ChemicalBook >> CAS DataBase List >>H-Cys-Thr-Cys-Phe-Thr-Tyr-Lys-Asp-Lys-Glu-Cys-Val-Tyr-Tyr-Cys-His-Leu-Asp-Ile-Ile-Trp-OH

H-Cys-Thr-Cys-Phe-Thr-Tyr-Lys-Asp-Lys-Glu-Cys-Val-Tyr-Tyr-Cys-His-Leu-Asp-Ile-Ile-Trp-OH

H-Cys-Thr-Cys-Phe-Thr-Tyr-Lys-Asp-Lys-Glu-Cys-Val-Tyr-Tyr-Cys-His-Leu-Asp-Ile-Ile-Trp-OH structure

CAS No.: 117399-93-6

Chemical Name:: H-Cys-Thr-Cys-Phe-Thr-Tyr-Lys-Asp-Lys-Glu-Cys-Val-Tyr-Tyr-Cys-His-Leu-Asp-Ile-Ile-Trp-OH

Synonyms: et-3;EDN3;WS4B;HSCR4;PPET3;human,rat;ET-3, HUMAN;ENDOTHELIN-3;CAS:117399-93-6;Rat endothelin-3

CBNumber:: CB7181630

Molecular Formula:: C121H168N26O33S4

Molecular Weight:: 2643.04

MDL Number:: MFCD00076378

MOL File:: 117399-93-6.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-09-12 18:54:43

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H-Cys-Thr-Cys-Phe-Thr-Tyr-Lys-Asp-Lys-Glu-Cys-Val-Tyr-Tyr-Cys-His-Leu-Asp-Ile-Ile-Trp-OH Properties

Density	1.285±0.06 g/cm3(Predicted)
storage temp.	−20°C
solubility	5% acetic acid: 0.5mg/mL
form	powder
color	white
biological source	rabbit
Water Solubility	Soluble to 1 mg/ml in water
Sequence	Cys-Thr-Cys-Phe-Thr-Tyr-Lys-Asp-Lys-Glu-Cys-Val-Tyr-Tyr-Cys-His-Leu-Asp-Ile-Ile-Trp(Disulfide bridge: Cys1-Cys15, Cys3-Cys11)
InChIKey	OQGZWNZGVYLIFX-XKIQDWPYSA-N
FDA UNII	0066WLJ02E
UNSPSC Code	12352203
NACRES	NA.77

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS06
Signal word	Danger
Hazard statements	H300+H330
Precautionary statements	P301+P310+P330-P304+P340+P310
Safety Statements	22
WGK Germany	3
F	3-10
Storage Class	6.1A - Combustible acute toxic Cat. 1 and 2 very toxic hazardous materials

H-Cys-Thr-Cys-Phe-Thr-Tyr-Lys-Asp-Lys-Glu-Cys-Val-Tyr-Tyr-Cys-His-Leu-Asp-Ile-Ile-Trp-OH price More Price(43)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	E9137	Endothelin 3 human, rat ≥97%(HPLC),powder	117399-93-6	10μg	$141	2026-04-30	Buy
Sigma-Aldrich	E9137	Endothelin 3 human, rat ≥97%(HPLC),powder	117399-93-6	50μg	$417	2026-04-30	Buy
Sigma-Aldrich	E9137	Endothelin 3 human, rat ≥97%(HPLC),powder	117399-93-6	0.1mg	$787	2026-04-30	Buy
Sigma-Aldrich	05-23-3801	Endothelin 3, Human and Rat Attenuates thrombin-evoked aggregation of human platelets.	117399-93-6	0.5MG	$563	2026-04-30	Buy
Sigma-Aldrich	SAB1410319	Anti-EDN3 antibody produced in rabbit purified immunoglobulin, buffered aqueous solution		100 μg	$541	2025-07-31	Buy

Product number	Packaging	Price	Buy
E9137	10μg	$141	Buy
E9137	50μg	$417	Buy
E9137	0.1mg	$787	Buy
05-23-3801	0.5MG	$563	Buy
SAB1410319	100 μg	$541	Buy

H-Cys-Thr-Cys-Phe-Thr-Tyr-Lys-Asp-Lys-Glu-Cys-Val-Tyr-Tyr-Cys-His-Leu-Asp-Ile-Ile-Trp-OH Chemical Properties, Uses, Production

Uses

Endothelin 3 human, rat has been used for culturing neural tube explant culture, and the pharmacological study of endothelin receptors.

