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fulvine

fulvine Structure
fulvine structure
CAS No.
6029-87-4
Chemical Name:
fulvine
Synonyms
fulvine;Nsc 89932;Brn 1088365;Fulvine (8ci);13-Epicrispatine;20-Norcrotalanan-11,15-dione, 14,19-dihydro-13-hydroxy-, (12-xi,13-xi)-;2H-[1,6]Dioxacycloundecino[2,3,4-gh]pyrrolizine-2,6(3H)-dione, 4,5,8,10,12,13,13a,13b-octahydro-4-hydroxy-3,4,5-trimethyl-, (3R,4S,5S,13aR,13bR)- (9CI)
CBNumber:
CB71365589
Molecular Formula:
C16H23NO5
Molecular Weight:
309.36
MDL Number:
MFCD01711366
MOL File:
6029-87-4.mol
MSDS File:
SDS
Last updated:2026-05-28 03:03:35
Product description Number Pack Size Price
Fulvine ≥98% 380314 5mg $766
Fulvine GAA02987 5mg $752
Fulvine GAA02987 10mg $1203.1
Fulvine GAA02987 25mg $1961.75
Fulvine GAA02987 50mg $3139
Request For Quotation

fulvine Properties

Melting point 212.5°C
Boiling point 449.63°C (rough estimate)
Density 1.1188 (rough estimate)
refractive index 1.5500 (estimate)
pka 13.53±0.60(Predicted)
EWG's Food Scores 1
FDA UNII R3MQ366VXD

SAFETY

Risk and Safety Statements

Symbol(GHS)  Health Hazard (GHS08)Skull and Crossbones (GHS06)
GHS08,GHS06
Signal word  Danger
Hazard statements  H301-H373
Precautionary statements  P264-P270-P301+P310-P321-P330-P405-P501-P260-P314-P501

fulvine price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Usbiological 380314 Fulvine ≥98% 6029-87-4 5mg $766 2026-06-03 Buy
Biosynth GAA02987 Fulvine 6029-87-4 5mg $752 2026-06-04 Buy
Biosynth GAA02987 Fulvine 6029-87-4 10mg $1203.1 2026-06-04 Buy
Biosynth GAA02987 Fulvine 6029-87-4 25mg $1961.75 2026-06-04 Buy
Biosynth GAA02987 Fulvine 6029-87-4 50mg $3139 2026-06-04 Buy
Product number Packaging Price Buy
380314 5mg $766 Buy
GAA02987 5mg $752 Buy
GAA02987 10mg $1203.1 Buy
GAA02987 25mg $1961.75 Buy
GAA02987 50mg $3139 Buy

fulvine Chemical Properties,Uses,Production

Uses

Fulvine is a pyrrolizidine alkaloid isolated from the seeds of Crotalaria fulva. Fulvine is hepatotoxic and can be used to induce hypertensive pulmonary vascular disease in vivo[1].

Definition

ChEBI: Fulvine is a member of pyrrolizines.

Safety Profile

Poison by intraperitoneal route. Experimental teratogenic and reproductive effects. Mutation data reported. When heated to decomposition it emits toxic fumes of NOx.

in vivo

Fulvine can be used in animal modeling to create respiratory disease models[1][2].

