potent, long-acting, orally-effective narcotic antagonist useful in the management of narcotic addiction.
Chemical Properties
White Crystalline Powder
Originator
Endo (USA)
Uses
Nonselective opioid receptor antagonist; congener of naloxone
Uses
Naltrexone hydrochloride has been used:
as an opioid antagonist, to analyse its effect on ethanol preference using Caenorhabditis elegans as a model.
to determine its effectiveness in reducing the preference for substance of abuse (SOA) like nicotine and cocaine using Caenorhabditis elegans as a model.
in the preparation of combinatorial drug, PXT3003 for treating Charcot-Marie-Tooth disease 1A (CMT1A) transgenic rat model Pmp22.
Uses
sulfonamide, carbonic anhydrase inhibitor, anti-glaucoma agent
Uses
Narcotic antagonist, In treatment ofalcoholism
Definition
ChEBI: Naltrexone hydrochloride is a hydrochloride obtained by reaction of oxycodone with one molar equivalent of hydrochloric acid. it is a mu-opioid receptor antagonist that is used to treat alcohol dependence. It has a role as a mu-opioid receptor antagonist, an antidote to opioid poisoning and a central nervous system depressant. It contains a naltrexone(1+).
brand name
TREXAN
Biological Activity
Opioid antagonist.
Biochem/physiol Actions
Competitive antagonist for μ, κ, δ, and σ-opioid receptors; has greater oral efficacy and longer duration of action than naloxone.
Clinical Use
Opioid antagonist:
Adjunctive prophylactic treatment in patient’s
previously opioid dependant
Treatment of alcohol dependence
Drug interactions
Potentially hazardous interactions with other drugs
Opioids: Avoid concomitant use.
Metabolism
Naltrexone is well absorbed from the gastrointestinal tract but is subject to considerable first-pass metabolism and may undergo enterohepatic recycling. It is extensively metabolised in the liver and the major metabolite, 6-β-naltrexol, may also possess weak opioid antagonist activity. It is excreted mainly in the urine, <5% is excreted in the faeces. The renal clearance for naltrexone ranges from 30-127 mL/min and suggests that renal elimination is primarily by glomerular filtration
storage
Room temperature
Purification Methods
This narcotic antagonist has been purified by recrystallisation from MeOH and dried in air. The free base has m 168-170o after recrystallisation from Me2CO. [Cone et al. J Pharm Sci 64 618 1975, Gold et al. Med Res Rev 2 211 1982.]
Naltrexone hydrochloride Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| SHAOXING ZHIJUN PHARMACEUTICAL TECHNOLOGY CO.,LTD | 0575-82126188 13858337171 | service@zejunpharma.com | China | 75 | 58 |
| Originchem Co., Ltd | 0523-0523-86200346 15996028822 | 1583458435@qq.com | China | 79 | 58 |
| Chengdu Chuxin Pharmaceutical Technology Co., Ltd | 18782972721 | summer@earlyfaith.cn | China | 7 | 58 |
| Shanghai Qiao Chemical Science Co., Ltd | 021-58892003 | info@qiaochem.com | China | 6065 | 65 |
| Jinan Xinwei Pharmaceutical Technology Co., LTD | 18354101831 13356699551 | 2067831699@qq.com | China | 101 | 58 |
| Cangzhou Enke Pharma-tech Co., Ltd. | 0317-5296180 15533709196 | enkepharma@126.com | China | 2495 | 55 |
| YICHANG TIANRUI BIOPHARM CO., LTD | 13469840438 | caiweiguo@renfu.com.cn | China | 48 | 58 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 18930552037 | 3bsc@sina.com | China | 15813 | 69 |
| ZHIWE CHEMTECH CO LTD | 021-20221225 13917446399 | zwchem@163.com | China | 525 | 61 |
| ShangHai DEMO Chemical Co.,Ltd | 400-021-7337 2355568890 | sales@demochem.com | China | 2569 | 57 |
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View Latest Price from Naltrexone hydrochloride manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-16 | Naltrexone hydrochloride
16676-29-2
|
0.99 | RongNa Biotechnology Co.,Ltd | ||||
 |
2026-08-25 | Naltrexone hydrochloride
16676-29-2
|
1KG | 0.99 | 1000KG | Shaanxi Xianhe Biotech Co., Ltd | ||
 |
2025-06-25 | Naltrexone hydrochloride
16676-29-2
|
$1.10 | 1g | 99.0% min | 100 tons min | Shaanxi Dideu Medichem Co. Ltd |
-
- Naltrexone hydrochloride
16676-29-2
- 0.99
- RongNa Biotechnology Co.,Ltd
-
- Naltrexone hydrochloride
16676-29-2
- $0.00
- 0.99
- Shaanxi Xianhe Biotech Co., Ltd
-
- Naltrexone hydrochloride
16676-29-2
- $1.10
- 99.0% min
- Shaanxi Dideu Medichem Co. Ltd