General Description

Endothelin 3 (ET3) belongs to endothelin peptide family, which includes three members, ET-1, -2 and -3. These are 21-amino acid peptides, which are synthesized as precursors. They are converted to biologically active peptides, after being cleaved by proteases. There are two endothelin receptors called ETRA and ETRB, and ET3 binds to ETRB. It is localized to human intestine and colon.

Biochem/physiol Actions

Endothelin 3 (ET3) is a vasoconstrictor that acts in a paracrine and autocrine manner, and in intestinal lamina propria causes the degranulation of mast cells. It results in the release of ions from intestinal epithelial cells. In acute and chronic intestinal inflammation, it is overexpressed. It is also up-regulated in colon carcinoma, where it supports cell proliferation and survival. It might be involved in colon homeostasis, and is essential for the survival and proliferation of goblet cells. In mice, it is essential for the development of pigment cells derived from neural crest (NC). Its expression is de-regulated in metastatic melanoma.

in vivo

Endothelin-3 at low concentrations may attenuate inflammatory responses via ETB2 activation and NO production. Endothelin-3, which acts mainly on ETB, at low concentrations specifically inhibited platelet-activating factor (PAF)-induced paw oedema, whereas neither ET-1 nor Endothelin-2, both of which act on ETA and ETB, showed inhibitory activity. The inhibition by ET-1 and Endothelin-3 (each 0.5 pmol/paw) in the presence of BQ-123 (66.4 ± 6.7 % and 65.4 ± 22.6 %, respectively), is comparable to that by Endothelin-3 (0.5 pmol/paw) alone (65.4 ± 10.9 %), whereas neither ET-1 nor Endothelin-3 in the presence of BQ-788 showed inhibitory activity^[3].

storage

Store at -20°C

H-Cys-Thr-Cys-Phe-Thr-Tyr-Lys-Asp-Lys-Glu-Cys-Val-Tyr-Tyr-Cys-His-Leu-Asp-Ile-Ile-Trp-OH Preparation Products And Raw materials

Raw materials

Preparation Products

H-Cys-Thr-Cys-Phe-Thr-Tyr-Lys-Asp-Lys-Glu-Cys-Val-Tyr-Tyr-Cys-His-Leu-Asp-Ile-Ile-Trp-OH Suppliers

Global Suppliers ( 132)

Supplier	Tel	Email	Country	ProdList	Advantage
GL Biochem (Shanghai) Ltd	21-61263452 13641803416	ymbetter@glbiochem.com	China	9981	64
Shanghai Hanhong Scientific Co.,Ltd.	021-54306202 13764082696	info@hanhongsci.com	China	42917	64
Chemsky（shanghai）International Co.,Ltd.	021-50135380	shchemsky@sina.com	China	32273	50
Cellmano Biotech Limited	0551-65326643 18156095617	info@cellmano.com	China	1010	55
Chengdu HuaXia Chemical Reagent Co. Ltd	400-1166-196 13458535857	cdhxsj@163.com	China	13323	58
Wuxi Zhongkun Biochemical Technology Co., Ltd.	0510-85629785 18013409632;	sales@reading-chemicals.com	China	15165	58
Sigma-Aldrich	021-61415566 800-8193336	orderCN@merckgroup.com	China	51389	80
Watson Biotechnology Co.,Ltd	027-59207879 1972026995 18140587686	sales@3600chem.com	China	4193	55
Creative Peptides		info@creative-peptides.com	United States	6083	56
Shanghai Xilong Biochemical Technology Co., Ltd.	021-52907766-8042		China	9928	58

Supplier	Advantage
GL Biochem (Shanghai) Ltd	64
Shanghai Hanhong Scientific Co.,Ltd.	64
Chemsky（shanghai）International Co.,Ltd.	50
Cellmano Biotech Limited	55
Chengdu HuaXia Chemical Reagent Co. Ltd	58
Wuxi Zhongkun Biochemical Technology Co., Ltd.	58
Sigma-Aldrich	80
Watson Biotechnology Co.,Ltd	55
Creative Peptides	56
Shanghai Xilong Biochemical Technology Co., Ltd.	58

