2-Methyl-3-((2S)-pyrrolidin-2-ylmethoxy)pyridine
- CAS No.
- 161417-03-4
- Chemical Name:
- 2-Methyl-3-((2S)-pyrrolidin-2-ylmethoxy)pyridine
- Synonyms
- Abt-089;A 87089.0;Pozanicline;Unii-cl2002R563;ABT-089 (ABT089;Pozanicline(freebase);2-Methyl-3-(2S-pyrrolidinylmethoxy)pyridine;(S)-3-(2-pyrrolidinylmethoxy)-2-picoline 2HCl;2-Methyl-3-((2S)-pyrrolidin-2-ylmethoxy)pyridine;Pyridine, 2-methyl-3-((2S)-2-pyrrolidinylmethoxy)-
- CBNumber:
- CB71473552
- Molecular Formula:
- C11H16N2O
- Molecular Weight:
- 192.26
- MDL Number:
- MFCD11974724
- MOL File:
- 161417-03-4.mol
- MSDS File:
- SDS
| Boiling point | 302.7±22.0 °C(Predicted) |
|---|---|
| Density | 1.046±0.06 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | Soluble in DMSO |
| pka | 9.99±0.10(Predicted) |
| FDA UNII | CL2002R563 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P280-P305+P351+P338 |
2-Methyl-3-((2S)-pyrrolidin-2-ylmethoxy)pyridine price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| aablocks | AA001SDO | 2-methyl-3-{[(2S)-pyrrolidin-2-yl]methoxy}pyridine 97% | 161417-03-4 | 100mg | $138 | 2026-05-28 | Buy |
| aablocks | AA001SDO | 2-methyl-3-{[(2S)-pyrrolidin-2-yl]methoxy}pyridine 97% | 161417-03-4 | 250mg | $260 | 2026-05-28 | Buy |
| aablocks | AA001SDO | 2-methyl-3-{[(2S)-pyrrolidin-2-yl]methoxy}pyridine 97% | 161417-03-4 | 500mg | $390 | 2026-05-28 | Buy |
| ACHEMBLOCK | V152919 | (S)-2-Methyl-3-(2-pyrrolidinylmethoxy)pyridine dihydrochloride 95% | 161417-03-4 | 250MG | $335 | 2026-05-27 | Buy |
| ACHEMBLOCK | V152919 | (S)-2-Methyl-3-(2-pyrrolidinylmethoxy)pyridine dihydrochloride 95% | 161417-03-4 | 1G | $1005 | 2026-05-27 | Buy |
2-Methyl-3-((2S)-pyrrolidin-2-ylmethoxy)pyridine Chemical Properties, Uses, Production
Uses
Pozanicline (ABT-089) selectively activate neuronal nicotinic acetylcholine receptor (nAChR) subtypes, is a novel cholinergic agent that is a partial agonist at α4β2* nAChRs (Ki=16 nM) and shows high selectivity for α6β2* and α4α5β2 nAChR subtypes, the binding affinity (Ki, rat) for Pozanicline to [3H] cytisine sites is 16.7 nM. Pozanicline reverses nicotine withdrawal-induced cognitive deficits, may be an effective component of novel therapeutic strategies for nicotine addiction[1].
References
[1] Sullivan JP, et al. ABT-089 [2-methyl-3-(2-(S)-pyrrolidinylmethoxy)pyridine]: I. A potent and selective cholinergic channel modulator with neuroprotective properties. J Pharmacol Exp Ther. 1997 Oct;283(1):235-46. PMID:9336329
[2] Yildirim E, et al. ABT-089, but not ABT-107, ameliorates nicotine withdrawal-induced cognitive deficits in C57BL6/J mice. Behav Pharmacol. 2015 Apr;26(3):241-8. DOI:10.1097/FBP.0000000000000111
2-Methyl-3-((2S)-pyrrolidin-2-ylmethoxy)pyridine Preparation Products And Raw materials
Raw materials
Preparation Products
2-Methyl-3-((2S)-pyrrolidin-2-ylmethoxy)pyridine Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| BOC Sciences | 1-631-485-4226; 16314854226 | info@bocsci.com | United States | 9920 | 65 |
| Amatek Scientific Co. Ltd. | 0512-56316828 4008675858 | sales@amateksci.com | China | 9849 | 55 |
| Fan De(Beijing) Biotechnology Co., Ltd. | 15911056312 | liming@bio-fount.com | China | 9718 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| Jiangsu yize medical technology co. LTD | 18550739526 | 23903480@qq.com | China | 5837 | 58 |
| Haiji Pharmaceutical Technology (Suzhou) Co., Ltd | 18012778619 | 3394205705@qq.com | China | 9824 | 58 |
| cjbscvictory | 13348960310 13348960310 | 3003867561@qq.com | China | 10233 | 58 |
| Beijing Jin Ming Biotechnology Co., Ltd. | 010-60605840 | psaitong@jm-bio.com | China | 27626 | 58 |
| TargetMol Chemicals Inc. | 4008200310 15002144251 | marketing@tsbiochem.com | China | 24951 | 58 |
| Suzhou Zhixin Biotechnology Co., Ltd. | 0512-65118909 18100677375 | sales@szzxbio.com | China | 1129 | 58 |
View Latest Price from 2-Methyl-3-((2S)-pyrrolidin-2-ylmethoxy)pyridine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-05-11 | Pozanicline
161417-03-4
|
$1520.00-2500.00 | 10g | TargetMol Chemicals Inc. |
-
- Pozanicline
161417-03-4
- $1520.00-2500.00
- TargetMol Chemicals Inc.
