2-Amino-5-cyanobenzoic acid
- CAS No.
- 99767-45-0
- Chemical Name:
- 2-Amino-5-cyanobenzoic acid
- Synonyms
- 2-aMino-5-cyanobenzoic acid;Benzoic acid, 2-amino-5-cyano-;2-Amino-5-cyanobenzoic acid≥ 97% (HPLC)
- CBNumber:
- CB92638486
- Molecular Formula:
- C8H6N2O2
- Molecular Weight:
- 162.15
- MDL Number:
- MFCD20485816
- MOL File:
- 99767-45-0.mol
- MSDS File:
- SDS
- TDS File:
- TDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302+H312+H332-H315-H319-H335 |
| Precautionary statements | P271-P260-P280 |
| RIDADR | 2811 |
| HazardClass | 6.1 |
| PackingGroup | Ⅲ |
| HS Code | 2916399090 |
2-Amino-5-cyanobenzoic acid price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Activate Scientific | AS41928 | 2-Amino-5-cyanobenzoic acid 97% | 99767-45-0 | 1g | $100 | 2026-06-04 | Buy |
| Activate Scientific | AS41928 | 2-Amino-5-cyanobenzoic acid 97% | 99767-45-0 | 5g | $378 | 2026-06-04 | Buy |
| Apolloscientific | OR400360 | 2-Amino-5-cyanobenzoic acid 95% | 99767-45-0 | 1g | $109 | 2026-06-04 | Buy |
| Activate Scientific | AS41928 | 2-Amino-5-cyanobenzoic acid 97% | 99767-45-0 | 25g | $1181 | 2026-06-04 | Buy |
| Apolloscientific | OR400360 | 2-Amino-5-cyanobenzoic acid 95% | 99767-45-0 | 5g | $417 | 2026-06-04 | Buy |
2-Amino-5-cyanobenzoic acid Chemical Properties, Uses, Production
Chemical Properties
Pale yellow solid
Synthesis
159847-81-1
99767-45-0
General procedure for the synthesis of 2-amino-5-cyanobenzoic acid from methyl 2-amino-5-cyanobenzoate: to a methanolic (200 mL) suspension of methyl 2-amino-5-cyanobenzoate (9.55 g, 54.2 mmol) was added an aqueous sodium hydroxide solution (30 mL, 6.0 M, 180 mmol). The reaction mixture was stirred at room temperature and a homogeneous solution was formed after 1 hour. After 27.5 hours of reaction, the solvent was removed by evaporation under reduced pressure and the residue was dissolved in water (300 mL). The resulting aqueous phase was washed with dichloromethane (2 x 200 mL) and subsequently acidified to acidity with concentrated hydrochloric acid (1 L). The product was extracted with ethyl acetate (500 mL), the organic phases were combined and dried over anhydrous magnesium sulfate. The organic phase was concentrated under reduced pressure to give 8.57 g (97.5% yield) of yellow solid product, which could be used in subsequent reactions without further purification.
References
[1] Patent: WO2004/18428, 2004, A1. Location in patent: Page 347
[2] Patent: WO2014/93869, 2014, A1. Location in patent: Paragraph 0140
[3] Journal of Medicinal Chemistry, 2014, vol. 57, # 20, p. 8608 - 8621
[4] Patent: WO2004/18428, 2004, A1. Location in patent: Page 370
[5] Patent: WO2004/18414, 2004, A2. Location in patent: Page 136
2-Amino-5-cyanobenzoic acid Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| SpringPharma Tech Co.,Ltd | +86-25-68710855, +86-25-68710897 | sales@springpharma.net | China | 1260 | 62 |
| Shanghai Topbiochem Technology Co., Ltd | 021-58170097 | info@topbiochem.com | China | 9509 | 58 |
| Shanghai T&W Pharmaceutical Co., Ltd. | +86 21 61551611 | China | 9874 | 58 | |
| Shanghai Keepontech Co.,Ltd | 021-54849683 13601642561 | sales@keepontech.com | China | 998 | 59 |
| Shanghai Aladdin Bio-Chem Technology Co.,LTD | 400-6206333 13167063860 | anhua.mao@aladdin-e.com | China | 29977 | 65 |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
| Suzhou Lakestar Pharmatech Co., Ltd. | 0512-63970158-603 18018108880 | info@lakestarpharma.com | China | 401 | 59 |
| Changzhou Anxuan Chemical, Co., Ltd. | 13912302692 | sales@anxuanchem.com | China | 4824 | 58 |
| Shanghai Haozhixiang Biotechnology Co., Ltd | 526763801 13301653310 | 526763801@qq.com | China | 7983 | 55 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