View Latest Price from H-Cys-Thr-Cys-Phe-Thr-Tyr-Lys-Asp-Lys-Glu-Cys-Val-Tyr-Tyr-Cys-His-Leu-Asp-Ile-Ile-Trp-OH manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2020-02-13	H-CYS-THR-CYS-PHE-THR-TYR-LYS-ASP-LYS-GLU-CYS-VAL-TYR-TYR-CYS-HIS-LEU-ASP-ILE-ILE-TRP-OH 117399-93-6	$7.00	1KG	99%	100KG	Career Henan Chemical Co
	2020-02-13	H-CYS-THR-CYS-PHE-THR-TYR-LYS-ASP-LYS-GLU-CYS-VAL-TYR-TYR-CYS-HIS-LEU-ASP-ILE-ILE-TRP-OH 117399-93-6	$7.00	1KG	99%	100KG	Career Henan Chemical Co

H-CYS-THR-CYS-PHE-THR-TYR-LYS-ASP-LYS-GLU-CYS-VAL-TYR-TYR-CYS-HIS-LEU-ASP-ILE-ILE-TRP-OH
117399-93-6
$7.00
99%
Career Henan Chemical Co

H-CYS-THR-CYS-PHE-THR-TYR-LYS-ASP-LYS-GLU-CYS-VAL-TYR-TYR-CYS-HIS-LEU-ASP-ILE-ILE-TRP-OH
117399-93-6
$7.00
99%
Career Henan Chemical Co

117399-93-6 (H-Cys-Thr-Cys-Phe-Thr-Tyr-Lys-Asp-Lys-Glu-Cys-Val-Tyr-Tyr-Cys-His-Leu-Asp-Ile-Ile-Trp-OH) Related Search:

Big ET-1 (1-38) (human) H-Cys-Ser-Cys-Ser-Ser-Trp-Leu-Asp-Lys-Glu-Cys-Val-Tyr-Phe-Cys-His-Leu-Asp-Ile-Ile-Trp-OH IRL-1038 Endothelin-1 (human, porcine) Endothelin (16-21)

Glycyl-L-tryptophan Dipeptide-2 H-Val-Gly-Gly-OH H-Leu-beta-Ala-OH L-Alanyl-L-tryptophan

H-Ile-Trp-OH H-Ile-Ala-OH H-Cys-Thr-Cys-Phe-Thr-Tyr-Lys-Asp-Lys-Glu-Cys-Val-Tyr-Tyr-Cys-His-Leu-Asp-Ile-Ile-Trp-OH H-Gly-Gly-Trp-OH Ac-Phe-Tyr-NH2

Ac-His-NHMe Glycyl-DL-tryptophan H-Cys-Thr-Cys-Phe-Thr-Tyr-Lys-Asp-Lys-Glu-Cys-Val-Tyr-Tyr-Cys-His-Leu-Asp-Ile-Ile-Trp-OH

