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4,4-Diethoxy-N,N-dimethyl-1-butanamine

4,4-Diethoxy-N,N-dimethyl-1-butanamine structure

CAS No.: 1116-77-4

Chemical Name:: 4,4-Diethoxy-N,N-dimethyl-1-butanamine

Synonyms: 4,4-diethoxy-N,N-diMethylbutan-1-aMine;Zolmitriptan USP RC H;1-Butanamine,4,4-diethoxy-N,N-;Zolmitriptan Related Compound H;4,4-Diethoxy-N-Dimethylbutylamine;(4,4-DIETHOXY-BUTYL)-DIMETHYL-AMINE;4,4-DIETHOXY-N,N-DIMETHYLBUTANAMINE;Zolmitriptan USP Related Compound H;4-DiMethylaMinobutanol diethylacetal;4,4-DIETHOXY-N, N-DIMETHYL-BUTYLAMINE

CBNumber:: CB7176364

Molecular Formula:: C10H23NO2

Molecular Weight:: 189.3

MDL Number:: MFCD00671479

MOL File:: 1116-77-4.mol

MSDS File:: SDS

Last updated:2025-07-24 18:13:42

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4,4-Diethoxy-N,N-dimethyl-1-butanamine Properties

Boiling point	194-195C
Density	0.844 g/mL at 25 °C(lit.)
refractive index	n20/D 1.421(lit.)
Flash point	158 °F
storage temp.	2-8°C
solubility	Chloroform, Ethyl Acetate
form	Oil
pka	9.71±0.28(Predicted)
color	Colourless to Pale Yellow
InChI	InChI=1S/C10H23NO2/c1-5-12-10(13-6-2)8-7-9-11(3)4/h10H,5-9H2,1-4H3
InChIKey	QKXMWBLNSPNBEY-UHFFFAOYSA-N
SMILES	C(N(C)C)CCC(OCC)OCC
CAS DataBase Reference	1116-77-4(CAS DataBase Reference)
FDA UNII	P64QEI4T0I
UNSPSC Code	41116107
NACRES	NA.24

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS05

Signal word

Danger

Hazard statements

H318

Precautionary statements

P280-P305+P351+P338+P310

Hazard Codes

Xi,C

Risk Statements

41-34-10-36/37/38

Safety Statements

26-36/37/39-16-37

RIDADR

UN 3267 8 / PGIII

WGK Germany

HS Code

29225090

NFPA 704

	1
2		0

4,4-Diethoxy-N,N-dimethyl-1-butanamine price More Price(21)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	647055	4,4-Diethoxy-N,N-dimethyl-1-butanamine	1116-77-4	5g	$79.1	2025-07-31	Buy
Sigma-Aldrich	1727097	Zolmitriptan Related Compound H United States Pharmacopeia (USP) Reference Standard	1116-77-4	50mg	$1360	2025-07-31	Buy
TCI Chemical	D3973	4-(Dimethylamino)butyraldehyde Diethyl Acetal >98.0%(GC)(T)	1116-77-4	5g	$32	2025-07-31	Buy
TCI Chemical	D3973	4-(Dimethylamino)butyraldehyde Diethyl Acetal >98.0%(GC)(T)	1116-77-4	25g	$87	2025-07-31	Buy
Sigma-Aldrich	647055	4,4-Diethoxy-N,N-dimethyl-1-butanamine	1116-77-4	25g	$500	2025-07-31	Buy

Product number	Packaging	Price	Buy
647055	5g	$79.1	Buy
1727097	50mg	$1360	Buy
D3973	5g	$32	Buy
D3973	25g	$87	Buy
647055	25g	$500	Buy

4,4-Diethoxy-N,N-dimethyl-1-butanamine Chemical Properties,Uses,Production

Chemical Properties

Light yellow liquid

Uses

4,4-Diethoxy-N,N-dimethyl-1-butanamine is used in organic synthesis and pharmaceutical intermediates, it is an intermediate for Sumatriptan, Rizatriptan, Almotriptan, Zolmitriptan.

Application

4-Dimethylaminobutyraldehyde Diethyl Acetal (Zolmitriptan USP Related Compound H) is used in the preparation of N,N-Dimethyltryptamines, 5-HT1D receptor agonists, for medicinal treatments such as antimigraine drugs.

Preparation

4-Dimethylaminobutyraldehyde diethyl acetal synthesis: The reaction of 1-bromo-3-chloro propane and dimethylamine solution with PEG as a phase transfer catalyst, and obtained 3-dimethylamino-1-chloro propane. 3-dimethylamino-1-chloro propane reacted with magnesium and Grinard reagent was acquired. 4-Dimethylaminobutyraldehyde diethyl acetal is obtained by the reaction of Grinard reagent and triethyl orthoformate. The yield was 70.11%.

