2,3-Dimethylmaleic anhydride
- CAS No.
- 766-39-2
- Chemical Name:
- 2,3-Dimethylmaleic anhydride
- Synonyms
- DIMETHYLMALEIC ANHYDRIDE;Pyrocinchonic anhydride;3,4-Dimethyl-2,5-furandione;2,5-Furandione,3,4-dimethyl-;2,2’-Dimethylmaleinsαureanhydrid;eic Anhydride;pyrocinchonicanhydride;dimethyl-maleicanhydrid;3,4-dimethyl-5-furandione;TwoMethyl Maleic anhydride
- CBNumber:
- CB7179895
- Molecular Formula:
- C6H6O3
- Molecular Weight:
- 126.11
- MDL Number:
- MFCD00005523
- MOL File:
- 766-39-2.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 93-96 °C (lit.) |
|---|---|
| Boiling point | 223 °C (lit.) |
| Density | 1.107 g/cm3 (100℃) |
| refractive index | 1.5627 (estimate) |
| Flash point | 222-223°C |
| storage temp. | Store below +30°C. |
| solubility | Chloroform (Slightly), Ethyl Acetate (Slightly) |
| form | Solid |
| color | White to Off-White |
| Water Solubility | Soluble in ethanol, ether and chloroform. Slightly soluble in water. |
| Sensitive | Moisture Sensitive |
| BRN | 112044 |
| InChI | 1S/C6H6O3/c1-3-4(2)6(8)9-5(3)7/h1-2H3 |
| InChIKey | MFGALGYVFGDXIX-UHFFFAOYSA-N |
| SMILES | CC1=C(C)C(=O)OC1=O |
| LogP | 0.183 (est) |
| CAS DataBase Reference | 766-39-2(CAS DataBase Reference) |
| EWG's Food Scores | 1 |
| FDA UNII | 6PP3N541QA |
| NIST Chemistry Reference | 2,5-Furandione, 3,4-dimethyl-(766-39-2) |
| EPA Substance Registry System | 2,5-Furandione, 3,4-dimethyl- (766-39-2) |
| UNSPSC Code | 12352115 |
| NACRES | NA.23 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302 | |||||||||
| Precautionary statements | P264-P270-P301+P312-P501 | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | Xn,Xi | |||||||||
| Risk Statements | 22 | |||||||||
| Safety Statements | 45-36/37/39-28A-26 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | ON4025000 | |||||||||
| F | 9-21 | |||||||||
| TSCA | TSCA listed | |||||||||
| HS Code | 2917 19 80 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Acute Tox. 4 Oral | |||||||||
| Hazardous Substances Data | 766-39-2(Hazardous Substances Data) | |||||||||
| NFPA 704 |
|
2,3-Dimethylmaleic anhydride price More Price(81)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 8.41502 | 2,3-Dimethylmaleic anhydride for synthesis | 766-39-2 | 5G | $123 | 2026-04-30 | Buy |
| Sigma-Aldrich | D167800 | 2,3-Dimethylmaleic anhydride 98% | 766-39-2 | 5G | $115 | 2023-01-07 | Buy |
| TCI Chemical | D3473 | 2,3-Dimethylmaleic Anhydride >98.0%(GC)(T) | 766-39-2 | 5g | $36 | 2026-04-30 | Buy |
| TCI Chemical | D3473 | 2,3-Dimethylmaleic Anhydride >98.0%(GC)(T) | 766-39-2 | 25g | $116 | 2026-04-30 | Buy |
| Usbiological | 230836 | 2,3-Dimethylmaleic anhydride 98+% ≥98% | 5g | $163 | 2026-06-03 | Buy |
2,3-Dimethylmaleic anhydride Chemical Properties, Uses, Production
Synthesis
A boiling solution of maleic anhydride (128) (196.2 g, 2.0 mol) in AcOH (200 mL) was added dropwise over 1 hour to a boiling solution of 2-aminopyridine (129) (94.1 g, 1.0 mol) in AcOH (200 mL). A strong CO2 evolution was observed. The mixture was heated under reflux for 2.5 hours, and then acetic acid was distilled off through a Claisen bridge. After adding 2 M H2SO4 (600 mL), the mixture was stirred under reflux for 2 hours. After cooling, the precipitated crystals were filtered off and washed with 2 M H2SO4 (3 x 50 mL) and H2O (2 x 50 mL). Light brown flakes (obtained after 24 hours in a desiccator (P2O5)) were sublimated at 60 °C and 0.02 mbar.
Yield: 68.0 g (0.54 mmol, 54%) colorless crystals of 2,3-dimethylmaleic anhydride, Rf(SiO2) = 0.46 (c-hexane/EA 1:1). mp 91-92°C (95°C). 
Figure 2,3-Dimethylmaleic Anhydride Synthetic Route
Chemical Properties
white to beige crystals or cryst. powder
Uses
2,3-Dimethylmaleic anhydride can be usually used in the synthesis of maleimides and as an amino group protecting agent for superoxide dismutase. It is also used in the preparation of dimethylmaleic acid dimethyl ester. Further, it serves as a reactant in the dissociation of ribosomal proteins. In addition to this, The isolated molecule 2, 3-dimethylmaleic anhydride showed potent insecticidal activity in fumigation bioassay against several insect species, viz., adults of houseflies, cockroaches and stored-product insects.
Definition
ChEBI: 2,3-Dimethylmaleic anhydride is a butenolide. It is a 5-membered cyclic anhydride with a double bond between carbon atoms C2 and C3. The double bond locks the molecule in a planar conformation and stabilizes the acid anhydride against hydration. It was used as linker to a cell penetrating peptidebased nanoparticle.
Safety Profile
Questionable carcinogen with experimental tumorigenic data. When heated to decomposition it emits acrid smoke and irritating fumes. See also ANHYDRIDES.
Purification Methods
Distil the anhydride from *benzene/ligroin and sublime in a vacuum. [Beilstein 17/11 V 69.]
2,3-Dimethylmaleic anhydride Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Quzhou HuntBio Co., Ltd. | 0571-64067827 13372408495 | sales@huntchem.com | China | 76 | 60 |
| Jiangsu Huayu Chemical Co., Ltd. | 25-83241163 | sales@elegantnutri.com | China | 55 | 55 |
| Chemspon Bio-Tech Co., Ltd | 0571-88937695 88937835 13606537248 | sales@chemspon.com | China | 257 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| ShangHai DEMO Chemical Co.,Ltd | 400-021-7337 2355568890 | sales@demochem.com | China | 2569 | 57 |
| Ark Pharm, Inc. | 847-367-3680 | sales@arkpharminc.com | United States | 1669 | 56 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
View Latest Price from 2,3-Dimethylmaleic anhydride manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2019-07-06 | 2,3-Dimethylmaleic anhydride
766-39-2
|
$1.00 | 1KG | 99% | Career Henan Chemical Co |
-
- 2,3-Dimethylmaleic anhydride
766-39-2
- $1.00
- 99%
- Career Henan Chemical Co
