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| | NORBUPRENORPHINE Basic information |
| Product Name: | NORBUPRENORPHINE | | Synonyms: | (aS,5a,7a)-a-(1,1-Dimethylethyl)-4,5-epoxy-18,19-dihydro-3-hydroxy-6-methoxy-a-methyl-6,14-ethenomorphinan-7-methanol;N-De(cyclopropylmethyl)buprenorphine;N-Desalkylbuprenorphin;6,14-Ethenomorphinan-7-methanol, .alpha.-(1,1-dimethylethyl)-4,5-epoxy-18,19-dihydro-3-hydroxy-6-methoxy-.alpha.-methyl-, (.alpha.S,5.alpha.,7.alpha.)-;N-Desalkylbuprenorphine;(αS)-α-tert-Butyl-4,5α-epoxy-3-hydroxy-6-methoxy-α-methyl-6β,14-ethanomorphinan-7α-methanol;N-Des(cyclopropylmethyl)buprenorphine;NORBUPRENORPHINE | | CAS: | 78715-23-8 | | MF: | C25H35NO4 | | MW: | 413.55 | | EINECS: | 200-659-6 | | Product Categories: | Amines;Chiral Reagents;Heterocycles;Intermediates & Fine Chemicals;Metabolites & Impurities;Pharmaceuticals | | Mol File: | 78715-23-8.mol |  |
| | NORBUPRENORPHINE Chemical Properties |
| Melting point | 221-224°C | | Boiling point | 562.7±50.0 °C(Predicted) | | density | 1.27±0.1 g/cm3(Predicted) | | Fp | 9℃ | | storage temp. | -20°C Freezer, Under Inert Atmosphere | | solubility | Chloroform (Sparingly), Methanol (Slightly) | | pka | 9.14±0.60(Predicted) | | form | A neat solid | | InChIKey | YOYLLRBMGQRFTN-IOMBULRVSA-N | | SMILES | CO[C@]12CC[C@@]3(C[C@@H]1[C@](C)(O)C(C)(C)C)[C@H]4Cc5ccc(O)c6O[C@@H]2[C@]3(CCN4)c56 |
| Hazard Codes | F,T | | Risk Statements | 11-23/24/25-39/23/24/25 | | Safety Statements | 16-36/37-45-7 | | RIDADR | UN1230 - class 3 - PG 2 - Methanol, solution | | WGK Germany | 1 | | Storage Class | 3 - Flammable liquids | | Hazard Classifications | Acute Tox. 3 Dermal
Acute Tox. 3 Inhalation
Acute Tox. 3 Oral
Flam. Liq. 2
STOT SE 1 |
| | NORBUPRENORPHINE Usage And Synthesis |
| Description | Norbuprenorphine (CRM) (Item No. 20127) is a certified reference material categorized as an opioid. It is a major active metabolite of buprenorphine (Item Nos. 14025 | ISO60178). This product is intended for research and forensic applications. | | Chemical Properties | Light Brown Solid | | Uses | A metabolite of Buprenorphine | | Definition | ChEBI: Norbuprenorphine is a member of phenanthrenes. | | References | [1] De Souza, F.I., Zumiotti, A.V., and Da Silva, C.F. Neuregulins 1-α and 1-β on the regeneration the peripheral nerves[J]. Acta Ortop Bras.
[2] E J CONE. The metabolism and excretion of buprenorphine in humans.[J]. Drug Metabolism and Disposition, 1984, 12 5: 577-581.
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| | NORBUPRENORPHINE Preparation Products And Raw materials |
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