2-bromo-5-cyanobenzoic acid
- CAS No.
- 845616-12-8
- Chemical Name:
- 2-bromo-5-cyanobenzoic acid
- Synonyms
- 2-bromo-5-cyanobenzoic acid;2-bromo-5-cyanobenozic acid;BENZOIC ACID, 2-BROMO-5-CYANO-
- CBNumber:
- CB71557735
- Molecular Formula:
- C8H4BrNO2
- Molecular Weight:
- 226.03
- MDL Number:
- MFCD11847005
- MOL File:
- 845616-12-8.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| HS Code | 2916399090 |
2-bromo-5-cyanobenzoic acid price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biosynth | VIB61612 | 2-Bromo-5-cyanobenzoic acid | 845616-12-8 | 0.5g | $365.8 | 2026-06-05 | Buy |
| Biosynth | VIB61612 | 2-Bromo-5-cyanobenzoic acid | 845616-12-8 | 5g | $1357 | 2026-06-05 | Buy |
| Apolloscientific | OR400316 | 2-Bromo-5-cyanobenzoic acid ≥95% | 845616-12-8 | 100mg | $41 | 2026-06-04 | Buy |
| Apolloscientific | OR400316 | 2-Bromo-5-cyanobenzoic acid ≥95% | 845616-12-8 | 250mg | $82 | 2026-06-04 | Buy |
| Activate Scientific | AS41929 | 2-Bromo-5-cyanobenzoic acid 97% | 845616-12-8 | 1g | $203 | 2026-06-04 | Buy |
2-bromo-5-cyanobenzoic acid Chemical Properties, Uses, Production
Synthesis
99767-45-0
845616-12-8
The general procedure for the synthesis of 2-bromo-5-cyanobenzoic acid from 2-amino-5-cyanobenzoic acid was as follows: tert-butyl nitrite (1.15 ml, 8.63 mmol) was added dropwise over 2 min at 0 °C to a suspension of copper (II) bromide (1.6 g, 7.1 mmol) in acetonitrile (30 ml). Subsequently, 2-amino-5-cyanobenzoic acid (1.0 g, 6.17 mmol) was added in batches over 10 min at 0 °C. The reaction mixture was stirred at 0 °C for 2 h, then brought to room temperature and stirred overnight. After completion of the reaction, half of the solvent was evaporated under reduced pressure. The residue was dissolved in a mixture of 1N HCl (15 ml) and ethyl acetate (30 ml). The organic layer was extracted with 1N NaOH (3 x 10 ml). The aqueous layer was acidified with 2N HCl and a solid was precipitated. The solid was collected by filtration, washed with water and dried under high vacuum at 50°C to give 2-bromo-5-cyanobenzoic acid (0.92 g, 66% yield) as a yellow solid.
References
[1] Patent: WO2005/23260, 2005, A1. Location in patent: Page/Page column 48
[2] Patent: US2005/209241, 2005, A1. Location in patent: Page/Page column 20
2-bromo-5-cyanobenzoic acid Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| shanghai aokchem co., ltd | 021-68712331 39130253 | aokchem@gmail.com | China | 332 | 58 |
| ShangHai AmK Pharmaceutical Technology Co., Ltd. | 微信 18019252918 18019252918 | sale@amkchem.com | China | 14982 | 55 |
| Shanghai HuanChuan Industry Co.,Ltd. | 021-61478794 | sales@hcshhai.com | China | 9781 | 50 |
| Cool Pharm, Ltd | 021-60455363 18019463053 | sales@coolpharm.com | China | 8455 | 58 |
| Changzhou Anxuan Chemical, Co., Ltd. | 13912302692 | sales@anxuanchem.com | China | 4824 | 58 |
| Shanghai Sainty Biotechnology Co., Ltd. | 021-58957915 17721108391 | 907522080@qq.com | China | 997 | 55 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131885 | 58 |
| Dezhou LonWel Pharmaceutical Technology Co., Ltd. | 13761310616 | 39324283@qq.com | China | 1359 | 58 |
| Wuxi AppTec | 022-59987777 13552403979 | jia_guoqiang@wuxiapptec.com | China | 22344 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29626 | 60 |
