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ChemicalBook >> CAS DataBase List >>1H-Indole-3-carboxylic acid, 1-ethyl-5-[4-(4-morpholinylmethyl)-2-thiazolyl]-, (2E)-2-[(3,4-difluorophenyl)methylene]hydrazide

1H-Indole-3-carboxylic acid, 1-ethyl-5-[4-(4-morpholinylmethyl)-2-thiazolyl]-, (2E)-2-[(3,4-difluorophenyl)methylene]hydrazide

1H-Indole-3-carboxylic acid, 1-ethyl-5-[4-(4-morpholinylmethyl)-2-thiazolyl]-, (2E)-2-[(3,4-difluorophenyl)methylene]hydrazide Structure
1H-Indole-3-carboxylic acid, 1-ethyl-5-[4-(4-morpholinylmethyl)-2-thiazolyl]-, (2E)-2-[(3,4-difluorophenyl)methylene]hydrazide structure
CAS No.
2691936-89-5
Chemical Name:
1H-Indole-3-carboxylic acid, 1-ethyl-5-[4-(4-morpholinylmethyl)-2-thiazolyl]-, (2E)-2-[(3,4-difluorophenyl)methylene]hydrazide
Synonyms
ATX inhibitor 21;1H-Indole-3-carboxylic acid, 1-ethyl-5-[4-(4-morpholinylmethyl)-2-thiazolyl]-, (2E)-2-[(3,4-difluorophenyl)methylene]hydrazide
CBNumber:
CB712773515
Molecular Formula:
C26H25F2N5O2S
Molecular Weight:
509.57
MDL Number:
MOL File:
2691936-89-5.mol
MSDS File:
SDS
Last updated:2026-05-11 15:21:01
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1H-Indole-3-carboxylic acid, 1-ethyl-5-[4-(4-morpholinylmethyl)-2-thiazolyl]-, (2E)-2-[(3,4-difluorophenyl)methylene]hydrazide Properties

Density 1.38±0.1 g/cm3(Predicted)
pka 11.32±0.46(Predicted)

1H-Indole-3-carboxylic acid, 1-ethyl-5-[4-(4-morpholinylmethyl)-2-thiazolyl]-, (2E)-2-[(3,4-difluorophenyl)methylene]hydrazide Chemical Properties, Uses, Production

Uses

ATX inhibitor 21 (compound 8) is a potent ATX (autotaxin) inhibitor, with an IC50 of 3490 nM[1].

IC 50

Autotaxin: 3490 ± 170 nM (IC50)

References

[1] Jia F, et al. Structure-based linker exploration: Discovery of 1-ethyl-1H-indole analogs as novel ATX inhibitors. Bioorg Med Chem. 2020 Nov 15;28(22):115795. DOI:10.1016/j.bmc.2020.115795

1H-Indole-3-carboxylic acid, 1-ethyl-5-[4-(4-morpholinylmethyl)-2-thiazolyl]-, (2E)-2-[(3,4-difluorophenyl)methylene]hydrazide Preparation Products And Raw materials

Raw materials

Preparation Products

1H-Indole-3-carboxylic acid, 1-ethyl-5-[4-(4-morpholinylmethyl)-2-thiazolyl]-, (2E)-2-[(3,4-difluorophenyl)methylene]hydrazide Suppliers

Global Suppliers ( 3)
Supplier Tel Email Country ProdList Advantage
Shandong Dayou Pharmaceutical Research and Development Co., Ltd. hanfangpharma@126.com 15165037910 hanfangpharma@126.com China 25800 58
TargetMol Chemicals Inc. 15002134094 marketing@targetmol.cn China 29874 58
TargetMol Chemicals Inc. 13564774135 marketing@targetmol.com United States 19950 58
Supplier Advantage
Shandong Dayou Pharmaceutical Research and Development Co., Ltd. 58
TargetMol Chemicals Inc. 58
TargetMol Chemicals Inc. 58

View Latest Price from 1H-Indole-3-carboxylic acid, 1-ethyl-5-[4-(4-morpholinylmethyl)-2-thiazolyl]-, (2E)-2-[(3,4-difluorophenyl)methylene]hydrazide manufacturers

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ATX inhibitor 21 pictures 2026-05-11 ATX inhibitor 21
2691936-89-5
 $1520.00-2500.00 10g TargetMol Chemicals Inc.

2691936-89-5 (1H-Indole-3-carboxylic acid, 1-ethyl-5-[4-(4-morpholinylmethyl)-2-thiazolyl]-, (2E)-2-[(3,4-difluorophenyl)methylene]hydrazide) Related Search:

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ATX inhibitor 21 1H-Indole-3-carboxylic acid, 1-ethyl-5-[4-(4-morpholinylmethyl)-2-thiazolyl]-, (2E)-2-[(3,4-difluorophenyl)methylene]hydrazide 2691936-89-5 C26H25F2N5O2S