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2-Methyl-3-((2S)-pyrrolidin-2-ylmethoxy)pyridine

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2-Methyl-3-((2S)-pyrrolidin-2-ylmethoxy)pyridine manufacturers

  • Pozanicline
  • Pozanicline pictures
  • $1520.00
  • 2026-05-11
  • CAS:161417-03-4
  • Purity:
  • Supply Ability: 10g
2-Methyl-3-((2S)-pyrrolidin-2-ylmethoxy)pyridine Basic information
Product Name:2-Methyl-3-((2S)-pyrrolidin-2-ylmethoxy)pyridine
Synonyms:2-Methyl-3-(2S-pyrrolidinylmethoxy)pyridine;Pyridine, 2-methyl-3-((2S)-2-pyrrolidinylmethoxy)-;Pyridine, 2-methyl-3-(2-pyrrolidinylmethoxy)-, (S)-;Unii-cl2002R563;A 87089.0;Pozanicline;(S)-3-(2-pyrrolidinylmethoxy)-2-picoline 2HCl;(S)-3-(2-pyrrolidinylmethoxy)-2-picoline dihydrochloride
CAS:161417-03-4
MF:C11H16N2O
MW:192.26
EINECS:
Product Categories:
Mol File:161417-03-4.mol
2-Methyl-3-((2S)-pyrrolidin-2-ylmethoxy)pyridine Structure
2-Methyl-3-((2S)-pyrrolidin-2-ylmethoxy)pyridine Chemical Properties
Boiling point 302.7±22.0 °C(Predicted)
density 1.046±0.06 g/cm3(Predicted)
storage temp. Store at -20°C
solubility Soluble in DMSO
pka9.99±0.10(Predicted)
Safety Information
MSDS Information
2-Methyl-3-((2S)-pyrrolidin-2-ylmethoxy)pyridine Usage And Synthesis
UsesPozanicline (ABT-089) selectively activate neuronal nicotinic acetylcholine receptor (nAChR) subtypes, is a novel cholinergic agent that is a partial agonist at α4β2* nAChRs (Ki=16 nM) and shows high selectivity for α6β2* and α4α5β2 nAChR subtypes, the binding affinity (Ki, rat) for Pozanicline to [3H] cytisine sites is 16.7 nM. Pozanicline reverses nicotine withdrawal-induced cognitive deficits, may be an effective component of novel therapeutic strategies for nicotine addiction[1].
References[1] Sullivan JP, et al. ABT-089 [2-methyl-3-(2-(S)-pyrrolidinylmethoxy)pyridine]: I. A potent and selective cholinergic channel modulator with neuroprotective properties. J Pharmacol Exp Ther. 1997 Oct;283(1):235-46. PMID:9336329
[2] Yildirim E, et al. ABT-089, but not ABT-107, ameliorates nicotine withdrawal-induced cognitive deficits in C57BL6/J mice. Behav Pharmacol. 2015 Apr;26(3):241-8. DOI:10.1097/FBP.0000000000000111
2-Methyl-3-((2S)-pyrrolidin-2-ylmethoxy)pyridine Preparation Products And Raw materials
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