6-AMIDINO-2-NAPHTHOL METHANESULFONATE
- CAS No.
- 82957-06-0
- Chemical Name:
- 6-AMIDINO-2-NAPHTHOL METHANESULFONATE
- Synonyms
- Nafamostat Impurity(Mesylate);6-Amidino-2-naphthol mesylate;Amidinonaphtolmethanesulfonate;Nafamostat Impurity 7 Mesylate;Nafamostat Impurity 10 Mesylate;Nafamostat Impurity 13 Mesylate;Nafamostat Impurity 16(Mesylate);Nafamostat mesylate Intermediate;6-aMidino-2-naphthol Methansulfonate;6-Amidino-2-naphtol methanesulfonate
- CBNumber:
- CB7158685
- Molecular Formula:
- C12H14N2O4S
- Molecular Weight:
- 282.32
- MDL Number:
- MFCD00143493
- MOL File:
- 82957-06-0.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| 6-Amidino-2-naphthol Methanesulfonate >99.0%(HPLC)(T) | A1193 | 1g | $153 |
| 6-Amidino-2-naphthol Methanesulfonate >99.0%(HPLC)(T) | A1193 | 5g | $446 |
| 6-hydroxynaphthalene-2-carboximidamide methanesulfonic acid 95+% | H56645 | 250mg | $64 |
| 6-hydroxynaphthalene-2-carboximidamide methanesulfonic acid 95+% | H56645 | 1g | $68 |
| 6-hydroxynaphthalene-2-carboximidamide methanesulfonic acid 95+% | H56645 | 5g | $70 |
| More product size | |||
| Melting point | 230 - 233°C |
|---|---|
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| solubility | Acetonitrile (Slightly), DMSO (Slightly) |
| form | Solid |
| color | White to Off-White |
| Stability | Hygroscopic |
| InChI | InChI=1S/C11H10N2O.CH4O3S/c12-11(13)9-2-1-8-6-10(14)4-3-7(8)5-9;1-5(2,3)4/h1-6,14H,(H3,12,13);1H3,(H,2,3,4) |
| InChIKey | NLLGCELWCUFUFD-UHFFFAOYSA-N |
| SMILES | C12C=CC(O)=CC=1C=CC(C(=N)N)=C2.S(=O)(=O)(O)C |
| CAS DataBase Reference | 82957-06-0(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H302 | |||||||||
| Precautionary statements | P264-P280-P305+P351+P338-P337+P313P-P264-P270-P301+P312-P330-P501-P264-P280-P302+P352-P321-P332+P313-P362 | |||||||||
| HS Code | 2922.29.8190 | |||||||||
| NFPA 704 |
|
6-AMIDINO-2-NAPHTHOL METHANESULFONATE price More Price(22)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | A1193 | 6-Amidino-2-naphthol Methanesulfonate >99.0%(HPLC)(T) | 82957-06-0 | 1g | $153 | 2026-04-30 | Buy |
| TCI Chemical | A1193 | 6-Amidino-2-naphthol Methanesulfonate >99.0%(HPLC)(T) | 82957-06-0 | 5g | $446 | 2026-04-30 | Buy |
| Synthonix | H56645 | 6-hydroxynaphthalene-2-carboximidamide methanesulfonic acid 95+% | 82957-06-0 | 250mg | $64 | 2026-05-06 | Buy |
| Synthonix | H56645 | 6-hydroxynaphthalene-2-carboximidamide methanesulfonic acid 95+% | 82957-06-0 | 1g | $68 | 2026-05-06 | Buy |
| Synthonix | H56645 | 6-hydroxynaphthalene-2-carboximidamide methanesulfonic acid 95+% | 82957-06-0 | 5g | $70 | 2026-05-06 | Buy |
6-AMIDINO-2-NAPHTHOL METHANESULFONATE Chemical Properties,Uses,Production
Uses
6-Amidino-2-naphthol Methanesulfonate is a useful N-terminal derivatization reagent for improving peptide fragmentation.
