2-Amino-3-methoxybenzoic acid
- CAS No.
- 3177-80-8
- Chemical Name:
- 2-Amino-3-methoxybenzoic acid
- Synonyms
- 3-METHOXYANTHRANILIC ACID;2-AMINO-M-ANISIC ACID;3-methoxyantharanilic acid;O-ANISIDINE-6-CARBOXYLIC ACID;2-Amino-3-methoxybenzoic acid;2-azanyl-3-methoxy-benzoic acid;Fluoroestradiol Impurity 12-18F;Benzoic acid, 2-amino-3-methoxy-;2-AMino-3-(Methyloxy)benzoic acid;2-AMino-3-Methoxybenzoic acid 98%
- CBNumber:
- CB7697887
- Molecular Formula:
- C8H9NO3
- Molecular Weight:
- 167.16
- MDL Number:
- MFCD00075178
- MOL File:
- 3177-80-8.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 169-170 °C (lit.) |
|---|---|
| Boiling point | 333.9±27.0 °C(Predicted) |
| Density | 1.303±0.06 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| pka | 4.82±0.10(Predicted) |
| form | Powder |
| color | White to yellow to brown |
| Major Application | peptide synthesis |
| InChI | InChI=1S/C8H9NO3/c1-12-6-4-2-3-5(7(6)9)8(10)11/h2-4H,9H2,1H3,(H,10,11) |
| InChIKey | SXOPCLUOUFQBJV-UHFFFAOYSA-N |
| SMILES | C(O)(=O)C1=CC=CC(OC)=C1N |
| CAS DataBase Reference | 3177-80-8(CAS DataBase Reference) |
| FDA UNII | HU74W6CCX9 |
| UNSPSC Code | 12352200 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P305+P351+P338-P280a-P304+P340-P405-P501a-P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313 | |||||||||
| target organs | Respiratory system | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-37/39 | |||||||||
| WGK Germany | 3 | |||||||||
| HS Code | 29225090 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
|||||||||
| NFPA 704 |
|
2-Amino-3-methoxybenzoic acid price More Price(93)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 340103 | 2-Amino-3-methoxybenzoic acid 98% | 3177-80-8 | 1g | $44.9 | 2023-01-07 | Buy |
| Sigma-Aldrich | 340103 | 2-Amino-3-methoxybenzoic acid 98% | 3177-80-8 | 5g | $195 | 2023-01-07 | Buy |
| TCI Chemical | A1378 | 2-Amino-3-methoxybenzoic Acid >99.0%(HPLC)(T) | 3177-80-8 | 5g | $74 | 2026-04-30 | Buy |
| TCI Chemical | A1378 | 2-Amino-3-methoxybenzoic Acid >99.0%(HPLC)(T) | 3177-80-8 | 25g | $253 | 2026-04-30 | Buy |
| TRC | TRC-A612010-1G | 2-Amino-3-methoxybenzoic Acid | 3177-80-8 | 1g | $59 | 2026-06-03 | Buy |
2-Amino-3-methoxybenzoic acid Chemical Properties,Uses,Production
Synthesis
The preparation of the target compound 2,3-diamino-5-bromopyridine from 2-amino-3-nitro-5-bromopyridine is a typical reduction reaction, involving the reduction of the nitro group to obtain the target product. However, due to the low efficiency of the reduction reaction, the large amount of reduction waste, and the complex post-processing, it is not an ideal preparation route. Nevertheless, the readily available starting materials and the one-step reaction preparation of the target compound have their advantages. This paper optimizes the reaction conditions by investigating the reduction process, employing Raney Ni catalytic hydrogenation during the reduction process, resulting in high product purity. The synthetic reaction formula is shown in the figure below:
Chemical Properties
White to light brown crystals or powder
Uses
2-Amino-3-methoxybenzoic Acid is used in the preparation of CDK1/cyclin B inhibitors for application towards antitumor treatment. In addition, it is used in the synthesis of Alogliptin, an inhibitor o f dipeptidy peptidase, which aids in the lowering of blood-glucose for potential treatment of diabetes.
Definition
ChEBI: 3-methoxyanthranilic acid is an aminobenzoic acid that is anthranilic acid in which the hydrogen at position 3 is substituted by a methoxy group. It is a metabolite of kynurenine. It has a role as a mammalian metabolite. It is a member of benzoic acids and an aminobenzoic acid. It is functionally related to an anthranilic acid. It is a conjugate acid of a 3-methoxyanthranilate.
Synthesis Reference(s)
The Journal of Organic Chemistry, 63, p. 6797, 1998 DOI: 10.1021/jo972158g
reaction suitability
reaction type: solution phase peptide synthesis
2-Amino-3-methoxybenzoic acid Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Carbott PharmTech Inc. | 0535-6385396 | info@carbottpharm.com | China | 996 | 56 |
| Chengdu HappySyn Pharmaceutical Technology Co., Ltd. | 85114309 18982182443 | yangli@happysyn.com | China | 2283 | 55 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| INTATRADE GmbH | +49 3493/605464 | sales@intatrade.de | Germany | 3563 | 66 |
| New Energy Chemicals | 0515-82159099 13770142076 | info@njuchem.com | China | 251 | 65 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| ShangHai DEMO Chemical Co.,Ltd | 400-021-7337 2355568890 | sales@demochem.com | China | 2569 | 57 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| Beijing Ouhe Technology Co., Ltd | 13552068683 13522913783 | 2355560935@qq.com | China | 11777 | 60 |
| Jia Xing Isenchem Co.,Ltd | 0573-85285100 18627885956 | isenchem@163.com | China | 9389 | 66 |
View Lastest Price from 2-Amino-3-methoxybenzoic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-07-08 | 2-AMINO-3-METHOXYBENZOIC ACID
3177-80-8
|
$1.00 | 1Kg | 98% | 20T | Shaanxi Dideu Medichem Co. Ltd | |
 |
2019-07-06 | 2-AMINO-3-METHOXYBENZOIC ACID
3177-80-8
|
$1.00 | 1KG | 95% | 500KG | Career Henan Chemical Co |
-
- 2-AMINO-3-METHOXYBENZOIC ACID
3177-80-8
- $1.00
- 98%
- Shaanxi Dideu Medichem Co. Ltd
-
- 2-AMINO-3-METHOXYBENZOIC ACID
3177-80-8
- $1.00
- 95%
- Career Henan Chemical Co
3177-80-8(2-Amino-3-methoxybenzoic acid)Related Search:
1of4
