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Ethyl 2-amino-5-bromonicotinate

Ethyl 2-amino-5-bromonicotinate structure

CAS No.: 433226-06-3

Chemical Name:: Ethyl 2-amino-5-bromonicotinate

Synonyms: Ethyl 2-amino-5-bromonicotinate;Ethyl 2-amino-5-bromopyridine-3-carboxylate;3-Pyridinecarboxylic acid, 2-aMino-5-broMo-, ethyl ester;Ethyl 2-amino-5-bromopyridine-3-carboxylate, 2-Amino-5-bromo-3-(ethoxycarbonyl)pyridine

CBNumber:: CB7203169

Molecular Formula:: C8H9BrN2O2

Molecular Weight:: 245.07

MDL Number:: MFCD08276943

MOL File:: Mol file

MSDS File:: SDS

Last updated:2026-09-12 18:54:44

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Ethyl 2-amino-5-bromonicotinate Properties

Melting point	139-141°
Boiling point	290.6±35.0 °C(Predicted)
Density	1.575±0.06 g/cm3(Predicted)
storage temp.	Keep in dark place,Inert atmosphere,Room temperature
pka	2.59±0.49(Predicted)
Appearance	Light yellow to yellow Solid

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302+H312+H332-H315-H319-H335
Precautionary statements	P280
Hazard Codes	Xi
HazardClass	IRRITANT
HS Code	2933399990

Ethyl 2-amino-5-bromonicotinate price More Price(35)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Apolloscientific	OR15331	Ethyl 2-amino-5-bromonicotinate 95%	433226-06-3	10g	$64	2026-06-04	Buy
Matrix Scientific	042882	Ethyl 2-amino-5-bromonicotinate	433226-06-3	5.00g	$55	2026-05-18	Buy
Matrix Scientific	042882	Ethyl 2-amino-5-bromonicotinate	433226-06-3	10.00g	$107	2026-05-18	Buy
Matrix Scientific	042882	Ethyl 2-amino-5-bromonicotinate	433226-06-3	25.00g	$244	2026-05-18	Buy
Synthonix	E49175	Ethyl 2-amino-5-bromonicotinate 97%	433226-06-3	1g	$60.44	2026-05-06	Buy

Product number	Packaging	Price	Buy
OR15331	10g	$64	Buy
042882	5.00g	$55	Buy
042882	10.00g	$107	Buy
042882	25.00g	$244	Buy
E49175	1g	$60.44	Buy

Ethyl 2-amino-5-bromonicotinate Chemical Properties, Uses, Production

Synthesis

13362-26-0

433226-06-3

General procedure for the synthesis of ethyl 2-amino-5-bromonicotinate from ethyl 2-aminonicotinate: to a stirred solution of ethyl 2-aminonicotinate (15 g; 90.36 mmol; 1 eq.) in anhydrous THF (150 mL) was added N-bromosuccinimide (NBS) (16 g; 90.36 mmol; 1 eq.) in batches at 0 °C. The resulting mixture was stirred at 23 °C for 18 hours. Upon completion of the reaction, the mixture was poured into ice-cold saturated aqueous NaHCO3 solution and the organic components were extracted with ethyl acetate (3 x 200 mL). The combined organic layers were washed with brine solution, dried over anhydrous sodium sulfate, filtered and concentrated to dryness under reduced pressure to afford ethyl 2-amino-5-bromonicotinate (22 g, 100%) as an off-white solid. The product was confirmed by 1H NMR (DMSO-d6): δ 8.29 (d, 1H, J = 3Hz), 8.12 (d, 1H, J = 2Hz), 7.31 (s, 2H), 4.29 (q, 2H, J = 7Hz), 1.30 (t, 3H, J = 7Hz).The LCMS analysis resulted in: m/z = 245.0 [M + H]+, 247.0 [M + 2H]+, retention time (RT) = 3.34 min (program P1, column W).

References

[1] Patent: WO2015/95128, 2015, A1. Location in patent: Paragraph 0239; 0242; 0243
[2] European Journal of Medicinal Chemistry, 2018, vol. 158, p. 236 - 246
[3] Patent: CN104402881, 2016, B. Location in patent: Paragraph 0022; 0023
[4] Patent: WO2007/67416, 2007, A2. Location in patent: Page/Page column 64; 134

Ethyl 2-amino-5-bromonicotinate Preparation Products And Raw materials

Raw materials

Ethyl 2-aminopyridine-3-carboxylate Methyl 2-aminonicotinate Tetrahydrofuran N-Bromosuccinimide

Preparation Products

Ethyl 2-amino-5-bromonicotinate Suppliers

Global Suppliers ( 53)

Supplier	Tel	Email	Country	ProdList	Advantage
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	4006356688 18621169109	market03@meryer.com	China	40202	62
Wuhan Chemwish Technology Co., Ltd	86-027-67849912	sales@chemwish.com	China	35884	56
Hangzhou Sage Chemical Co., Ltd.	+86057186818502 13588463833	info@sagechem.com	China	10265	58
Nanjing Chalf-Pharm Technology Co., Ltd.	025-57018978 18251899859	sales@chalf-pharm.com	China	5855	50
NovoChemy Ltd.	86-(0)21-31261262 373522135	sales@novochemy.com	China	6491	58
Shangdong Youbang Biochemical Technology Co.,LTD.	15098208899	3368029756@qq.com	China	292	58
Shanghai QianYan Bio-technology Co., Ltd	02781293128	orders@biochemsafebuy.com	China	9904	55
Changzhou Hopschain Chemical Co.,Ltd.	85528066 13775048983	sales@hopschem.com	China	31548	55
Amadis Chemical Company Limited	571-89925085	sales@amadischem.com	China	131885	58

Supplier	Advantage
J & K SCIENTIFIC LTD.	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	62
Wuhan Chemwish Technology Co., Ltd	56
Hangzhou Sage Chemical Co., Ltd.	58
Nanjing Chalf-Pharm Technology Co., Ltd.	50
NovoChemy Ltd.	58
Shangdong Youbang Biochemical Technology Co.,LTD.	58
Shanghai QianYan Bio-technology Co., Ltd	55
Changzhou Hopschain Chemical Co.,Ltd.	55
Amadis Chemical Company Limited	58

Ethyl 2-amino-5-bromonicotinate Spectrum

ETHYL 2-AMINO-5-BROMONICOTINATE(433226-06-3)¹HNMR

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Ethyl 2-amino-5-bromopyridine-3-carboxylate Ethyl 2-amino-5-bromopyridine-3-carboxylate, 2-Amino-5-bromo-3-(ethoxycarbonyl)pyridine 3-Pyridinecarboxylic acid, 2-aMino-5-broMo-, ethyl ester Ethyl 2-amino-5-bromonicotinate 433226-06-3 139-141