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BQ-123

BQ-123 structure

CAS No.: 136553-81-6

Chemical Name:: BQ-123

Synonyms: ONIST;BQ-123;BQ-518;PMZ 2123;BQ-123 SODIUM SALT;BQ-123;BQ 123;BQ123;BQ-123, 10 mM in DMSO;ETA-RECEPTOR ANTAGONIST;M.W. 610.70 C31H42N6O7;C(DTRP-DASP-PRO-DVAL-LEU)

CBNumber:: CB7188725

Molecular Formula:: C31H42N6O7

Molecular Weight:: 610.7

MDL Number:: MFCD00133204

MOL File:: 136553-81-6.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-09-10 08:17:50

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BQ-123 Properties

Boiling point	1053.6±65.0 °C(Predicted)
Density	1.33±0.1 g/cm3(Predicted)
storage temp.	-20°C
solubility	Soluble to 0.40 mg/ml in sterile
form	lyophilized powder
pka	4.04±0.10(Predicted)
color	White to off-white
Water Solubility	Soluble in water (0.4 mg/ml)
Sequence	Cyclo(d-Asp-Pro-d-Val-Leu-d-Trp)
FDA UNII	S2A8YZM151
UNSPSC Code	12352204
NACRES	NA.77

SAFETY

Risk and Safety Statements

Safety Statements	22-24/25
WGK Germany	3
Storage Class	11 - Combustible Solids

BQ-123 price More Price(72)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	B150	BQ-123 ≥99%, sodium salt, lyophilized powder	136553-81-6	200μg	$179	2026-04-30	Buy
Sigma-Aldrich	B150	BQ-123 ≥99%, sodium salt, lyophilized powder	136553-81-6	1mg	$513	2026-04-30	Buy
Sigma-Aldrich	05-23-3831	BQ-123, Sodium Salt A highly potent, selective, and competitive ETA (endothelin) receptor antagonist (Ki = 40 nM for ETA versus Ki = 2.5 μM for ETB).		1MG	$215	2026-04-30	Buy
Sigma-Aldrich	05-23-3831	BQ-123, Sodium Salt A highly potent, selective, and competitive ETA (endothelin) receptor antagonist (Ki = 40 nM for ETA versus Ki = 2.5 μM for ETB).		5MG	$789	2023-06-20	Buy
Cayman Chemical	19153	BQ-123 ≥95%	136553-81-6	1mg	$117	2026-04-30	Buy

Product number	Packaging	Price	Buy
B150	200μg	$179	Buy
B150	1mg	$513	Buy
05-23-3831	1MG	$215	Buy
05-23-3831	5MG	$789	Buy
19153	1mg	$117	Buy

BQ-123 Chemical Properties,Uses,Production

Uses

BQ-123 has been used as a selective endothelin-A receptor antagonist to study its effects on tumor necrosis factor α (TNFα)-induced human airway smooth muscle cells (HASMCs) proliferation. It is also used as endothelin-A receptor antagonist to study its effects on TNFα-induced granulocyte–macrophage colony-stimulating factor (GM-CSF) expression.

Definition

ChEBI: BQ 123 is a cyclic peptide.

Biological Activity

bq-123 is a potent and selective antagonist of eta endothelin receptor with ki values of 1.4 and 1500 nm for eta and etb receptors, respectively.endothelin receptor is a g protein-coupled receptor. eta receptor increases intracellular-free ca2+. also, activation of eta receptor increases vasoconstriction and blood pressure.bq-123 is a selective eta receptor antagonist. in the eta-expressing cells, bq123 (10-6 m) inhibited endothelin-1 (et-1) (10-6 m)-induced [ca2+]i increase by 95% [1]. in rat vascular smooth muscle cells (vsmc), bq-123 inhibited et-1 receptor binding, cellular contraction, [ca2+ ]i mobilization, [3h]thymidine incorporation, map kinase activation and mtt reduction induced by et-1. however, bq-123 didn’t inhibit angiotensin ii (ang ii)- and arginine vasopressin (avp)-induced increases in map kinase activity and [ca2+]i mobilization [2].in spontaneously hypertensive rats (shr), renin hypertensive rats and normotensive rats, bq-123 (16 nm/kg/min) reduced mean arterial pressure in a dose-dependent way in shr. also, bq-123 lowered blood pressure in both renin hypertensive rats and normotensive rats [3]. in a kidney transplantation rat model with reperfusion injury, bq-123 prevented reperfusion injury and inhibited the synthesis and release of et-1,2 [4].

Biochem/physiol Actions

Selective ETA endothelin receptor antagonist.

storage

-20°C

References

[1]. sakamoto a, yanagisawa m, sawamura t, et al. distinct subdomains of human endothelin receptors determine their selectivity to endothelina-selective antagonist and endothelinb-selective agonists. j biol chem, 1993, 268(12): 8547-8553.
[2]. guo x, okada k, fujita n, et al. inhibitory effect of bq-123 on endothelin-1-stimulated mitogen-activated protein kinase and cell growth of rat vascular smooth muscle cells. hypertens res, 1996, 19(1): 23-30.
[3]. douglas sa, gellai m, ezekiel m, et al. bq-123, a selective endothelin subtype a-receptor antagonist, lowers blood pressure in different rat models of hypertension. j hypertens, 1994, 12(5): 561-567.
[4]. büyükgebiz o, aktan ao, haklar g, et al. bq-123, a specific endothelin (eta) receptor antagonist, prevents ischemia-reperfusion injury in kidney transplantation. transpl int, 1996, 9(3): 201-207.

