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ChemicalBook >> CAS DataBase List >>4,4-Diethoxy-N,N-dimethyl-1-butanamine

4,4-Diethoxy-N,N-dimethyl-1-butanamine

4,4-Diethoxy-N,N-dimethyl-1-butanamine Structure
4,4-Diethoxy-N,N-dimethyl-1-butanamine structure
CAS No.
1116-77-4
Chemical Name:
4,4-Diethoxy-N,N-dimethyl-1-butanamine
Synonyms
4,4-diethoxy-N,N-diMethylbutan-1-aMine;4-DIMETHYLAMINO BUTYRALDEHYDE DIETHYL ACETAL;Zolmitriptan Related Compound H;Zolmitriptan USP RC H;Zomitriptan Impurity 05;1-Butanamine,4,4-diethoxy-N,N-;4,4-Diethoxy-N-Dimethylbutylamine;(4,4-DIETHOXY-BUTYL)-DIMETHYL-AMINE;4,4-DIETHOXY-N,N-DIMETHYLBUTANAMINE;Zolmitriptan USP Related Compound H
CBNumber:
CB7176364
Molecular Formula:
C10H23NO2
Molecular Weight:
189.3
MDL Number:
MFCD00671479
MOL File:
1116-77-4.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-28 04:24:21
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4,4-Diethoxy-N,N-dimethyl-1-butanamine Properties

Boiling point 194-195C
Density 0.844 g/mL at 25 °C(lit.)
refractive index n20/D 1.421(lit.)
Flash point 158 °F
storage temp. 2-8°C
solubility Chloroform, Ethyl Acetate
form Oil
pka 9.71±0.28(Predicted)
color Colourless to Pale Yellow
Major Application pharmaceutical (small molecule)
InChI InChI=1S/C10H23NO2/c1-5-12-10(13-6-2)8-7-9-11(3)4/h10H,5-9H2,1-4H3
InChIKey QKXMWBLNSPNBEY-UHFFFAOYSA-N
SMILES C(N(C)C)CCC(OCC)OCC
CAS DataBase Reference 1116-77-4(CAS DataBase Reference)
FDA UNII P64QEI4T0I
UNSPSC Code 41116107
NACRES NA.24

SAFETY

Risk and Safety Statements

Symbol(GHS)  Corrosion (GHS05)
GHS05
Signal word  Danger
Hazard statements  H318
Precautionary statements  P280-P305+P351+P338+P310
Hazard Codes  Xi,C
Risk Statements  41-34-10-36/37/38
Safety Statements  26-36/37/39-16-37
RIDADR  UN 3267 8 / PGIII
WGK Germany  3
HS Code  29225090
Storage Class 8A - Combustible corrosive hazardous materials
Hazard Classifications Eye Dam. 1
NFPA 704
1
2 0

4,4-Diethoxy-N,N-dimethyl-1-butanamine price More Price(48)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 647055 4,4-Diethoxy-N,N-dimethyl-1-butanamine 1116-77-4 5g $121 2026-04-30 Buy
Sigma-Aldrich 1727097 Zolmitriptan Related Compound H United States Pharmacopeia (USP) Reference Standard 1116-77-4 50mg $1460 2026-04-30 Buy
TCI Chemical D3973 4-(Dimethylamino)butyraldehyde Diethyl Acetal >98.0%(GC)(T) 1116-77-4 5g $24 2026-04-30 Buy
TCI Chemical D3973 4-(Dimethylamino)butyraldehyde Diethyl Acetal >98.0%(GC)(T) 1116-77-4 25g $76 2026-04-30 Buy
TRC TRC-D461095-5G 4-Dimethylaminobutyraldehyde Diethyl Acetal 1116-77-4 5g $73 2026-06-03 Buy
Product number Packaging Price Buy
647055 5g $121 Buy
1727097 50mg $1460 Buy
D3973 5g $24 Buy
D3973 25g $76 Buy
TRC-D461095-5G 5g $73 Buy

4,4-Diethoxy-N,N-dimethyl-1-butanamine Chemical Properties, Uses, Production

Chemical Properties

Light yellow liquid

Uses

4,4-Diethoxy-N,N-dimethyl-1-butanamine is used in organic synthesis and pharmaceutical intermediates, it is an intermediate for Sumatriptan, Rizatriptan, Almotriptan, Zolmitriptan.

Application

4-Dimethylaminobutyraldehyde Diethyl Acetal (Zolmitriptan USP Related Compound H) is used in the preparation of N,N-Dimethyltryptamines, 5-HT1D receptor agonists, for medicinal treatments such as antimigraine drugs.

Preparation

4-Dimethylaminobutyraldehyde diethyl acetal synthesis: The reaction of 1-bromo-3-chloro propane and dimethylamine solution with PEG as a phase transfer catalyst, and obtained 3-dimethylamino-1-chloro propane. 3-dimethylamino-1-chloro propane reacted with magnesium and Grinard reagent was acquired. 4-Dimethylaminobutyraldehyde diethyl acetal is obtained by the reaction of Grinard reagent and triethyl orthoformate. The yield was 70.11%.