Synthesis Reference(s)

Tetrahedron Letters, 35, p. 2401, 1994 DOI: 10.1016/0040-4039(94)85230-8

Synthesis

109-54-6

122-51-0

1116-77-4

Magnesium shavings (25 g) were added to a 2L four-necked round-bottomed flask under nitrogen protection. Benzene (50 mL), benzene solution of 3-chloro-1-(N,N-dimethyl)propylamine (50 mL), triethyl orthoformate (20 g), and a small amount of iodine crystals were added sequentially and slowly heated to reflux temperature. After 15-20 minutes of refluxing, a vigorous reaction was observed, indicating the onset of the Grignard reaction. The remaining benzene solution of 3-chloro-1-(N,N-dimethyl)propylamine and triethyl orthoformate (174 g, where R3 = R5 = Et) were loaded into two charging funnels and added slowly and dropwise to the reaction mixture over a period of 3-4 hr, maintaining reflux. After completion of the reaction, it was cooled to 25 °C and filtered through a diatomaceous earth pad. The filter cake was washed with benzene (100 mL). Benzene was removed by distillation at atmospheric pressure using a 20 cm Vigreux column. The residue was distilled under mild vacuum with a controlled bath temperature below 100 °C to recover excess triethyl orthoformate (60 g). Finally, 4-dimethylaminobutyraldehyde diethyl acetal was purified by reduced pressure distillation to give 125 g (75.8% yield) of a colorless liquid with a boiling point of 140-150°C/15-20 mmHg.

References

[1] Patent: WO2003/101931, 2003, A2. Location in patent: Page 14-15
[2] Patent: WO2003/101931, 2003, A2. Location in patent: Page 15-16
[3] Patent: WO2004/99141, 2004, A1. Location in patent: Page 9-10

4,4-Diethoxy-N,N-dimethyl-1-butanamine synthesis

Synthesis of 4,4-Diethoxy-N,N-dimethyl-1-butanamine from 3-Chloro-1-(N,N-dimethyl)propylamine and Triethyl orthoformate

4,4-Diethoxy-N,N-dimethyl-1-butanamine Preparation Products And Raw materials

Raw materials

4,4-Diethoxybutylamine DIETHYL PHENYL ORTHOFORMATE 3-Chloro-1-(N,N-dimethyl)propylamine Ethanol Triethyl orthoformate

iodine CHLORO[3-(DIMETHYLAMINO)PROPYL]MAGNESIUM Benzene Formaldehyde Magnesium

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Preparation Products

4,4-Diethoxy-N,N-dimethyl-1-butanamine Suppliers

Global( 320)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Fluoropharm Co., Ltd.	+86-0571-85586753 +86-13336034509	sales@fluoropharm.com	China	1445	60
Shaanxi Dideu Medichem Co. Ltd	+86-29-81148696 +86-15536356810	1022@dideu.com	China	3889	58
Hebei Chuanghai Biotechnology Co,.LTD	+86-13131129325	sales1@chuanghaibio.com	China	5251	58
Henan Bao Enluo International TradeCo.，LTD	+86-17331933971	deasea125996@gmail.com	China	2472	58
Capot Chemical Co.,Ltd.	+8613336195806	sales@capot.com	China	29731	60
Nanjing Gold Pharmaceutical Technology Co. Ltd.	025-84209270 15906146951		CHINA	115	55
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21622	55
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29855	58
Shenzhen Nexconn Pharmatechs Ltd	+86-755-89396905 +86-15013857715	admin@nexconn.com	China	10406	58
Jinan Carbotang Biotech Co.,Ltd.	+8615866703830	figo.gao@foxmail.com	China	8497	58

Supplier	Advantage
Fluoropharm Co., Ltd.	60
Shaanxi Dideu Medichem Co. Ltd	58
Hebei Chuanghai Biotechnology Co,.LTD	58
Henan Bao Enluo International TradeCo.，LTD	58
Capot Chemical Co.,Ltd.	60
Nanjing Gold Pharmaceutical Technology Co. Ltd.	55
Henan Tianfu Chemical Co.,Ltd.	55
career henan chemical co	58
Shenzhen Nexconn Pharmatechs Ltd	58
Jinan Carbotang Biotech Co.,Ltd.	58

View Lastest Price from 4,4-Diethoxy-N,N-dimethyl-1-butanamine manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2025-08-13	4,4-Diethoxy-N,N-dimethyl-1-butanamine 1116-77-4			0.99		RongNa Biotechnology Co.,Ltd
2025-08-08	4,4-Diethoxy-N,N-dimethyl-1-butanamine 1116-77-4	US $100.00 / kg	1kg	99	300tons	Hebei Mujin Biotechnology Co.,Ltd
2025-07-25	4,4-Diethoxy-N,N-dimethyl-1-butanamine 1116-77-4	US $0.00 / kg	1kg	99%	10000KGS	Shaanxi Dideu New Materials Co. Ltd

4,4-Diethoxy-N,N-dimethyl-1-butanamine
1116-77-4
0.99
RongNa Biotechnology Co.,Ltd

4,4-Diethoxy-N,N-dimethyl-1-butanamine
1116-77-4
US $100.00 / kg
99
Hebei Mujin Biotechnology Co.,Ltd

