3-acetyl-4-hydroxybenzoic acid
- CAS No.
- 16357-40-7
- Chemical Name:
- 3-acetyl-4-hydroxybenzoic acid
- Synonyms
- Propanoicacid,6-ethoxy-;4-Hydroxy-3-acetylbenzoicacid;3-acetyl-4-hydroxybenzoic acid;5-Carboxy-2-hydroxyacetophenone;5'-Carboxy-2'-hydroxyacetophenone;Benzoic acid, 3-acetyl-4-hydroxy-;2'-Hydroxyacetophenone-5'-carboxylic acid
- CBNumber:
- CB71720144
- Molecular Formula:
- C9H8O4
- Molecular Weight:
- 180.16
- MDL Number:
- MFCD00532680
- MOL File:
- 16357-40-7.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| 3-Acetyl-4-hydroxybenzoic acid ≥97% | CS-0102036 | 1g | $18 |
| 3-Acetyl-4-hydroxybenzoic acid ≥97% | CS-0102036 | 5g | $66 |
| 3-Acetyl-4-hydroxybenzoic acid ≥97% | CS-0102036 | 10g | $126 |
| 3-Acetyl-4-hydroxybenzoic acid ≥97% | CS-0102036 | 25g | $301 |
| 3-Acetyl-4-hydroxybenzoic acid ≥97% | CS-0102036 | 100g | $1087 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
3-acetyl-4-hydroxybenzoic acid price More Price(42)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-0102036 | 3-Acetyl-4-hydroxybenzoic acid ≥97% | 16357-40-7 | 1g | $18 | 2026-06-04 | Buy |
| ChemScene | CS-0102036 | 3-Acetyl-4-hydroxybenzoic acid ≥97% | 16357-40-7 | 5g | $66 | 2026-06-04 | Buy |
| ChemScene | CS-0102036 | 3-Acetyl-4-hydroxybenzoic acid ≥97% | 16357-40-7 | 10g | $126 | 2026-06-04 | Buy |
| ChemScene | CS-0102036 | 3-Acetyl-4-hydroxybenzoic acid ≥97% | 16357-40-7 | 25g | $301 | 2026-06-04 | Buy |
| ChemScene | CS-0102036 | 3-Acetyl-4-hydroxybenzoic acid ≥97% | 16357-40-7 | 100g | $1087 | 2026-06-04 | Buy |
3-acetyl-4-hydroxybenzoic acid Chemical Properties,Uses,Production
Uses
3-Acetyl-4-hydroxybenzoic Acid can be used in methods to treat epilepsy.
Preparation
Obtained by Fries rearrangement of 4-acetoxybenzoic acid (1 mol) with aluminium chloride (3.3 mol) at 150–155° for 1 h (24%).
Synthesis
13031-45-3
16357-40-7
4.3 Synthesis of 3-acetyl-4-hydroxybenzoic acid: magnesium perchlorate (Mg(ClO4)2, 0.602 mmol, 0.134 g, 2 mol%) was added to a solution of ethyl 4-hydroxybenzoate (30.1 mmol, 5 g) in acetic anhydride (Ac2O, 45.15 mmol, 4.25 mL) and the reaction mixture was stirred at room temperature overnight. Upon completion of the reaction, the reaction solution was diluted with dichloromethane (DCM) and subsequently washed with water. The organic phase was dried with anhydrous magnesium sulfate (MgSO4) and concentrated under reduced pressure to remove the solvent to give a clarified oil. The oil was azeotropized twice with toluene to remove residual water to give a clear oily intermediate (5.73 g, 92% yield). Subsequently, the intermediate was mixed with aluminum trichloride (AlCl3, 82.5 mmol, 10.99 g, 3 eq.) and potassium chloride (KCl, 28.9 mmol, 2.15 g, 1.05 eq.) and heated to react at 150 °C for 1.5 h. Dark-colored foam was formed during the reaction. At the end of the reaction, the reaction mixture was cooled in an ice bath and pre-cooled aqueous 2M hydrochloric acid solution (100 mL) was slowly added. After stirring for 5 minutes, ethanol (20 mL) was added and the mixture was heated to reflux for 45 minutes. Upon completion of the reaction, the mixture was again cooled in an ice bath and the precipitated solid was collected by filtration. Finally, the target product, 3-acetyl-4-hydroxybenzoic acid, was purified by solvent recrystallization from tetrahydrofuran (THF)/ethanol (EtOH) mixture to give the target product, 3-acetyl-4-hydroxybenzoic acid, as a cream-colored solid (1.30 g, 26% yield).
References
[1] Patent: WO2006/64286, 2006, A1. Location in patent: Page/Page column 93
[2] Patent: WO2007/144379, 2007, A1. Location in patent: Page/Page column 38-39
[3] Journal of Medicinal Chemistry, 1980, vol. 23, # 3, p. 335 - 338
3-acetyl-4-hydroxybenzoic acid Preparation Products And Raw materials
Raw materials
Preparation Products
3-acetyl-4-hydroxybenzoic acid Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 | admin@nexconn.com | China | 10399 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 +86-13203830695 | laboratory@coreychem.com | China | 30203 | 58 |
| ANHUI WITOP BIOTECH CO., LTD | +8618071025641 | eric@witopchemical.com | China | 23504 | 58 |
| Labnetwork lnc. | +86-27-50766799 +86-18062016861 | contact@labnetwork.com | China | 19981 | 58 |
| Henan Aochuang Chemical Co.,Ltd. | +86-0371-63689365 +8618638391208 | sales@aochuangchem.com | China | 9322 | 58 |
| Xuzhou B&C Chemical Technology Co., Ltd | +86-400-0516-021 +86-15190678838 | info@bcpharma.com | China | 2728 | 58 |
| Sichuan Biosynce Pharmatech Co., Ltd. | diane@biosynce.com | China | 4863 | 58 | |
| Aladdin Scientific | tp@aladdinsci.com | United States | 50108 | 58 | |
| Suzhou ARTK Medchem Co., Ltd. | +86-18168183658 | sales1@artkmedchem.com | China | 39007 | 58 |
| Shanghai Likang New Materials Co., Limited | +86-16631818819 +86-17736933208 | 3684455296@qq.com | China | 9285 | 58 |
View Lastest Price from 3-acetyl-4-hydroxybenzoic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-04-04 | 3-Acetyl-4-hydroxybenzoic acid
16357-40-7
|
1KG | 98% | 1Ton | Henan Aochuang Chemical Co.,Ltd. |
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- 3-Acetyl-4-hydroxybenzoic acid
16357-40-7
- 98%
- Henan Aochuang Chemical Co.,Ltd.
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