Methyl 4-bromothiophene-2-carboxylate
- CAS No.
- 62224-16-2
- Chemical Name:
- Methyl 4-bromothiophene-2-carboxylate
- Synonyms
- methyl 4-chlorothiophene-2-carboxylate;Methyl 4-broMothiophene-2...;4-broMothiophene-2-carboxylate;methyl 4-chlorothiophene-2-carbo;4-Bromo-2-(carbomethoxy)thiophene;Methyl 4-bromothiophen-2-carboxylate;Methyl 4-bromothiophene-2-carboxylate;Methyl 4-bromothiophene-2-carboxylate 98%;4-bromothiophene-2-carboxylic acid methyl ester;4-Bromo-2-thiophenecarboxylic acid methyl ester
- CBNumber:
- CB71504012
- Molecular Formula:
- C6H5BrO2S
- Molecular Weight:
- 221.07
- MDL Number:
- MFCD06203668
- MOL File:
- 62224-16-2.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P302+P352-P305+P351+P338-P362+P364 |
| HS Code | 2934999090 |
Methyl 4-bromothiophene-2-carboxylate price More Price(48)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Apolloscientific | OR17259 | Methyl 4-bromothiophene-2-carboxylate 98% | 62224-16-2 | 10g | $40 | 2026-06-04 | Buy |
| Activate Scientific | AS18031 | Methyl 4-bromothiophene-2-carboxylate 98% | 62224-16-2 | 5g | $26 | 2026-06-04 | Buy |
| Activate Scientific | AS18031 | Methyl 4-bromothiophene-2-carboxylate 98% | 62224-16-2 | 25g | $69 | 2026-06-04 | Buy |
| Activate Scientific | AS18031 | Methyl 4-bromothiophene-2-carboxylate 98% | 62224-16-2 | 100g | $197 | 2026-06-04 | Buy |
| Synthonix | M7697 | Methyl 4-bromothiophene-2-carboxylate 97.0% | 62224-16-2 | 1g | $14 | 2026-05-06 | Buy |
Methyl 4-bromothiophene-2-carboxylate Chemical Properties,Uses,Production
Synthesis
16694-18-1
62224-16-2
b) General procedure for the synthesis of methyl 4-bromothiophene-2-carboxylate: 6.02 g (29.1 mmol) of 4-bromothiophene-2-carboxylic acid (prepared as in the previous procedure) was dissolved in 100 mL of anhydrous methanol under nitrogen protection and cooled to -20 °C. The reaction was completed by the addition of 2.55 mL (34.9 mmol) of thionyl chloride. 2.55 mL (34.9 mmol) of thionyl chloride was slowly added dropwise at a controlled acceleration rate to maintain the reaction temperature below -5 °C (dropwise addition was completed in about 8-10 min). After completion of the dropwise addition, the reaction mixture was stirred at room temperature for 1 hour, followed by refluxing for 8 hours. Upon completion of the reaction, the mixture was cooled and concentrated in vacuum. The resulting 6.7 g of light amber oily product was purified by passing through a 150 g silica gel column, eluting with about 600 mL of dichloromethane (discarding the first 120 mL of the eluate which contained small amounts of impurities). Vacuum concentration gave the title compound, methyl 4-bromothiophene-2-carboxylate, as a colorless oil (6.11 g, 95% yield).1H-NMR (300 MHz, CDCl3) δ 7.69 (d, 1H, J = 1.5 Hz), 7.45 (d, 1H, J = 1.5 Hz), 3.90 (s, 3H).
References
[1] Patent: US2004/72871, 2004, A1. Location in patent: Page/Page column 29
[2] Patent: US2002/37915, 2002, A1
[3] Patent: US6291514, 2001, B1
[4] Patent: US2004/9995, 2004, A1
[5] Archiv der Pharmazie, 1998, vol. 331, # 12, p. 405 - 411
Methyl 4-bromothiophene-2-carboxylate Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Heze Bona Medical Technology Co., LTD | 15865805009 | 15865805009@139.com | China | 2995 | 58 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Adamas Reagent, Ltd. | 400-6009262 15618770481 | yhx@titansci.com | China | 14098 | 59 |
| Accela ChemBio Co.,Ltd. | 021-50795510 4000665055 | marketing@accelachem.com | China | 10972 | 64 |
| Nanjing Chemlin Chemical Co., Ltd | 025-83697070 13770331960 | info@chemlin.com.cn | China | 16305 | 64 |
| Shanghai Ennopharm Co., Ltd. | +86 (21) 6435-5022 | China | 4263 | 65 | |
| Hangzhou Sage Chemical Co., Ltd. | +86057186818502 13588463833 | info@sagechem.com | China | 10265 | 58 |
| Baiyin Chengze Chemical Technology Co., Ltd. | +86 943-8535351 13389336721 | sales@chengzechem.com | China | 300 | 58 |
| Nanjing Norris-Pharm Technology Co., Ltd | 13901585132 | sales@norris-pharm.com | China | 8869 | 55 |
View Lastest Price from Methyl 4-bromothiophene-2-carboxylate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-06-30 | Methyl 4-bromothiophene-2-carboxylate
62224-16-2
|
1kg | 99% | 10000KGS | Shaanxi Dideu New Materials Co. Ltd | ||
 |
2019-12-26 | Methyl 4-bromothiophene-2-carboxylate
62224-16-2
|
$1.00 | 1KG | 99% | 1000KGS | Career Henan Chemical Co |
-
- Methyl 4-bromothiophene-2-carboxylate
62224-16-2
- $0.00
- 99%
- Shaanxi Dideu New Materials Co. Ltd
-
- Methyl 4-bromothiophene-2-carboxylate
62224-16-2
- $1.00
- 99%
- Career Henan Chemical Co