4,4-Diethoxy-N,N-dimethyl-1-butanamine
1116-77-4
US $0.00 / kg
99%
Shaanxi Dideu New Materials Co. Ltd

4,4-Diethoxy-N,N-dimethyl-1-butanamine Spectrum

4,4-Diethoxy-N,N-dimethyl-1-butanamine(1116-77-4)¹HNMR

1116-77-4(4,4-Diethoxy-N,N-dimethyl-1-butanamine)Related Search:

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Dimethyl sulfate Ethylene glycol diethyl ether ETHANE Diethyl oxalate Dimethyl ether

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Acetal Metformin Dimethyl phthalate

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N,N-DIMETHYL-4-AMINOBUTANAL DIETHYL ACETAL N, N-DIMETHYL-4,4-DIETHOXY-1-BUTANAMINE Zolmitriptan Related Compound H 4-(N,N-DIMETHYLAMINO)BUTANAL DIETHYL ACETAL 4-DIMETHYLAMINO BUTYRALDEHYDE DIETHYL ACETAL 4-DIMETHYLAMINO BUTANAL DIETHYL ACETAL (4,4-DIETHOXY-BUTYL)-DIMETHYL-AMINE 4,4-DIETHOXY-N,N-DIMETHYL-1-BUTANAMINE 4,4-DIETHOXY-N,N-DIMETHYLBUTANAMINE 4,4-DIETHOXY-N, N-DIMETHYL-BUTYLAMINE 1-BUTANAMINE 4,4-DIETHOXY-N,N-DIMETHYL 1-Butanamine, 4,4-diethoxy-N,N-dimethyl- S 4,4-Diethoxy-N,N-dimethyl-1-butanamine(DDBA) 1-Butanamine,4,4-diethoxy-N,N- 4,4-diethoxy-N,N-dimethyl-butylamine (intermediate of zolmitriptan and sumatriptan) 4-(N,N-DIMETHYLAMINO)BUTANAL DIETHYL ACETAL(FOR ZOLMITRIPTAN AND OTHER TRIPTANS) 4-(N,N-DIMETHYLAMINO)-BUTYRALDEHYDE DIETHYL ACETAL 4-N,N-DIMETHYLAMINOBUTANAL DIETHYL ACETAL (FOR SUMATRIPTAN, RIZATRIPTAN, ZOLMITRIPTAN) 4-N,N-dimethylaminobutanal diethyl acetal ( For Triptans ) 4,4-DIETHOXY-N,N-DIMETHYL BUTYLAMINE,GC 96+% 4-DimethylamineButyaldehydeDimethylAcetal(ForSumatriptan) 4-Dimethylamine butyaldehyde dimethyl acetal N,N-diethylamino-butyraldehyde diethyl acetal 4,4-Diethoxy-N-Dimethylbutylamine 4-(N,N-Dimethylamino)butyaldehyde diethyl acetal 1-(N,N-Dimethylamino)-4,4-diethoxybutane Zolmitriptan USP RC H 4,4-diethoxy-N,N-diMethylbutan-1-aMine 4,4-Diethoxy-N,N-diMethyl-1-butanaMine, 97.5% 4-DiMethylaMinobutanol diethylacetal 4,4-diethoxy-N,N-dimethyl-1-But·Namine 4,4-Diethoxy-N,N-dimethyl-1-butanamine 1116-77-4 1116-77-4 4,4-Diethoxy-N,N-dimethyl-1-butanamine 4,4-Dimethylaminobutyraldehyde diethylacetal Zolmitriptan USP Related Compound H 4-(Dimethylamino)butyraldehydeDiethylAcetal> Zolmitriptan Impurity 10(Zolmitriptan USP RC H) 4,4-Diethoxy-N,N-dimethyl-1-l-butanamine 4-(N,N-Dimethylamino) butane ditheyl acetal 4-Dimethylaminobutyraldehyde Diethyl Acetal/Zolmitriptan USP RC H 4-Dimethylamino Butanal Diethyl AcetalQ: What is 4-Dimethylamino Butanal Diethyl Acetal Q: What is the CAS Number of 4-Dimethylamino Butanal Diethyl Acetal Q: What is the storage condition of 4-Dimethylamino Butanal Diethyl Acetal Q: What are the applications of 4-Dimethylamino Butanal Diethyl Acetal Zolmitriptan Related Compound H (4,4-Diethoxy-N,N-dimethylbutan-1-amine) (1727097) 4-Dimethylaminobutyraldebyde Diethyl Acetal 4,4-Diethoxy-N,N-dimethyl-1-butanamine Zolmitriptan Impurity: N,N-Dimethyl amino butanaldiethyl acetal 1116-77-4 116-77-4 CH32NCH23CHOCH2CH32 C10H23NO2 C9 to C10 Amines Building Blocks Nitrogen Compounds Organic Building Blocks Other Products API intermediates Intermediates of Rizatriptan Amines