NSC63925
- CAS No.
- 20261-85-2
- Chemical Name:
- NSC63925
- Synonyms
- NSC63925;AKD 1C, S 3466A;5,23-Didemethyl-5,23-diethylnonactin;4,13,22,31,37,38,39,40-Octaoxapentacyclo[32.2.1.17,10.116,19.125,28]tetracontane-3,12,21,30-tetrone, 5,23-diethyl-2,11,14,20,29,32-hexamethyl-, (1R,2R,5R,7R,10S,11S,14S,16S,19R,20R,23R,25R,28S,29S,32S,34S)-
- CBNumber:
- CB71251059
- Molecular Formula:
- C42H68O12
- Molecular Weight:
- 764.98
- MDL Number:
- MFCD00950779
- MOL File:
- 20261-85-2.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| Dinactin ≥95% | 20752 | 1mg | $439 |
| Dinactin ≥95% | 20752 | 5mg | $1098 |
| Dinactin ≥95%(HPLC) | D3765 | 1mg | $589 |
| Dinactin | CS-0081462 | 1mg | $1079 |
| Dinactin | C3454 | 1mg | $619 |
| storage temp. | Store at -20°C |
|---|---|
| solubility | Soluble in DMSO |
| form | film |
| FDA UNII | BEN4Q6B74Y |
NSC63925 price More Price(10)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 20752 | Dinactin ≥95% | 20261-85-2 | 1mg | $439 | 2026-04-30 | Buy |
| Cayman Chemical | 20752 | Dinactin ≥95% | 20261-85-2 | 5mg | $1098 | 2026-04-30 | Buy |
| Usbiological | D3765 | Dinactin ≥95%(HPLC) | 20261-85-2 | 1mg | $589 | 2026-06-03 | Buy |
| ChemScene | CS-0081462 | Dinactin | 20261-85-2 | 1mg | $1079 | 2026-06-04 | Buy |
| ApexBio Technology | C3454 | Dinactin | 20261-85-2 | 1mg | $619 | 2026-05-06 | Buy |
NSC63925 Chemical Properties,Uses,Production
Description
Dinactin is a macrotetrolide antibiotic that acts as an ionophore for monovalent cations, such as K+, NH4+, and Rb+. It is commonly used to study membrane properties. Dinactin is a component of a macrotetralide-rich antifungal mixture produced by Streptomyces. Dinactin inhibits T-cell proliferation and cytokine production in vitro and reduces pulmonary eosinophilia in antigen-challenged mice.
Uses
Dinactin is a member of the macrotetrolide complex produced by a range of Streptomyces species. It is a monovalent cation ionophore with high selectivity for ammonium and potassium. Dinactin inhibits T-cell proliferation induced by IL-2 and cytokine production at nanomolar levels for IL-2, IL-4, IL-5 and interferon-γ. Dinactin has not previously been available for intensive investigation.
Uses
Dinactin is a hydrophobic cyclic ester that inhibits T-cell proliferation induced by IL-2.
in vitro
dinactin inhibited t-cell proliferation induced by il-2, by mab to cd3, and by mabs to cd3 plus α-cd28 with identical dose-response curves. the ic50 was 10–20 ng/ml. dinactin inhibited cytokine production with ic50 values of 10 ng/ml for il-4 and il-5, 30 or 60 ng/ml for interferong or il-2, respectively [3].dinactin inhibited cytokine production through a post-transcriptional mechanism. dinactin also reduced pulmonary eosinophilia when administered within 1 d of airway antigen challenge [3].
References
[1] laprade r, grenier f, pagé-dansereau m, et al. carrier-mediated ion transport in lipid bilayer membranes[j]. canadian journal of biochemistry and cell biology, 1984, 62(8): 738-751.
[2] silva l j, crevelin e j, souza w r, et al. streptomyces araujoniae produces a multiantibiotic complex with ionophoric properties to control botrytis cinerea[j]. phytopathology, 2014, 104(12): 1298-1305.
[3] umland s p, shah h, jakway j p, et al. effects of cyclosporin a and dinactin on t-cell proliferation, interleukin-5 production, and murine pulmonary inflammation[j]. american journal of respiratory cell and molecular biology, 1999, 20(3): 481-492.
NSC63925 Preparation Products And Raw materials
Raw materials
Preparation Products
NSC63925 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| BOC Sciences | 16314854226; +8616314854226 | inquiry@bocsci.com | United States | 19852 | 58 |
| Shenzhen Polymeri Biochemical Technology Co., Ltd. | +86-400-002-6226 | sales@rrkchem.com | China | 57336 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11123 | 58 |
| Energy Chemical | 400-0056266 | marketing1@energy-chemical.com | China | 44927 | 58 |
| Shanghai Saikerui Biotechnology Co. , Ltd. | 021-58000709 13120558703 | sales@scrbio.com | China | 9871 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 11963 | 58 |
| Shanghai Weiyite Biotechnology Co., Ltd | 15317051735 | zhaojing@wytsci.com | China | 10000 | 58 |
