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NORBUPRENORPHINE

NORBUPRENORPHINE Structure
NORBUPRENORPHINE structure
CAS No.
78715-23-8
Chemical Name:
NORBUPRENORPHINE
Synonyms
N-Dealkylbuprenorphine;OSD S L1;OSD S L2;OSD U L4;OSD U L1;OSD U L3;OSD S L4;OSD U L2;OSD S L3;OSD VB L3
CBNumber:
CB7121849
Molecular Formula:
C25H35NO4
Molecular Weight:
413.55
MDL Number:
MFCD00190626
MOL File:
78715-23-8.mol
MSDS File:
SDS
Last updated:2026-05-28 02:36:36
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NORBUPRENORPHINE Properties

Melting point 221-224°C
Boiling point 562.7±50.0 °C(Predicted)
Density 1.27±0.1 g/cm3(Predicted)
Flash point 9℃
storage temp. -20°C Freezer, Under Inert Atmosphere
solubility Chloroform (Sparingly), Methanol (Slightly)
pka 9.14±0.60(Predicted)
form A neat solid
InChIKey YOYLLRBMGQRFTN-IOMBULRVSA-N
SMILES CO[C@]12CC[C@@]3(C[C@@H]1[C@](C)(O)C(C)(C)C)[C@H]4Cc5ccc(O)c6O[C@@H]2[C@]3(CCN4)c56
FDA UNII 7E53B4O073
UNSPSC Code 41116107
NACRES NA.24

SAFETY

Risk and Safety Statements

Symbol(GHS)  Flame (GHS02)Skull and Crossbones (GHS06)Health Hazard (GHS08)
GHS02,GHS06,GHS08
Signal word  Danger
Hazard statements  H225-H301+H311+H331-H370
Precautionary statements  P210-P260-P280-P301+P310-P311
target organs Eyes,Central nervous system
Hazard Codes  F,T
Risk Statements  11-23/24/25-39/23/24/25
Safety Statements  16-36/37-45-7
RIDADR  UN1230 - class 3 - PG 2 - Methanol, solution
WGK Germany  1
Storage Class 3 - Flammable liquids
Hazard Classifications Acute Tox. 3 Dermal
Acute Tox. 3 Inhalation
Acute Tox. 3 Oral
Flam. Liq. 2
STOT SE 1
REACH Registrations Inactive
NFPA 704
0
3 0

NORBUPRENORPHINE price More Price(13)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich N-912 Norbuprenorphine solution 100?μg/mL in methanol, ampule of 1?mL, certified reference material, Cerilliant? 78715-23-8 1mL $40.7 2026-04-30 Buy
Sigma-Aldrich N-059S Norbuprenorphine solution 1 mg/mL in methanol, certified reference material, ampule of 1 mL, Cerilliant® 78715-23-8 1 mL $442 2026-04-30 Buy
Sigma-Aldrich N-059 Norbuprenorphine solution 1.0?mg/mL in methanol, ampule of 1?mL, certified reference material, Cerilliant? 78715-23-8 1mL $448 2026-04-30 Buy
Sigma-Aldrich N-059S Norbuprenorphine solution 1 mg/mL in methanol, certified reference material, ampule of 1 mL, Cerilliant® 78715-23-8 1 unit $421 2025-07-31 Buy
Cayman Chemical 42206 Norbuprenorphine (CRM) 78715-23-8 100μg $41 2026-04-30 Buy
Product number Packaging Price Buy
N-912 1mL $40.7 Buy
N-059S 1 mL $442 Buy
N-059 1mL $448 Buy
N-059S 1 unit $421 Buy
42206 100μg $41 Buy

NORBUPRENORPHINE Chemical Properties,Uses,Production

Description

Norbuprenorphine (CRM) (Item No. 20127) is a certified reference material categorized as an opioid. It is a major active metabolite of buprenorphine (Item Nos. 14025 | ISO60178). This product is intended for research and forensic applications.

Chemical Properties

Light Brown Solid

Uses

A metabolite of Buprenorphine

Definition

ChEBI: Norbuprenorphine is a member of phenanthrenes.

References

[1] De Souza, F.I., Zumiotti, A.V., and Da Silva, C.F. Neuregulins 1-α and 1-β on the regeneration the peripheral nerves[J]. Acta Ortop Bras.
[2] E J CONE. The metabolism and excretion of buprenorphine in humans.[J]. Drug Metabolism and Disposition, 1984, 12 5: 577-581.

