2-Bromo-3-methoxybenzoic acid
- CAS No.
- 88377-29-1
- Chemical Name:
- 2-Bromo-3-methoxybenzoic acid
- Synonyms
- 2-Bromo-3-methoxybenzoic acid;Benzoic acid, 2-bromo-3-methoxy-
- CBNumber:
- CB71240998
- Molecular Formula:
- C8H7BrO3
- Molecular Weight:
- 231.04
- MDL Number:
- MFCD11848447
- MOL File:
- 88377-29-1.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P271-P260-P280 |
| HS Code | 2916310090 |
2-Bromo-3-methoxybenzoic acid price More Price(49)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | TRC-B700505-50MG | 2-Bromo-3-methoxybenzoic Acid | 88377-29-1 | 50mg | $64 | 2026-06-03 | Buy |
| TRC | TRC-B700505-500MG | 2-Bromo-3-methoxybenzoic Acid | 88377-29-1 | 500mg | $167 | 2026-06-03 | Buy |
| TRC | TRC-B700505-100MG | 2-Bromo-3-methoxybenzoic Acid | 88377-29-1 | 100mg | $78 | 2026-06-03 | Buy |
| Biosynth | NDA37729 | 2-Bromo-3-methoxybenzoic acid | 88377-29-1 | 10g | $354 | 2026-06-04 | Buy |
| Activate Scientific | AS39435 | 2-Bromo-3-methoxybenzoic acid 98% | 88377-29-1 | 1g | $30 | 2026-06-04 | Buy |
2-Bromo-3-methoxybenzoic acid Chemical Properties, Uses, Production
Synthesis
3177-80-8
88377-29-1
General procedure for the synthesis of 2-bromo-3-methoxybenzoic acid from 2-amino-3-methoxybenzoic acid: 2-amino-3-methoxybenzoic acid (4.00 g, 23.9 mmol) was dissolved in 10% aqueous hydrobromic acid (54 ml) at 0 °C. Subsequently, an aqueous solution of sodium nitrite (1.65 g, 23.9 mmol) (17 ml) was slowly added. A 48% hydrobromic acid solution (22 ml) of copper (I) bromide (3.78 g, 26.3 mmol) was added dropwise to the reaction system under stirring. The reaction mixture was gradually warmed up to 60°C and maintained at this temperature for 2 hours. After completion of the reaction, the mixture was cooled to 0°C and the resulting precipitate was collected by filtration. The precipitate was washed with cold water and purified by recrystallization in water to finally obtain pure 2-bromo-3-methoxybenzoic acid (4.07 g, 74% yield). The product was analyzed by mass spectrometry (EI) and the molecular ion peak (MH+) of C8H7BrO3 was 232.
References
[1] Tetrahedron, 2001, vol. 57, # 23, p. 4967 - 4975
[2] Angewandte Chemie - International Edition, 2010, vol. 49, # 40, p. 7257 - 7260
[3] Patent: WO2009/55077, 2009, A1. Location in patent: Page/Page column 388-389
[4] Journal of Medicinal Chemistry, 1984, vol. 27, # 3, p. 363 - 367
[5] Bioorganic and Medicinal Chemistry Letters, 2014, vol. 24, # 14, p. 3018 - 3022
2-Bromo-3-methoxybenzoic acid Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Shanghai Sinch Parmaceuticals Tech. Co. Ltd. | +86-21-54098501 | sales@sinch.com.cn | China | 11592 | 64 |
| Tetranov Biopharm | 13526569071 | sales@leadmedpharm.com | China | 7881 | 64 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| Shanghai Jian Chao Chemical Technology Co., Ltd. | 150-2103-5486 18017383231 | 983544897@qq.com | China | 9335 | 55 |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
| Shanghai Taifu Pharmaceutical Technology Co. LTD | 021-58111238 18930958102 | sales@taifupharm.com | China | 509 | 55 |
| Xinyanhe Pharmatech Co.,Ltd | 0519-85252752 15366845260 | taihuaren@vip.163.com | China | 1032 | 58 |
| Mashilabs (Shanghai) Co.,Ltd. | 19916721580 | mafarm@126.com | China | 4534 | 58 |
| Hangzhou J&H Chemical Co., Ltd. | 0571-87396432 | sales@jhechem.com | China | 14905 | 59 |
