5-Amino-2-bromobenzoic acid
- CAS No.
- 2840-02-0
- Chemical Name:
- 5-Amino-2-bromobenzoic acid
- Synonyms
- 5-AMINO-2-BROMOBENZOIC;4-Bromo-3-carboxyaniline;2-Bromo-5-aminobenzoic acid;5-Amino-2-bromobenzoic acid;Benzoic acid, 5-amino-2-bromo-;5-Amino-2-bromobenzoic acid 94%;5-AMINO-2-BROMOBENZOIC ACID USP/EP/BP
- CBNumber:
- CB0707330
- Molecular Formula:
- C7H6BrNO2
- Molecular Weight:
- 216.03
- MDL Number:
- MFCD07368968
- MOL File:
- 2840-02-0.mol
- MSDS File:
- SDS
| Melting point | 171-179 °C |
|---|---|
| storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| form | Solid |
| color | Brown |
| Water Solubility | Slightly soluble in water. |
| Major Application | peptide synthesis |
| InChI | InChI=1S/C7H6BrNO2/c8-6-2-1-4(9)3-5(6)7(10)11/h1-3H,9H2,(H,10,11) |
| InChIKey | FEXDUVBQBNYSQV-UHFFFAOYSA-N |
| SMILES | C(O)(=O)C1=CC(N)=CC=C1Br |
| CAS DataBase Reference | 2840-02-0(CAS DataBase Reference) |
| UNSPSC Code | 12352106 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) | ![]() GHS06 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H301-H315-H319-H335 | |||||||||
| Precautionary statements | P301+P310+P330-P302+P352-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Faceshields, Gloves | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 22-36/37/38 | |||||||||
| Safety Statements | 26-36/37 | |||||||||
| RIDADR | UN 2811 6.1/PG 3 | |||||||||
| WGK Germany | 3 | |||||||||
| Hazard Note | Harmful | |||||||||
| HazardClass | 6.1 | |||||||||
| HS Code | 2922498590 | |||||||||
| Storage Class | 6.1C - Combustible acute toxic Cat.3 toxic compounds or compounds which causing chronic effects |
|||||||||
| Hazard Classifications | Acute Tox. 3 Oral Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
|||||||||
| Limited Quantities | 5.0 kg (11 lbs) (solid) | |||||||||
| Excepted Quantities | Max Inner Pack (30g or 30ml) and Max Outer Pack (1Kg or 1L) | |||||||||
| NFPA 704 |
|
5-Amino-2-bromobenzoic acid price More Price(53)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 668036 | 5-Amino-2-bromobenzoic acid 94% | 2840-02-0 | 5g | $84.3 | 2023-06-20 | Buy |
| Sigma-Aldrich | 668036 | 5-Amino-2-bromobenzoic acid 94% | 2840-02-0 | 25g | $359 | 2023-06-20 | Buy |
| TRC | TRC-A602490-5G | 5-Amino-2-bromobenzoic Acid | 2840-02-0 | 5g | $65 | 2026-06-03 | Buy |
| TRC | TRC-A602490-10G | 5-Amino-2-bromobenzoic Acid | 2840-02-0 | 10g | $103 | 2026-06-03 | Buy |
| Biosynth | FA70334 | 5-Amino-2-bromobenzoic acid | 2840-02-0 | 0.1kg | $150 | 2026-06-04 | Buy |
5-Amino-2-bromobenzoic acid Chemical Properties, Uses, Production
Chemical Properties
White crystalline solid
Uses
It is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuffs and is also used in medicine.
Uses
5-Amino-2-bromobenzoic Acid can be used for FABP4 and FABP4 inhibitors to prevent or treat FABP 4/5 related diseases.
reaction suitability
reaction type: solution phase peptide synthesis
Synthesis
99-05-8
2840-02-0
General procedure for the synthesis of 5-amino-2-bromobenzoic acid from 3-aminobenzoic acid: 3-aminobenzoic acid (3.00 g, 21.9 mmol) was dissolved in N,N-dimethylformamide (18.0 mL) and cooled to below 5 °C. In another vessel, a solution was prepared by mixing N,N-dimethylformamide (9.00 mL) with N-bromosuccinimide (4.09 g, 23.0 mmol). This solution was slowly added to the cooled 3-aminobenzoic acid solution, keeping the reaction temperature at 5 °C or lower. The reaction mixture was stirred at 5 °C for 1 h. After the reaction mixture was stirred for 1 h, water (60.0 mL) was added and the stirring was continued for 12 h at 5 °C. Upon completion of the reaction, the solid product was collected by filtration, and the filtrate was washed with water (5.00 mL) and dried to give 5-amino-2-bromobenzoic acid (3.68 g, 78% yield). The structure of the product was confirmed by 1H-NMR (400 MHz, DMSO-D6): δ 5.49 (s, 2H), 6.59 (dd, J = 8.5,2.9Hz, 1H), 6.93 (d, J = 2.9Hz, 1H), 7.25 (d, J = 8.5Hz, 1H), 13.04 (s, 1H).
Purification Methods
Crystallise the acid from H2O or *C6H6 (m 128o). The acetyl derivative crystallises from H2O (as monohydrate) or absolute EtOH with m 196-197o (anhydrous). [Koopal Rec Trav Chim, Pays Bas 34 148 1915, Bamberger Chem Ber 57 2090 1924, Beilstein 14 H 413, 14 II 245.]
References
[1] Patent: US2013/310576, 2013, A1. Location in patent: Paragraph 0151
5-Amino-2-bromobenzoic acid Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| Accela ChemBio Co.,Ltd. | 021-50795510 4000665055 | marketing@accelachem.com | China | 10972 | 64 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| Shandong Xiya Chemical Co., Ltd | 13355009207 13355009207 | 3007715519@qq.com | China | 18722 | 57 |
| Shanghai Sunway Pharmaceutical Technology Co., Ltd | 13761987713 | hxzheng@sunwaypharm.cn | China | 8663 | 57 |
| Shanghai Topbiochem Technology Co., Ltd | +86-21-60341587 | sales@topbiochem.com | China | 6166 | 58 |
View Latest Price from 5-Amino-2-bromobenzoic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2025-06-27 | 5-AMINO-2-BROMOBENZOIC ACID
2840-02-0
|
1KG | 99% | 500000kg | Hebei Chuanghai Biotechnology Co., Ltd | ||
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2025-06-20 | 5-AMINO-2-BROMOBENZOIC ACID
2840-02-0
|
$7.00-30.00 | 1kg | 0.99 | 20 tons | Hebei Yanxi Chemical Co., Ltd. | |
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2021-08-12 | 5-AMINO-2-BROMOBENZOIC ACID
2840-02-0
|
$10.00-15.00 | 1KG | 99%+ HPLC | Zhuozhou Wenxi import and Export Co., Ltd |
-

- 5-AMINO-2-BROMOBENZOIC ACID
2840-02-0
- 99%
- Hebei Chuanghai Biotechnology Co., Ltd
-

- 5-AMINO-2-BROMOBENZOIC ACID
2840-02-0
- $7.00-30.00
- 0.99
- Hebei Yanxi Chemical Co., Ltd.
-

- 5-AMINO-2-BROMOBENZOIC ACID
2840-02-0
- $10.00-15.00
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
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