1of4

ENDOTHELIN-III, HUMAN, RAT ENDOTHELIN-3 ENDOTHELIN-3, HUMAN ENDOTHELIN 3, HUMAN AND RAT ENDOTHELIN-3 (HUMAN, MOUSE, RABBIT, RAT) ENDOTHELIN-3 (HUMAN) (PORCINE, RAT, RABBIT) ENDOTHELIN 3 HUMAN, RAT ENDOTHELIN-3 (HUMAN, RAT, PIG) ENDOTHELIN-3 (HUMAN, RAT, PORCINE, RABBIT) CYS-THR-CYS-PHE-THR-TYR-LYS-ASP-LYS-GLU-CYS-VAL-TYR-TYR-CYS-HIS-LEU-ASP-ILE-ILE-TRP CYS-THR-CYS-PHE-THR-TYR-LYS-ASP-LYS-GLU-CYS-VAL-TYR-TYR-CYS-HIS-LEU-ASP-ILE-ILE-TRP HUMAN, RAT, PORCINE, RABBIT CTCFTYKDKECVYYCHLDIIW CTCFTYKDKECVYYCHLDIIW (DISULFIDE BRIDGE: 1-15 AND 3-11) H-CYS-THR-CYS-PHE-THR-TYR-LYS-ASP-LYS-GLU-CYS-VAL-TYR-TYR-CYS-HIS-LEU-ASP-ILE-ILE-TRP-OH (DISULFIDE BRIDGE: 1-15 AND 3-11) ET-3, HUMAN ET-3, HUMAN AND RAT ET-3 (HUMAN, MOUSE, RABBIT, RAT) ET-3 (HUMAN, RAT) ET-3 (HUMAN, RAT, PIG) ENDOTHELIN 3, HUMAN, RAT, 50 UG* human,rat et-3 M.W. 2643.04 C121H168N26O33S4 Endothelin 3【canine】 Endothelin 3【rabbit】 Endothelin 3【rat】 CYS-THR-CYS-PHE-THR-TYR-LYS-ASP-LYS-GLU-CYS-VAL-TYR- TYR-CYS-HIS-LEU-ASP-ILE-ILE-TRP(DISULFIDE BRIDGE:CYS1-CYS15, CYS3-CYS11) CYS-THR-CYS-PHE-THR-TYR-LYS-ASP-LYS-GLU-CYS-VAL-TYR-TYR-CYS-HIS-LEU-ASP-ILE-ILE-TRP: CTCFTYKDKECVYYCHLDIIW DISULFIDE BRIDGES CYS1-CYS15, CYS3-CYS11 Endothelin-3 (huMan, Mouse, rabbit, rat) ET-3 (huMan, Mouse, rabbit, rat) Cys-Thr-Cys-Phe-Thr-Tyr-Lys-Asp-Lys-Glu-Cys-Val-Tyr-Tyr-Cys-His-Leu-Asp-Ile-Ile-Trp (Disulfide bridges Cys1-Cys15 and Cys3-Cys11) Endothelin 3 huMan, ratEndothelin Endothelin 3 (huMan)(9CI) Anti-EDN3 antibody produced in rabbit EDN3 HSCR4 ANTI-EDN3 (C-TERM) antibody produced in rabbit 19: PN: WO2007112069 SEQID: 10 claimed protein 33,34,49,50-Tetrathia-2,5,8,11,14,17,20,23,26,29,37,40,43,46-tetradecaazabicyclo[23.22.4]henpentacontane, cyclic peptide deriv. Endothelin 3 (mouse intestine) Human endothelin-3 Rat endothelin-3 Endothelin 3, human, rat, ≥97% (HPLC), powder Endothelin 3, Human and Rat - CAS 117399-93-6 - Calbiochem Endothelin 3 (Rat,Human) L-Tryptophan, L-cysteinyl-L-threonyl-L-cysteinyl-L-phenylalanyl-L-threonyl-L-tyrosyl-L-lysyl-L-α-aspartyl-L-lysyl-L-α-glutamyl-L-cysteinyl-L-valyl-L-tyrosyl-L-tyrosyl-L-cysteinyl-L-histidyl-L-leucyl-L-α-aspartyl-L-isoleucyl-L-isoleucyl-, cyclic (1→15),(3→11)-bis(disulfide) H-CYS-THR-CYS-PHE-THR-TYR-LYS-ASP-LYS-GLU-CYS-VAL-TYR-TYR-CYS-HIS-LEU-ASP-ILE-ILE-TRP-OH USP/EP/BP Endothelin 3 human, rat (TFA) Human endothelin-3/Rat endothelin-3 CAS:117399-93-6 Endothelin 3, human, rat, mouse, rabbit (3S)-3-[[(2S)-2-[[(2S)-2-[[(1R,4S,7S,10S,13S,16S,19S,22S,25R,28S,31R,36R,39S,42S,45S)-31-amino-7,13-bis(4-aminobutyl)-22-benzyl-4-(2 -carboxyethyl)-10-(carboxymethyl)-19,28-bis[(1R)-1-hydroxyethyl]-16,39,42-tris[(4-hydroxyphenyl)methyl]-3,6,9,12,15,18,21, PPET3 WS4B H-Cys-Thr-Cys-Phe-Thr-Tyr-Lys-Asp-Lys-Glu-Cys-Val-Tyr-Tyr-Cys-His-Leu-Asp-Ile-Ile-Trp-OH 117399-93-6 C121H168N26O33S4 Agonist BioChemical