PD 145065
- CAS No.
- 153049-49-1
- Chemical Name:
- PD 145065
- Synonyms
- PD 145065;Ac-bhg-Leu-Asp-Ile-Ile-Trp;AC-DBHG-LEU-ASP-ILE-ILE-TRP;AC-D-BHG-LEU-ASP-ILE-ILE-TRP-OH;[AC-DBHG16] ENDOTHELIN-1 (16-21);Et receptor antagonist (Pd 145065);endothelin receptor antagonist*pd 145065;N-Acetyl-α-[10,11-Dihydro-5H-dibenzo[a,d]cycloheptadien-5-yl]-D-Gly-Leu-Asp-Ile-Ile-Trp;L-Tryptophan, N-[N-[N-[N-[N-[N-acetyl-D-2-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)glycyl]-L-leucyl]-L-α-aspartyl]-L-isoleucyl]-L-isoleucyl]- (9CI)
- CBNumber:
- CB7124466
- Molecular Formula:
- C52H67N7O10
- Molecular Weight:
- 950.13
- MDL Number:
- MFCD00467202
- MOL File:
- 153049-49-1.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Boiling point | 1252.069±65.00 °C(Press: 760.00 Torr)(predicted) |
|---|---|
| Density | 1.240±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) |
| storage temp. | −20°C |
| solubility | phosphate buffer, pH 7.5: 1mg/mL |
| form | White solid |
| pka | 3.389±0.10(predicted) |
| color | white |
| Sequence | Ac-{D-Bhg}-Leu-Asp-Ile-Ile-Trp-OH (Bhg = 5H-dibenzo[a,d]cycloheptene-5-glycine) |
| InChIKey | HRAQSWKGRRUBDJ-OMUAVVNCSA-N |
| UNSPSC Code | 12352200 |
PD 145065 price More Price(10)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 513020 | PD 145065 - CAS 153049-49-1 - Calbiochem | 153049-49-1 | 500μG | $166 | 2022-05-15 | Buy |
| Biosynth | DGA04949 | Et receptor antagonist (Pd 145065) | 153049-49-1 | 1mg | $614.67 | 2026-06-04 | Buy |
| Biosynth | DGA04949 | Et receptor antagonist (Pd 145065) | 153049-49-1 | 5mg | $1997.7 | 2026-06-04 | Buy |
| Biosynth | DGA04949 | Et receptor antagonist (Pd 145065) | 153049-49-1 | 10mg | $3196.4 | 2026-06-04 | Buy |
| Biosynth | DGA04949 | Et receptor antagonist (Pd 145065) | 153049-49-1 | 25mg | $5993.25 | 2026-06-04 | Buy |
PD 145065 Chemical Properties, Uses, Production
Uses
PD 145065 is a highly potent but non-selective endothelin receptor antagonist with an IC50 value of 4 nM for the ETA receptor for rabbit renal artery vascular smooth muscle cells[1].
Biological Activity
Cell permeable: no', 'Primary Target
Endothelin receptor antagonist', 'Product does not compete with ATP.', 'Reversible: no', 'Target IC50: 4 nM against endothelin receptor (ETA receptor) in rabbit renal artery vascular smooth muscle cells; 15 nM for the ETB receptor (r at cerebellum)
References
[1] Warner TD, et al. Reversal of established responses to endothelin-1 in vivo and in vitro by the endothelin receptor antagonists, BQ-123 and PD 145065. Br J Pharmacol. 1994 May;112(1):207-13. DOI:10.1111/j.1476-5381.1994.tb13053.x
PD 145065 Preparation Products And Raw materials
Raw materials
Preparation Products
PD 145065 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| GL Biochem (Shanghai) Ltd | 21-61263452 13641803416 | ymbetter@glbiochem.com | China | 9981 | 64 |
| Nanjing Peptide Biotech Ltd. | 025-58361106-805 15951641583 | zhao.xu@njpeptide.com | China | 9976 | 55 |
| Hangzhou Peptidego Biotech Co.,Ltd. | 0571-87213919 15967184799 | Eric@peptidego.com | China | 7872 | 58 |
| Nanjing Meihao Pharmaceutical Technology Co., Ltd. | meitaochem@126.com | meitaochem@126.com | China | 19087 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| Hangzhou Sinoda Pharmaceutical Technology Co. LTD | 0571-87213919 17306812703 | 3007955328@qq.com | China | 7446 | 58 |
| TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 29874 | 58 |
| Fuan Bio | 15002819872 | 2845971812@qq.com | China | 2103 | 58 |
