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2-Oxazolidone

2-Oxazolidone Structure
2-Oxazolidone structure
CAS No.
497-25-6
Chemical Name:
2-Oxazolidone
Synonyms
oxazolidin-2-one;Oxazolidine;2-OXAZOLIDINONE;Oxazolidone;NSC 35382;2-Oxazolinone;2-OXAZOLIDIONE;1,3-Oxazolidin-2-one;2-OX;2-Oxa
CBNumber:
CB7141597
Molecular Formula:
C3H5NO2
Molecular Weight:
87.08
MDL Number:
MFCD00005268
MOL File:
497-25-6.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-06-23 18:08:44
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2-Oxazolidone Properties

Melting point 83-87 °C(lit.)
Boiling point 220 °C48 mm Hg(lit.)
Density 1.2736 (rough estimate)
refractive index 1.4940 (estimate)
Flash point 220°C/48mm
storage temp. Sealed in dry,Room Temperature
solubility Chloroform (Slightly, Heated), Methanol (Slightly)
pka 12.78±0.20(Predicted)
form Crystals or Powder
color Off-white to yellow-beige
Water Solubility Soluble in water.
BRN 106251
InChI 1S/C3H5NO2/c5-3-4-1-2-6-3/h1-2H2,(H,4,5)
InChIKey IZXIZTKNFFYFOF-UHFFFAOYSA-N
SMILES O=C1NCCO1
CAS DataBase Reference 497-25-6(CAS DataBase Reference)
EWG's Food Scores 1
FDA UNII Z4D49W92PP
NIST Chemistry Reference Oxazolidin-2-one(497-25-6)
EPA Substance Registry System 2-Oxazolidinone (497-25-6)
UNSPSC Code 12352100
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302-H317-H319-H315-H335
Precautionary statements  P280-P305+P351+P338-P261-P280a-P304+P340-P405-P501a
PPE dust mask type N95 (US), Eyeshields, Faceshields, Gloves
Hazard Codes  Xn,Xi
Risk Statements  22-36-43-40-36/37/38
Safety Statements  26-36/37-37-36
WGK Germany  3
RTECS  RQ2450000
TSCA  TSCA listed
HS Code  29322980
Storage Class 13 - Non Combustible Solids
Toxicity TDLo orl-mus: 1000 mg/kg:ETA BCPCA62,168,59
NFPA 704
1
1 0

2-Oxazolidone price More Price(49)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich O9409 2-Oxazolidinone 98% 497-25-6 5g $40.3 2026-04-30 Buy
Sigma-Aldrich O9409 2-Oxazolidinone 98% 497-25-6 25g $53.1 2026-04-30 Buy
TCI Chemical O0188 2-Oxazolidone >98.0%(GC) 497-25-6 25g $26 2026-04-30 Buy
TCI Chemical O0188 2-Oxazolidone >98.0%(GC) 497-25-6 100g $81 2026-04-30 Buy
TRC TRC-O846535-10G 2-Oxazolidinone 497-25-6 10g $70 2026-06-03 Buy
Product number Packaging Price Buy
O9409 5g $40.3 Buy
O9409 25g $53.1 Buy
O0188 25g $26 Buy
O0188 100g $81 Buy
TRC-O846535-10G 10g $70 Buy

2-Oxazolidone Chemical Properties,Uses,Production

Chemical Properties

off-white to yellow-beige crystals or powder

Uses

As an oxazole derivative used as an antibiotic, 2-Oxazolidone is also used in the preparation of compounds with antitumor activity and as a metabolite of Furazolidone (F864100).

Uses

An oxazole derivative used as an antibiotic. It is also used in the preparation of compounds with antitumor activity. A metabolite of Furazolidone (F864100).

Definition

ChEBI: An oxazolidinone that is 1,3-oxazolidine with an oxo substituent at position 2.

Safety Profile

Questionable carcinogen with experimental tumorigenic data. When heated to decomposition it emits toxic fumes of NOx.

Synthesis

2-Oxazolidinone is synthesized by the following methods: 1) electrolytic cyclization and oxidation of hydroxyethyl formamide; 2) reaction of aminoethanol with CO2 gas; 3) reaction of epoxide with cyanuric acid or urea; 4) reaction of acrolein with isocyanate; 5) reaction of aziridine with CO2 gas; 6) reaction of -hydroxyethyl carbamate with urea; 7) reaction of aminoethanol with urea etc.

Purification Methods

Crystallise it from *benzene, dichloroethane, CHCl3 or EtOH. It is a cyclic urethane, and as such it is not very stable. [Katritzky et al. J Chem Soc Perkin II 145 1990, Beilstein 27 H 135, 27 II 259, 27 III/IV 2516.]

2-Oxazolidone synthesis

124-38-9
141-43-5
497-25-6
Synthesis of 2-Oxazolidone from Carbon dioxide and Monoethanolamine

2-Oxazolidone Preparation Products And Raw materials

Raw materials

Monoethanolamine Ethenimine (9CI) N-Benzyloxybenzamide 2-Oxazolidinone,3-benzoyl- 2-bromoethylamine
O-Benzylhydroxylamine Propargylamine Urethane 3-Trimethylsilyl-2-oxazolidinone 1-(Trimethylsiloxy)cyclopentene

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Preparation Products

Lomustine N,N'-bis-(2-Chloroethyl)urea 3-Amino-2-oxazolidinone Furazolidone 2-Chloroethyl isocyanate
3,4-Methylenedioxyphenethylamine hydrochloride