NORBUPRENORPHINE Preparation Products And Raw materials

Raw materials

Preparation Products

78715-23-8(NORBUPRENORPHINE)Related Search:

4,8-Dimethyl-1-phenylnonane (1R,2S)-(-)-trans-2-Phenyl-1-cyclohexanol BUPRENORPHINE 2,4-DIMETHYL-4-PHENYLPENTAN-2-OL p-isooctylphenol
NORBUPRENORPHINE TRANS-2-PHENYL-1-CYCLOHEXANOL octamylamine 4,4-DIPROPYLHEPTANE 4-tert-Butylcyclohexanol
CHEMBRDG-BB 4005901 4-N-PROPYLBICYCLO[2.2.2]OCTAN-1-OL CHEMBRDG-BB 4005902 (-)-NEOMENTHOL 4-METHYL-1-PHENYL-2-PENTANOL
2-(1-methylnonyl)phenol

1of4

(aS,5a,7a)-a-(1,1-Dimethylethyl)-4,5-epoxy-18,19-dihydro-3-hydroxy-6-methoxy-a-methyl-6,14-ethenomorphinan-7-methanol N-De(cyclopropylmethyl)buprenorphine N-Desalkylbuprenorphin 6,14-Ethenomorphinan-7-methanol, .alpha.-(1,1-dimethylethyl)-4,5-epoxy-18,19-dihydro-3-hydroxy-6-methoxy-.alpha.-methyl-, (.alpha.S,5.alpha.,7.alpha.)- N-Desalkylbuprenorphine (αS)-α-tert-Butyl-4,5α-epoxy-3-hydroxy-6-methoxy-α-methyl-6β,14-ethanomorphinan-7α-methanol N-Des(cyclopropylmethyl)buprenorphine NORBUPRENORPHINE (αS,5α,7α)-α-(1,1-DiMethylethyl)-4,5-epoxy-18,19-dihydro-3-hydroxy-6-Methoxy-α-Methyl-6,14-ethenoMorphinan-7-Methanol Norbuprenorphine (1.0 Mg/ML in Methanol) Norbuprenorphine solution Norbuprenorphine (CRM) 6,14-Ethenomorphinan-7-methanol, α-(1,1-dimethylethyl)-4,5-epoxy-18,19-dihydro-3-hydroxy-6-methoxy-α-methyl-, (αS,5α,7α)- Buprenorphine Hydrochloride Impurity B Buprenorphine Impurity B Buprenorphine Hydrochloride EP Impurity B (2S)-2-(4,5α-epoxy-3-hydroxy-6-methoxy-6α,14-ethano-14α-morphinan-7α-yl)-3,3-dimethylbutan-2-ol (norbuprenorphine), (2S)-(5α,7α)-7-(2-hydroxy-3,3-dimethylbutan-2-yl)-6-methoxy-18,19-dihydro-4,5-epoxy-6,14-ethenomorphinan-3-ol (2S)-2-(4,5alpha-Epoxy-3-hydroxy-6-methoxy-6alpha,14-ethano-14alpha-morphinan-7alpha-yl)-3,3-dimethy Toremifene Impurity 19 Controlled Substance(Buprenorphine EP Impurity B) Norbuprenorphine, 1mg/ml in Methanol Norbuprenorphine 0.1 mg/ml in Methanol (2S)-2-(4,5alpha-Epoxy-3-hydroxy-6-methoxy-6alpha,14-ethano-14alpha-morphinan-7alpha-yl)-3,3-dimethylbutan-2-ol (Norbuprenorphine) Opioid Substitution Drugs in Serum OSD S, level 2 Opioid substitution drugs in whole blood OSD L2 OSD S L1 Opioid Substitution Drugs in Urine OSD U L3 OSD S L2 STM 1/13-A SE OSD VB L3 OSD U L4 OSD U L1 OSD U L3 Opioid Substitution Drugs in Urine OSD U L4 Opioid Substitution Drugs in Urine OSD U L2 Opioid substitution drugs in whole blood Level 1 Opioid Substitution Drugs in Serum OSD S, level 0-4 OSD S L4 OSD VB L2 Opioid substitution drugs in whole blood Level 3 Opioid substitution drugs in whole blood OSD L0-L3 Opioid Substitution Drugs in Serum OSD S, level 3 Opioid Substitution Drugs in Serum OSD S, level 4 OSD U L2 OSD VB L1 Opioid Substitution Drugs in Serum OSD S, level 1 OSD S L3 Buprenorphine EP Impurity B (Norbuprenorphine) N-Dealkylbuprenorphine 78715-23-8 C25H35NO4 Amines Chiral Reagents Heterocycles Intermediates & Fine Chemicals Metabolites & Impurities Pharmaceuticals