Synthesis Reference(s)

Tetrahedron Letters, 35, p. 2401, 1994 DOI: 10.1016/0040-4039(94)85230-8

Synthesis

3-Chloro-1-(N,N-dimethyl)propylamine

109-54-6

Triethyl orthoformate

122-51-0

4,4-Diethoxy-N,N-dimethyl-1-butanamine

1116-77-4

Magnesium shavings (25 g) were added to a 2L four-necked round-bottomed flask under nitrogen protection. Benzene (50 mL), benzene solution of 3-chloro-1-(N,N-dimethyl)propylamine (50 mL), triethyl orthoformate (20 g), and a small amount of iodine crystals were added sequentially and slowly heated to reflux temperature. After 15-20 minutes of refluxing, a vigorous reaction was observed, indicating the onset of the Grignard reaction. The remaining benzene solution of 3-chloro-1-(N,N-dimethyl)propylamine and triethyl orthoformate (174 g, where R3 = R5 = Et) were loaded into two charging funnels and added slowly and dropwise to the reaction mixture over a period of 3-4 hr, maintaining reflux. After completion of the reaction, it was cooled to 25 °C and filtered through a diatomaceous earth pad. The filter cake was washed with benzene (100 mL). Benzene was removed by distillation at atmospheric pressure using a 20 cm Vigreux column. The residue was distilled under mild vacuum with a controlled bath temperature below 100 °C to recover excess triethyl orthoformate (60 g). Finally, 4-dimethylaminobutyraldehyde diethyl acetal was purified by reduced pressure distillation to give 125 g (75.8% yield) of a colorless liquid with a boiling point of 140-150°C/15-20 mmHg.

References

[1] Patent: WO2003/101931, 2003, A2. Location in patent: Page 14-15
[2] Patent: WO2003/101931, 2003, A2. Location in patent: Page 15-16
[3] Patent: WO2004/99141, 2004, A1. Location in patent: Page 9-10

4,4-Diethoxy-N,N-dimethyl-1-butanamine synthesis

109-54-6
122-51-0
1116-77-4
Synthesis of 4,4-Diethoxy-N,N-dimethyl-1-butanamine from 3-Chloro-1-(N,N-dimethyl)propylamine and Triethyl orthoformate

4,4-Diethoxy-N,N-dimethyl-1-butanamine Preparation Products And Raw materials

Raw materials

4,4-Diethoxybutylamine Diethyl phenyl orthoformate 3-Chloro-1-(N,N-dimethyl)propylamine Ethanol Triethyl orthoformate
iodine Chloro[3-(dimethylamino)propyl]magnesium Benzene Formaldehyde Magnesium

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Preparation Products

4,4-Diethoxy-N,N-dimethyl-1-butanamine Suppliers

Global Suppliers ( 327)
Supplier Tel Email Country ProdList Advantage
Henan Chongyi Biomedicine Co., Ltd 18257818007 779340002@qq.com China 41 58
Shanghai Taijilin Industrial Co., Ltd. 02150630626 17717886015 kate@tajilin.com China 1340 58
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 4006356688 18621169109 market03@meryer.com China 40202 62
INTATRADE GmbH +49 3493/605464 sales@intatrade.de Germany 3563 66
ZHIWE CHEMTECH CO LTD 021-20221225 13917446399 zwchem@163.com China 527 61
Alfa Aesar 400-6106006 saleschina@alfa-asia.com China 30103 84
TCI (Shanghai) Development Co., Ltd. 021-67121386 Sales-CN@TCIchemicals.com China 24512 81
Energy Chemical 400-0056266 sales8178@energy-chemical.com China 44850 61
Adamas Reagent, Ltd. 400-6009262 15618770481 yhx@titansci.com China 14098 59
Supplier Advantage
Henan Chongyi Biomedicine Co., Ltd 58
Shanghai Taijilin Industrial Co., Ltd. 58
J & K SCIENTIFIC LTD. 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 62
INTATRADE GmbH 66
ZHIWE CHEMTECH CO LTD 61
Alfa Aesar 84
TCI (Shanghai) Development Co., Ltd. 81
Energy Chemical 61
Adamas Reagent, Ltd. 59

View Latest Price from 4,4-Diethoxy-N,N-dimethyl-1-butanamine manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
4,4-Diethoxy-N,N-dimethyl-1-butanamine pictures 2026-09-14 4,4-Diethoxy-N,N-dimethyl-1-butanamine
1116-77-4
 0.99 RongNa Biotechnology Co.,Ltd
4,4-Diethoxy-N,N-dimethyl-1-butanamine pictures 2026-06-30 4,4-Diethoxy-N,N-dimethyl-1-butanamine
1116-77-4
 1kg 99% 10000KGS Shaanxi Dideu New Materials Co. Ltd
4,4-Diethoxy-N,N-dimethyl-1-butanamine pictures 2026-05-28 4,4-Diethoxy-N,N-dimethyl-1-butanamine
1116-77-4
 $2.00-5.00 1KG 99% 10000kg Hebei Chuanghai Biotechnology Co,.LTD