Synthesis
52927-22-7
75-36-5
82957-06-0
1. Add 800 mL of anhydrous ethanol to a dry triple-necked flask, initiate stirring and cool the reaction system to 0-5 °C. 2. 430 mL of acetyl chloride was slowly added dropwise, and the rate of dropwise acceleration was controlled to maintain the reaction temperature at 0-5 °C. 3. 3. after the dropwise addition, keep the reaction system at 0-5°C for a period of time. 4. 85 g of 6-cyano-2-naphthol was added to the reaction system, warmed to 10 °C and kept for 10 hours. 5. After completion of the reaction, methyl tert-butyl ether was added, stirred for 1 hour and filtered. 6. The filter cake was washed with methyl tert-butyl ether, dried and mixed with ethanol. 7. The mixture was heated to 50°C and bubbled with dry ammonia for 3 hours. 8. 8. At the end of the reaction, the solvent was removed by evaporation under reduced pressure to give a yellow solid. 9. The solid was stirred with saturated sodium bicarbonate solution for a period of time, filtered and washed with water to neutral. 10. 10. Suspend the product in methanol and add appropriate amount of methanesulfonic acid solution dropwise. 11. 11. Add methyl tert-butyl ether to precipitate the solid, filter and wash with methyl tert-butyl ether. 12. Recrystallization was carried out with ethanol to give 75 g of a yellow solid product with a melting point of 227-230 °C and a yield of 53%.
References
[1] Patent: CN103896809, 2017, B. Location in patent: Paragraph 0010; 0011; 0012; 0013
6-AMIDINO-2-NAPHTHOL METHANESULFONATE Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 20124 | 58 |
| Capot Chemical Co.,Ltd. | +8613336195806 | sales@capot.com | China | 29640 | 60 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21588 | 55 |
| Nanjing ChemLin Chemical Industry Co., Ltd. | 025-83697070 | product@chemlin.com.cn | CHINA | 3009 | 60 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29815 | 58 |
| Zhejiang ZETian Fine Chemicals Co. LTD | +8618957127338 | stella@zetchem.com | China | 2994 | 58 |
| Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 | admin@nexconn.com | China | 10404 | 58 |
| HaBo Hong Kong Co., Limited. | +86-25-18512596065 | info@habotech.com | CHINA | 933 | 58 |
| Jinan Finer Chemical Co., Ltd | +86-531-88989536 +86-15508631887 | sales@finerchem.com | China | 2950 | 58 |
View Lastest Price from 6-AMIDINO-2-NAPHTHOL METHANESULFONATE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-05-25 | 6-Amidino-2-naphthol methanesulfonate
82957-06-0
|
US $0.00 / KG | 1KG | 98%min | 30tons/month | WUHAN FORTUNA CHEMICAL CO., LTD | |
 |
2025-11-18 | 6-AMIDINO-2-NAPHTHOL METHANESULFONATE
82957-06-0
|
US $1.10 / g | 1g | 99.0% Min | 100 Tons | Dideu Industries Group Limited | |
 |
2025-09-25 | 6-AMIDINO-2-NAPHTHOL METHANESULFONATE
82957-06-0
|
US $35.00-1.40 / kg | 1kg | 99% | g-kg-tons, free sample is available | Henan Fengda Chemical Co., Ltd |
-
- 6-Amidino-2-naphthol methanesulfonate
82957-06-0
- US $0.00 / KG
- 98%min
- WUHAN FORTUNA CHEMICAL CO., LTD
-
- 6-AMIDINO-2-NAPHTHOL METHANESULFONATE
82957-06-0
- US $1.10 / g
- 99.0% Min
- Dideu Industries Group Limited
-
- 6-AMIDINO-2-NAPHTHOL METHANESULFONATE
82957-06-0
- US $35.00-1.40 / kg
- 99%
- Henan Fengda Chemical Co., Ltd