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2-Oxazolidone Suppliers

Global( 347)Suppliers
Supplier Tel Email Country ProdList Advantage
Ningbo Chemrio Chemtech Co,.Ltd. 0574-27891269 18667892864 frank.xiaodong@chemriotech.com China 3933 58
Sichuan Hainuowei Technology Co. Ltd. 13708085536 13708085536 hanovichem@163.com China 3268 56
Zhengzhou HongSheng Pharmaceutical Co., Ltd. 0371-0371-13526885213 15637198702 hsyykjchem@163.com China 1856 58
Shanghai Birch Chemical Technology Co., Ltd. 021-54096810 18017263450 sales@birchchem.com China 500 58
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 4006356688 18621169109 market03@meryer.com China 40202 62
Alfa Aesar 400-6106006 saleschina@alfa-asia.com China 30103 84
TCI (Shanghai) Development Co., Ltd. 021-67121386 Sales-CN@TCIchemicals.com China 24512 81
Beijing HwrkChemical Technology Co., Ltd 89508211 18501085097 sales.bj@hwrkchemical.com China 9407 55
Energy Chemical 400-0056266 sales8178@energy-chemical.com China 44850 61
Supplier Advantage
Ningbo Chemrio Chemtech Co,.Ltd. 58
Sichuan Hainuowei Technology Co. Ltd. 56
Zhengzhou HongSheng Pharmaceutical Co., Ltd. 58
Shanghai Birch Chemical Technology Co., Ltd. 58
J & K SCIENTIFIC LTD. 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 62
Alfa Aesar 84
TCI (Shanghai) Development Co., Ltd. 81
Beijing HwrkChemical Technology Co., Ltd 55
Energy Chemical 61

Related articles

View Lastest Price from 2-Oxazolidone manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2-Oxazolidone pictures 2026-06-30 2-Oxazolidone
497-25-6
 1kg 98% 1000kg Shaanxi Dideu New Materials Co. Ltd
2-Oxazolidone pictures 2026-05-28 2-Oxazolidone
497-25-6
 $10.00 1kg 98% 10 ton Hebei Chuanghai Biotechnology Co,.LTD
2-Oxazolidone pictures 2026-03-20 2-Oxazolidone
497-25-6
 $10.00 1KG 99% 100 mt Hebei Chuanghai Biotechnology Co., Ltd
  • 2-Oxazolidone pictures
  • 2-Oxazolidone
    497-25-6
  • $10.00
  • 98%
  • Hebei Chuanghai Biotechnology Co,.LTD
  • 2-Oxazolidone pictures
  • 2-Oxazolidone
    497-25-6
  • $10.00
  • 99%
  • Hebei Chuanghai Biotechnology Co., Ltd

2-Oxazolidone Spectrum

2-Oxazolidone(497-25-6)MS2-Oxazolidone(497-25-6)1HNMR2-Oxazolidone(497-25-6)13CNMR2-Oxazolidone(497-25-6)IR12-Oxazolidone(497-25-6)IR22-Oxazolidone(497-25-6)Raman

497-25-6(2-Oxazolidone )Related Search:

Oxadixyl 3-Acetyl-1-chlorocarbonyl-2-imidazolidone 3-Methyl-2-oxazolidone Bis(2-oxo-3-oxazolidinyl)phosphinic chloride (4R,5S)-(+)-4-Methyl-5-phenyl-2-oxazolidinone
(S)-(+)-4-Isopropyl-3-propionyl-2-oxazolidinone S-4-Isopropyl-2-oxazolidone 5,5-Dimethyloxazolidine-2,4-dione Furazolidone (R)-4-Benzyl-2-oxazolidinone
3-Phenyl-2-oxazolidinone 3-Amino-2-oxazolidinone S-4-Phenyl-2-oxazolidonone 3-(2-Hydroxyethyl)-2-oxazolidinone 5-Chloromethyl-2-oxazolidinone
3-Trimethylsilyl-2-oxazolidinone Nifuratel (R)-(-)-4-Phenyl-2-oxazolidinone

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2-Oxotetrahydro-1,3-oxazole 2-Oxazolinone 2-Oxazolidone,98% 2-Oxazolidone, 98% 100GR 2-Oxazolidone, 98% 25GR 2-Oxo-1,3-oxazolidine NSC 35382 NSC 38240 2-Oxazolidinone≥ 99%(GC) 2H-oxazol-2-id-4-one (2-hydroxyethyl)-carbamicacigamma-lactone 2-Oxazolidine Carbamic acid, (2-hydroxyethyl)-, gamma-lactone 2-OX 2-OXAZOLIDONE 2-Oxazolidinone,99% 2-OXAZOLIDIONE (2-hydroxyethyl)-carbamic acid gamma-lactone 2-OXAZOLIDINONE 98% 2-OxazoL 2-Oxazolidone> 2-Oxazolidinone, 98%, for synthesis Levetiracetam Impurity 45 2-Oxazolidinone (7CI, 8CI, 9CI, ACI) (4S,4′S)-4,4′-[[4-(dimethylamino)butane-1,1-diyl]bis[[3-[2-(dimethylamino)ethyl]-1H-indole-2,5-diyl]methylene]]bis(1,3-oxazolidin-2-one) 2-Oxa Oxazolidone 1,3-Oxazolidin-2-one 2-OXAZOLIDINONE Oxazolidine oxazolidin-2-one 497-25-6 495-25-6 C3H5NO2 Oxazolines/Oxazolidines Heterocyclic Building Blocks Building Blocks Building Blocks Heterocyclic Building Blocks Oxazolines/Oxazolidines Building Blocks Chemical Synthesis Heterocyclic Building Blocks Heterocycles Intermediates & Fine Chemicals Pharmaceuticals Heterocyclic Compounds