BQ-123 Preparation Products And Raw materials

Raw materials

Preparation Products

BQ-123 Suppliers

Global( 162)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
3B Pharmachem (Wuhan) International Co.,Ltd.	18930552037	3bsc@sina.com	China	15813	69
GL Biochem (Shanghai) Ltd	21-61263452 13641803416	ymbetter@glbiochem.com	China	9981	64
Shanghai Hanhong Scientific Co.,Ltd.	021-54306202 13764082696	info@hanhongsci.com	China	42917	64
Chemsky（shanghai）International Co.,Ltd.	021-50135380	shchemsky@sina.com	China	32273	50
Cellmano Biotech Limited	0551-65326643 18156095617	info@cellmano.com	China	1010	55
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.	025-66113011 13913916777	cfzhang@aikonchem.com	China	19902	55
Haoyuan Chemexpress Co., Ltd.	021-58950125	info@chemexpress.com	China	7545	61
Bide Pharmatech Ltd.	400-164-7117 18317119277	product02@bidepharm.com	China	40000	60
Wuxi Zhongkun Biochemical Technology Co., Ltd.	0510-85629785 18013409632;	sales@reading-chemicals.com	China	15165	58

Supplier	Advantage
J & K SCIENTIFIC LTD.	76
3B Pharmachem (Wuhan) International Co.,Ltd.	69
GL Biochem (Shanghai) Ltd	64
Shanghai Hanhong Scientific Co.,Ltd.	64
Chemsky（shanghai）International Co.,Ltd.	50
Cellmano Biotech Limited	55
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.	55
Haoyuan Chemexpress Co., Ltd.	61
Bide Pharmatech Ltd.	60
Wuxi Zhongkun Biochemical Technology Co., Ltd.	58

View Lastest Price from BQ-123 manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2026-09-10	BQ-123 136553-81-6	$80.00-347.00		99.22%	10g	TargetMol Chemicals Inc.
	2020-02-14	BQ-123 SODIUM SALT 136553-81-6	$7.00	1KG	99%	100kg	Career Henan Chemical Co

BQ-123
136553-81-6
$80.00-347.00
99.22%
TargetMol Chemicals Inc.

BQ-123 SODIUM SALT
136553-81-6
$7.00
99%
Career Henan Chemical Co

BQ-123 Spectrum

BQ-123 SODIUM SALT(136553-81-6)¹HNMR

136553-81-6(BQ-123)Related Search:

BQ-123 JKC-301 [3H]BQ 123 C(DILE-LEU-DTRP-DASP-PRO) 5-oxoprolyltryptophan

L-Tryptophan, L-isoleucyl-L-alanyl-L-leucyl-L-tyrosyl-L-leucyl-L-glutaminyl-L-glutaminyl-L-asparaginyl-

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BQ-123 SYNTHETIC >99% SELECTIVE ETA ENDO THE cyclo(Trp-Asp-Pro-Val-Leu) BQ-123 BQ-123 SODIUM SALT ETA-RECEPTOR ANTAGONIST C(DTRP-DASP-PRO-DVAL-LEU) CYCLO (D-ALPHA-ASPARTYL-L-PROLYL-D-VALYL-L-LEUCYL-D-TRYPTOPHYL) CYCLO(D-ASP-PRO-D-VAL-LEU-D-TRP) CYCLO(D-ASP-PRO-D-VAL-LEU-DTRP NA) CYCLO(-D-TRP-D-ASP-PRO-D-VAL-LEU) CYCLO (-D-TRP-D-ASP-PRO-D-VAL-LEU) SODIUM SALT D-TRP-D-ASP-PRO-D-VAL-LEU M.W. 610.70 C31H42N6O7 BQ-518 Cyclo(D-Asp-L-Pro-D-Val-L-Leu-D-Trp-) Cyclo(D-Trp-D-Asp-L-Pro-D-Val-L-Leu-) Cyclo[D-Asp-L-Pro-D-Val-L-Leu-D-Trp-] BQ-123;BQ 123;BQ123 2-[(3R,6R,9S,12R,15S)-6-(1H-indol-3-ylmethyl)-9-(2-methylpropyl)-2,5,8,11,14-pentaoxo-12-propan-2-yl-1,4,7,10,13-pentazabicyclo[13.3.0]octadecan-3-yl]acetic acid PMZ 2123 Cyclo(D-α-aspartyl-L-prolyl-D-valyl-L-leucyl-D-tryptophyl) BQ-123 >=99%, sodium salt, lyophilized powder Cyclo(D-α-aspartyl-L-prolyl-D-valyl-L-leucyl-D-tryptophyl 2-((3R,6S,9R,12R,17aS)-9-((1H-indol-3-yl)methyl)-6-isobutyl-3-isopropyl-1,4,7,10,13-pentaoxohexadecahydro-1H-pyrrolo[1,2-a][1,4,7,10,13]pentaazacyclopentadecin-12-yl)acetic acid 136553-81-6 BQ-123 SODIUM SALT ONIST ETA-Receptor Antagonist [BQ-123] sodium salt inhibit,blood,Endothelin Receptor,artery,BQ-123,pressure,muscle,smooth,cells,BQ 123,Inhibitor,pulmonary BQ-123, ETA receptor antagonist BQ-123, 10 mM in DMSO 136553-81-6 C31H42N6O7 Endothelins Peptides Antagonists Amino Acids and Peptides Biochemicals and Reagents BioChemical Antagonists Endothelins Peptides for Cell Biology Endothelin receptor