Induction of respiratory and liver disease[1][2].
Background
Fulvine on reaching the liver is metabolically converted into a cellular toxin. Some of this toxin is retained in the hepatic cells, and produces necrosis and other cellular changes. Some of the toxin escapes to damage the vascular endothelium in the hepatic veins. This may take the form of endothelial proliferation with the later changes characteristic of veno-occlusion. Carried further, the escaping toxic metabolites reach the pulmonary tissues to produce vascular changes with increased capillary permeability and progressive oedema and cellular changes in the lungs, including the development of the big cells and the accumulation of mast cells[2].
Specific Modeling Methods
Rat: White SPF and conventional Male and Female weighing 50-65 g and 45-60 g[1]
Administration: 30-45 mg/kg neutralised aqueous solution by stomach tube a single dose[1]
Rat: Male and Female weighing 40-80 g[2]
Administration: 50 mg/kg given by stomach tube a single dose[2]
Note
(1)SPF rats and conventional rats were kept separately. All were weighed at least weekly. Rats that died or were killed with coal-gas when ill were examined post mortem. Lungs, liver and other tissues from representative animals were fixed in Hefly’s fluid; paraffin sections were stained with haematoxylin and eosin[1]
.
Crystalline Fulvine was dissolved in dilute hydrochloric acid, neutralised and diluted to give a 1% solution[2]
.
Modeling Indicators
Pathology change: The lungs were congested or oedematous and did not collapse when the chest was opened, showing petechiae or small dark red patches. Large often bloodstained, effusions were present in many rats. The liver appeared enlarged, dark red with a brownish tint, slightly granular and rubbery. The heart seemed enlarged; some rats had gastro-intestinal haemorrhage and prominent red lymph-glands. Varying degrees of ascites were present, and the ventral skin was often oedematous[1]
.
Behavioral observation: Fulvine induced some developed difficulty in breathing and slowing or cessation of growth in rats[1]
.
Histological analysis: Fulvine induced moderate ascites, well marked fibrous thickening of the central vein walls, endothelial proliferation and some perivascular centrilobular fibrosis with possibly partial venous occlusion[2]
.
Correlated Product(s): Monocrotaline (HY-N0750); Crispatine
Opposite Product(s): /

References

[1] Schoental R. Rat lung lesions due to Fulvine. J Pathol Bacteriol. 1966 Apr;91(2):629-31. DOI:10.1002/path.1700910246
[2] BARNES JM, et al. LESIONS IN THE LUNGS AND LIVERS OF RATS POISONED WITH THE PYRROLIZIDINE ALKALOID Fulvine AND ITS N-OXIDE. J Pathol Bacteriol. 1964 Oct;88:521-31. DOI:10.1002/path.1700880215
[3] J M Kay, et al.Fulvine and the pulmonary circulation. Thorax DOI:10.1136/thx.26.3.249

fulvine Preparation Products And Raw materials

Raw materials

Preparation Products

fulvine Suppliers

Global( 10)Suppliers
Supplier Tel Email Country ProdList Advantage
Wuhan ChemFaces Biochemical Co., Ltd. 18607101326 15172504745 aileen@chemfaces.com China 6905 55
EMMX Biotechnology LLC 888-539-0666 info@emmx.com United States 8447 60
Hubei Baidu Chemical Co., Ltd 027-59106051 13627137652 1438180055@qq.com China 8469 58
Hubei Guangao Biotechnology Co., Ltd 027-02702759223056 18162699093 1208480011@qq.com China 9506 58
Hubei Qifei Pharmaceutical Chemical Co., Ltd 59322506 18071128681 1438082200@qq.com China 9555 58
Chengdu Peter-like Biotechnology Co., Ltd. 028-81700200 13308200041 2851167782@qq.com China 10933 58
Biosynth Biological Technology (Suzhou) Co Ltd -- sales@biosynth.com China 6051 58
Wuhan Zhongzhicheng Biotechnology Co., Ltd. 13628624121 13628604890 1205052329@qq.com China 9955 58
Supplier Advantage
Wuhan ChemFaces Biochemical Co., Ltd. 55
EMMX Biotechnology LLC 60
Hubei Baidu Chemical Co., Ltd 58
Hubei Guangao Biotechnology Co., Ltd 58
Hubei Qifei Pharmaceutical Chemical Co., Ltd 58
Chengdu Peter-like Biotechnology Co., Ltd. 58
Biosynth Biological Technology (Suzhou) Co Ltd 58
Wuhan Zhongzhicheng Biotechnology Co., Ltd. 58

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fulvine 13-Epicrispatine 20-Norcrotalanan-11,15-dione, 14,19-dihydro-13-hydroxy-, (12-xi,13-xi)- Brn 1088365 Fulvine (8ci) Nsc 89932 2H-[1,6]Dioxacycloundecino[2,3,4-gh]pyrrolizine-2,6(3H)-dione, 4,5,8,10,12,13,13a,13b-octahydro-4-hydroxy-3,4,5-trimethyl-, (3R,4S,5S,13aR,13bR)- (9CI) 6029-87-4