glucopiericidin A

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glucopiericidin A Basic information
Product Name:glucopiericidin A
Synonyms:
CAS:108073-65-0
MF:C31H47NO9
MW:577.71
EINECS:
Product Categories:
Mol File:108073-65-0.mol
glucopiericidin A Structure
glucopiericidin A Chemical Properties
Safety Information
MSDS Information
glucopiericidin A Usage And Synthesis
UsesGlucopiericidin A is a natural piericidin compound obtained from a marine-derived Streptomyces strain. Glucopiericidin A serves as a glucose transporter (GLUT) chemical probe and suppresses glycolysis. Glucopiericidin A inhibits ATP-dependent filopodia protrusion with Piericidin A (PA; HY-114936) and has no effect alone. Glucopiericidin A induces cell apoptosis through reducing the reactive oxygen species (ROS) level by increasing PRDX1 and exhibits potent antitumor efficacy in ACHN mice xenografts[1][2].
in vivo

Glucopiericidin A (0.8 mg/kg/day; IP; for three weeks) significantly reduces the final tumor weight of the mice[2].

Animal Model:Nude mice bearing ACHN tumor xenografts[2]
Dosage:0.8 mg/kg
Administration:IP; daily; for three weeks
Result:Significantly reduced the final tumor weight of the mice.
Increased the mRNA and protein expression of PRDX1 in tumor tissues.
References[1] Mitsuhiro Kitagawa, et al. Metabolomic identification of the target of the filopodia protrusion inhibitor glucopiericidin A. Chem Biol. 2010 Sep 24;17(9):989-98. DOI:10.1016/j.chembiol.2010.06.017
[2] Xuefeng Zhou, et al. Exploring the Natural Piericidins as Anti-Renal Cell Carcinoma Agents Targeting Peroxiredoxin 1. J Med Chem. 2019 Aug 8;62(15):7058-7069. DOI:10.1021/acs.jmedchem.9b00598
glucopiericidin A Preparation Products And Raw materials
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5,7-Octadien-2-ol, 2,6-dimethyl 2,4-Dihydroxy-6-methylpyridine 2-Methoxy-5-picoline 2,3-Dimethoxypyridine 3,4-Dihydroxypyridine 4-Hydroxy-2,3-dimethoxypyridine 2(1H)-Pyridinone,4-hydroxy-5-methyl-(9CI) 2,3-Dihydroxypyridine glucopiericidin A