4,4-Diethoxy-N,N-dimethyl-1-butanamine Spectrum

4,4-Diethoxy-N,N-dimethyl-1-butanamine(1116-77-4)1HNMR

1116-77-4 (4,4-Diethoxy-N,N-dimethyl-1-butanamine) Related Search:

Dimethyl disulfide Mefenpyr-diethyl 2,2-Diethoxyethylamine Bromoacetaldehyde diethyl acetal Dacthal
Dimethyl carbonate Dimethyl sulfate Ethylene glycol diethyl ether Dimethyl ether Dimethyl fumarate
POLY(VINYL BUTYRAL) Acetal Metformin Diethyl oxalate Diethyl malonate
N,N-Dimethylformamide Ethane Dimethyl phthalate

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N,N-DIMETHYL-4-AMINOBUTANAL DIETHYL ACETAL N, N-DIMETHYL-4,4-DIETHOXY-1-BUTANAMINE 4-(N,N-DIMETHYLAMINO)BUTANAL DIETHYL ACETAL 4-DIMETHYLAMINO BUTANAL DIETHYL ACETAL (4,4-DIETHOXY-BUTYL)-DIMETHYL-AMINE 4,4-DIETHOXY-N,N-DIMETHYL-1-BUTANAMINE 4,4-DIETHOXY-N,N-DIMETHYLBUTANAMINE 4,4-DIETHOXY-N, N-DIMETHYL-BUTYLAMINE 1-BUTANAMINE 4,4-DIETHOXY-N,N-DIMETHYL 1-Butanamine, 4,4-diethoxy-N,N-dimethyl- S 4,4-Diethoxy-N,N-dimethyl-1-butanamine(DDBA) 1-Butanamine,4,4-diethoxy-N,N- 4,4-diethoxy-N,N-dimethyl-butylamine (intermediate of zolmitriptan and sumatriptan) 4-(N,N-DIMETHYLAMINO)BUTANAL DIETHYL ACETAL(FOR ZOLMITRIPTAN AND OTHER TRIPTANS) 4-(N,N-DIMETHYLAMINO)-BUTYRALDEHYDE DIETHYL ACETAL 4-N,N-DIMETHYLAMINOBUTANAL DIETHYL ACETAL (FOR SUMATRIPTAN, RIZATRIPTAN, ZOLMITRIPTAN) 4-N,N-dimethylaminobutanal diethyl acetal ( For Triptans ) 4,4-DIETHOXY-N,N-DIMETHYL BUTYLAMINE,GC 96+% 4-DimethylamineButyaldehydeDimethylAcetal(ForSumatriptan) 4-Dimethylamine butyaldehyde dimethyl acetal N,N-diethylamino-butyraldehyde diethyl acetal 4,4-Diethoxy-N-Dimethylbutylamine 4-(N,N-Dimethylamino)butyaldehyde diethyl acetal 1-(N,N-Dimethylamino)-4,4-diethoxybutane Zolmitriptan USP RC H 4,4-Diethoxy-N,N-diMethyl-1-butanaMine, 97.5% 4-DiMethylaMinobutanol diethylacetal 4,4-diethoxy-N,N-dimethyl-1-But·Namine 4,4-Diethoxy-N,N-dimethyl-1-butanamine 1116-77-4 1116-77-4 4,4-Diethoxy-N,N-dimethyl-1-butanamine 4,4-Dimethylaminobutyraldehyde diethylacetal Zolmitriptan USP Related Compound H 4-(Dimethylamino)butyraldehydeDiethylAcetal> Zolmitriptan Impurity 10(Zolmitriptan USP RC H) 4,4-Diethoxy-N,N-dimethyl-1-l-butanamine 4-(N,N-Dimethylamino) butane ditheyl acetal 4-Dimethylaminobutyraldehyde Diethyl Acetal/Zolmitriptan USP RC H 4-Dimethylamino Butanal Diethyl AcetalQ: What is 4-Dimethylamino Butanal Diethyl Acetal Q: What is the CAS Number of 4-Dimethylamino Butanal Diethyl Acetal Q: What is the storage condition of 4-Dimethylamino Butanal Diethyl Acetal Q: What are the applications of 4-Dimethylamino Butanal Diethyl Acetal Zolmitriptan Related Compound H (4,4-Diethoxy-N,N-dimethylbutan-1-amine) (1727097) 4-Dimethylaminobutyraldebyde Diethyl Acetal 4,4-Diethoxy-N,N-dimethyl-1-butanamine 4,4-diethoxy-N,N-dimethyl-1-butylamine Zolmitriptan Impurity: N,N-Dimethyl amino butanaldiethyl acetal Zomitriptan Impurity 05 4-DIMETHYLAMINO BUTYRALDEHYDE DIETHYL ACETAL 4,4-diethoxy-N,N-diMethylbutan-1-aMine Zolmitriptan Related Compound H 1116-77-4 116-77-4 CH32NCH23CHOCH2CH32 C10H23NO2 C9 to C10 Amines Building Blocks Nitrogen Compounds Organic Building Blocks Other Products API intermediates