glucopiericidin A
- CAS No.
- 108073-65-0
- Chemical Name:
- glucopiericidin A
- Synonyms
- CBNumber:
- CB71378053
- Molecular Formula:
- C31H47NO9
- Molecular Weight:
- 577.71
- MDL Number:
- MFCD01725340
- MOL File:
- 108073-65-0.mol
| Product description | Number | Pack Size | Price |
| GLUCOPIERICIDIN A 95.00% | INB0003868 | 5MG | $503.48 |
glucopiericidin A Chemical Properties,Uses,Production
Uses
Glucopiericidin A is a natural piericidin compound obtained from a marine-derived Streptomyces strain. Glucopiericidin A serves as a glucose transporter (GLUT) chemical probe and suppresses glycolysis. Glucopiericidin A inhibits ATP-dependent filopodia protrusion with Piericidin A (PA; HY-114936) and has no effect alone. Glucopiericidin A induces cell apoptosis through reducing the reactive oxygen species (ROS) level by increasing PRDX1 and exhibits potent antitumor efficacy in ACHN mice xenografts[1][2].
in vivo
Glucopiericidin A (0.8 mg/kg/day; IP; for three weeks) significantly reduces the final tumor weight of the mice[2].
| Animal Model: | Nude mice bearing ACHN tumor xenografts[2] |
| Dosage: | 0.8 mg/kg |
| Administration: | IP; daily; for three weeks |
| Result: | Significantly reduced the final tumor weight of the mice. Increased the mRNA and protein expression of PRDX1 in tumor tissues. |
References
[1] Mitsuhiro Kitagawa, et al. Metabolomic identification of the target of the filopodia protrusion inhibitor glucopiericidin A. Chem Biol. 2010 Sep 24;17(9):989-98. DOI:10.1016/j.chembiol.2010.06.017
[2] Xuefeng Zhou, et al. Exploring the Natural Piericidins as Anti-Renal Cell Carcinoma Agents Targeting Peroxiredoxin 1. J Med Chem. 2019 Aug 8;62(15):7058-7069. DOI:10.1021/acs.jmedchem.9b00598
glucopiericidin A Preparation Products And Raw materials
Raw materials
Preparation Products
glucopiericidin A Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| BOC Sciences | 16314854226; +16314854226 | inquiry@bocsci.com | United States | 19853 | 58 |
| Beijing Jin Ming Biotechnology Co., Ltd. | 010-60605840 18892239720 | psaitong@jm-bio.com | China | 12306 | 58 |
| Zhejiang Huida Biotech Co., LTD | 0571-89903882 18679456698 | zilong@hizyme.com | China | 2976 | 58 |
| Beijing Jin Ming Biotechnology Co., Ltd. | 010-60605840 15801484223; | psaitong@jm-bio.com | China | 29757 | 58 |
| Zhejiang Huida Biotech Co., LTD | 0571-0571-89903882 15990081639 | sunshixuan@huidabiotech.com | China | 3705 | 58 |
| RD International Technology Co., Limited | 18024082417 | market@ubiochem.com | China | 9835 | 58 |
