MS-39
- CAS No.
- 2675490-92-1
- Chemical Name:
- MS-39
- Synonyms
- L-Prolinamide, N-[11-[4-[3-[[4-[(3-chloro-4-fluorophenyl)amino]-7-methoxy-6-quinazolinyl]oxy]propyl]-1-piperazinyl]-1,11-dioxoundecyl]-3-methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-, (4R)-;(2S,4R)-1-((S)-2-(11-(4-(3-((4-((3-Chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)propyl)piperazin-1-yl)-11-oxoundecanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide
- CBNumber:
- CB714129356
- Molecular Formula:
- C55H71ClFN9O7S
- Molecular Weight:
- 1056.73
- MDL Number:
- MOL File:
- 2675490-92-1.mol
- MSDS File:
- SDS
- TDS File:
- TDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319 |
| Precautionary statements | P501-P270-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330 |
MS-39 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-0996166 | MS39 99.89% | 2675490-92-1 | 1mg | $217 | 2026-06-04 | Buy |
| ChemScene | CS-0996166 | MS39 99.89% | 2675490-92-1 | 5mg | $433 | 2026-06-04 | Buy |
| ChemScene | CS-0996166 | MS39 99.89% | 2675490-92-1 | 10mg | $704 | 2026-06-04 | Buy |
| ChemScene | CS-0996166 | MS39 99.89% | 2675490-92-1 | 25mg | $1408 | 2026-06-04 | Buy |
| ChemScene | CS-0996166 | MS39 99.89% | 2675490-92-1 | 50mg | $2275 | 2026-06-04 | Buy |
MS-39 Chemical Properties, Uses, Production
Uses
MS39 (compound 6) is a PROTAC targeting EGFR. MS39 is composed of PROTAC target protein ligand N-(3-Chloro-4-fluorophenyl)-7-methoxy-6-(3-(piperazin-1-yl)propoxy)quinazolin-4-amine (HY-W109039) (red part), E3 ligase ligand (S,R,S)-AHPC (HY-125845) (blue part) and PROTAC Linker Undecanedioic acid (HY-W014125) (black part), among which the conjugate of E3 ubiquitin ligase ligand + Linker is (S,R,S)-AHPC-CO-C9-acid (HY-139345). MS39 reduces the expression of EGFR and downstream signaling in HCC-827 and H3255 cells. MS39 inhibits the proliferation of H3255 cells[1].
References
[1] Cheng M, et al. Discovery of Potent and Selective Epidermal Growth Factor Receptor (EGFR) Bifunctional Small-Molecule Degraders. J Med Chem. 2020 Feb 13;63(3):1216-1232. DOI:10.1021/acs.jmedchem.9b01566
MS-39 Preparation Products And Raw materials
Raw materials
Preparation Products
MS-39 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Tianjin Kailiqi Biotechnology Co., Ltd. | 15076683720 | klq@cw-bio.com | China | 9777 | 55 |
| Nantong QuanYi Biotechnology Co., Ltd | 0513-66337626 18051384581 | sales@chemhifuture.com | China | 5985 | 58 |
| Jilin Chinese Academy of Sciences-yanshen Technology | 18143011203 | ET-market@chemextension.com | China | 38921 | 58 |
| Shandong Dayou Pharmaceutical Research and Development Co., Ltd. | hanfangpharma@126.com 15165037910 | hanfangpharma@126.com | China | 25800 | 58 |
| TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 29873 | 58 |
| Aikon International Limited | 025-58859352 18651614124 | 2881516338@qq.com | China | 9968 | 58 |
| Henan Inokai New Materials Co., Ltd | 15090072163 | 3921118937@qq.com | China | 2676 | 58 |
| Guangzhou Ruidi Biotechnology Co., Ltd. | 020-82099279 18988941402 | sales@ubiochem.com | China | 9998 | 58 |
