2-Fluoro-6-nitrobenzaldehyde
- CAS No.
- 1644-82-2
- Chemical Name:
- 2-Fluoro-6-nitrobenzaldehyde
- Synonyms
- 2-FLUORO-6-NITROBENZAL;2-fluro-6-nitrobenzaldehyde;2-Fluoro-6-nitrobenzaldehyde;3-Fluoro-2-formylnitrobenzene;BENZALDEHYDE,2-FLUORO-6-NITRO-;5-(Trifluoromethyl)acetophenone;2-Fluoro-6-nitrobenzaldehyde99%;2-Fluoro-6-nitrobenzaldehyde 99%
- CBNumber:
- CB71484673
- Molecular Formula:
- C7H4FNO3
- Molecular Weight:
- 169.11
- MDL Number:
- MFCD09835320
- MOL File:
- 1644-82-2.mol
- MSDS File:
- SDS
| Melting point | 62-63℃ |
|---|---|
| Boiling point | 287℃ |
| Density | 1.443 |
| Flash point | 127℃ |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| form | crystalline needles |
| color | Light brown |
| InChI | InChI=1S/C7H4FNO3/c8-6-2-1-3-7(9(11)12)5(6)4-10/h1-4H |
| InChIKey | LMTKLMMRJDNPFT-UHFFFAOYSA-N |
| SMILES | C(=O)C1=C([N+]([O-])=O)C=CC=C1F |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H332-H335 |
| Precautionary statements | P261-P280-P305+P351+P338 |
| HS Code | 2913000090 |
2-Fluoro-6-nitrobenzaldehyde price More Price(46)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biosynth | FF67539 | 2-Fluoro-6-nitrobenzaldehyde | 1644-82-2 | 5g | $219.9 | 2026-06-04 | Buy |
| Biosynth | FF67539 | 2-Fluoro-6-nitrobenzaldehyde | 1644-82-2 | 10g | $392.7 | 2026-06-04 | Buy |
| Biosynth | FF67539 | 2-Fluoro-6-nitrobenzaldehyde | 1644-82-2 | 25g | $785.25 | 2026-06-04 | Buy |
| Biosynth | FF67539 | 2-Fluoro-6-nitrobenzaldehyde | 1644-82-2 | 50g | $1635.5 | 2026-06-04 | Buy |
| Apolloscientific | PC5841 | 2-Fluoro-6-nitrobenzaldehyde 99% | 1644-82-2 | 1g | $32 | 2026-06-04 | Buy |
2-Fluoro-6-nitrobenzaldehyde Chemical Properties, Uses, Production
Uses
2-Fluoro-6-nitrobenzaldehyde is a benzaldehyde analogue with a benzene ring structure containing substitutable groups fluorine and nitro. It can be used as an electron donor to reduce a range of electron acceptors including piperazine. Studies have shown that 2-Fluoro-6-nitrobenzaldehyde has antitumour effects, inhibiting the growth of cancer cells both in vivo and in vitro, and is a potential antipancreatic cancer drug.
Synthesis
769-10-8
4637-24-5
1644-82-2
General procedure for the synthesis of 2-fluoro-6-nitrobenzaldehyde from 2-fluoro-6-nitrotoluene and N,N-dimethylformamide dimethyl acetal: A mixture of 2-fluoro-6-nitrotoluene and N,N-dimethylformamide dimethyl acetal (2.75 eq.) was heated to 135 °C and kept for 12 hours. Upon completion of the reaction, the reaction mixture was cooled to room temperature and slowly added dropwise to a pre-prepared water/DMF (1:1, 1.1 M) solution of NaIO4 (2.75 equiv.). After the dropwise addition, the reaction mixture was stirred at room temperature for 3 hours. Subsequently, the reaction mixture was filtered and the solid was washed with toluene. The filtrate was transferred to a partition funnel to separate the organic and aqueous layers. The organic layer was washed with water and dried with anhydrous Na2SO4. The solvent was removed by evaporation under reduced pressure to give the crude product. The crude product was purified by rapid chromatography on silica gel with gradient elution using EtOAc/petroleum ether (1:30) as eluent to finally obtain 2-fluoro-6-nitrobenzaldehyde in 23% yield. Mass spectrometry analysis (ES+): the theoretical value of C7H4FNO3 was 169 and the measured value was 170 (M+H)+.
References
[1] Patent: WO2010/13037, 2010, A1. Location in patent: Page/Page column 62
2-Fluoro-6-nitrobenzaldehyde Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| https://www.shachemlin.cn/ | 68080707 15021879576 | ming-jiao.wu@chemlin.com.cn | China | 9062 | 58 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Shanghai Harvest Chemical Industrial Co., Ltd. | 15721252604 17321035817 | sales@harvest-chem.com | China | 2829 | 64 |
| Nanjing Chemlin Chemical Co., Ltd | 025-83697070 13770331960 | info@chemlin.com.cn | China | 16305 | 64 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| Shanghai Sunway Pharmaceutical Technology Co., Ltd | 13761987713 | hxzheng@sunwaypharm.cn | China | 8663 | 57 |
| Chengdu Forest Science and Technology Development Co., Ltd. | 18030648795 18030648795 | sales@cdforestchem.com | China | 1996 | 58 |
| Shanghai Litong Chemical Technology Co.,Ltd. | 13598610367 0373-7129549 | 2468833170@qq.com | China | 932 | 58 |
| Shanghai Topbiochem Technology Co., Ltd | +86-21-60341587 | sales@topbiochem.com | China | 6166 | 58 |
| 9ding chemical ( Shanghai) Limited | 4009209199 | sales@9dingchem.com | China | 18201 | 56 |
View Latest Price from 2-Fluoro-6-nitrobenzaldehyde manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2019-07-14 | 2-FLUORO-6-NITROBENZALDEHYDE
1644-82-2
|
$1.00 | 1KG | 99% | 100kg | Career Henan Chemical Co |
-
- 2-FLUORO-6-NITROBENZALDEHYDE
1644-82-2
- $1.00
- 99%
- Career Henan Chemical Co
