3-Aminopiperidine dihydrochloride
- CAS No.
- 138060-07-8
- Chemical Name:
- 3-Aminopiperidine dihydrochloride
- Synonyms
- piperidin-3-amine;3-AMINOPIPERIDINE 2HCL;3-AMINOPIPERIDINEHCL;3-AMINOPIPERIDINEDIHCL;Linagliptin Impurity 91;3-aminopiperidine hydrochloride;piperidin-3-amine hydrochloride;3-Piperidinamine dihydrochloride;3-AMINOPIPERIDINE DIHYDROCHLORIDE;Piperidin-3-amine dihydrochloride
- CBNumber:
- CB7205466
- Molecular Formula:
- C5H14Cl2N2
- Molecular Weight:
- 173.08
- MDL Number:
- MFCD00012773
- MOL File:
- 138060-07-8.mol
- MSDS File:
- SDS
| Melting point | 230 °C (dec.)(lit.) |
|---|---|
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | Methanol (Sparingly), Water (Slightly) |
| form | Powder |
| color | Off-white to beige |
| Water Solubility | Partly miscible in water. |
| Sensitive | Hygroscopic |
| InChI | 1S/C5H12N2.2ClH/c6-5-2-1-3-7-4-5;;/h5,7H,1-4,6H2;2*1H |
| InChIKey | GGPNYXIOFZLNKW-UHFFFAOYSA-N |
| SMILES | Cl.Cl.NC1CCCNC1 |
| CAS DataBase Reference | 138060-07-8(CAS DataBase Reference) |
| UNSPSC Code | 12352100 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
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|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P305+P351+P338-P280a-P304+P340-P405-P501a | |||||||||
| target organs | Respiratory system | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-37/39-36 | |||||||||
| WGK Germany | 3 | |||||||||
| Hazard Note | Irritant | |||||||||
| HS Code | 29333990 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
|||||||||
| NFPA 704 |
|
3-Aminopiperidine dihydrochloride price More Price(61)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| AstaTech | 51816 | 3-AMINOPIPERIDINE HCL 97% | 138060-07-8 | 1G | $23 | 2026-04-30 | Buy |
| AstaTech | 51816 | 3-AMINOPIPERIDINE HCL 97% | 138060-07-8 | 5G | $33 | 2026-04-30 | Buy |
| Apolloscientific | OR6131 | 3-Aminopiperidine dihydrochloride >97% | 138060-07-8 | 1g | $21 | 2026-06-04 | Buy |
| Apolloscientific | OR6131 | 3-Aminopiperidine dihydrochloride >97% | 138060-07-8 | 5g | $24 | 2026-06-04 | Buy |
| Apolloscientific | OR6131 | 3-Aminopiperidine dihydrochloride >97% | 138060-07-8 | 25g | $66 | 2026-06-04 | Buy |
3-Aminopiperidine dihydrochloride Chemical Properties, Uses, Production
Chemical Properties
Off-white to beige powder
Uses
Reactant for N-arylation of heterocyclic diamines Reactant for synthesis of substituted quinolones with reduced phototoxic risk
Uses
It is used as a reactant for N-arylation of heterocyclic diamines and for synthesis of substituted quinolones with reduced phototoxic risk.
Uses
Reactant for N-arylation of heterocyclic diamines
Reactant for synthesis of substituted quinolones with reduced phototoxic risk
General Description
Estimation of (S)-piperidin-3-amine in (R)-piperidin-3-amine dihydrochloride (3-aminopiperidine dihydrochloride) has been investigated by chiral high-performance liquid chromatographic (chiral HPLC) method.
Synthesis
689758-90-5
127294-75-1
The general procedure for the synthesis of 3-piperidinamine hydrochloride from piperidine-3-carbohydrazide was as follows: 36 g (250 mmol) of racemic piperidine carbohydrazide was added to 125 g of water under ice/salt bath cooling conditions, followed by the addition of 45 mL (500 mmol) of concentrated hydrochloric acid. Keeping the reaction temperature at 0 °C, 25.1 g of isoamyl nitrite (300 mmol) was slowly added over 30 min and stirring was continued at the same temperature for 30 min. The reaction was monitored by HPLC to confirm the complete conversion of piperidine carbohydrazide to the target azide and no starting material remained. The reaction mixture was poured dropwise into 500 mL of water preheated to 80 °C over 10 min and subsequently boiled for 60 min. Upon completion of the reaction, the solution was cooled to room temperature, 40 mL of concentrated hydrochloric acid was added and the solution was concentrated to a viscous state. The solution was again concentrated by adding 100 mL of water, followed by the addition of 100 mL of isopropanol and repeating the concentration process. The residue was dissolved in 50 mL of hot methanol and 100 g of acetone was added dropwise to the cooled methanol solution under vigorous stirring to induce precipitation of 3-aminopiperidine dihydrochloride (40 g of wet product). The product was dried with two portions (50 mL each) of isopropanol by azeotropic distillation under reduced pressure. The dried product was suspended in hot methanol and stirred overnight at room temperature. Subsequently, the suspension was diluted with 70 g of acetone and the solid product was separated by filtration. Finally 33.2 g (192 mmol, 77% yield) of 3-aminopiperidine dihydrochloride was obtained as a white powder. The product had a chemical purity of 98.7% by HPLC and a water content of 0.046% by Karl Fischer titration.
References
[1] Patent: WO2014/128139, 2014, A1. Location in patent: Page/Page column 33
3-Aminopiperidine dihydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Wanyue Biological Medicine Co., LTD | 17502177640 | 977963479@qq.com | China | 19 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| PharmaBlock Sciences (Nanjing),Inc. | 025-86918202 4000255188 | sales@pharmablock.com | China | 5000 | 55 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| INTATRADE GmbH | +49 3493/605464 | sales@intatrade.de | Germany | 3563 | 66 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| JinYan Chemicals(ShangHai) Co.,Ltd. | 13817811078 | sales@jingyan-chemical.com | China | 9963 | 60 |
| Sichuan Guanghan Bio-Tech Co., Ltd | +86-28-86127071 | info@sino-produce.com | China | 400 | 66 |
| Pure Chemistry Scientific Inc. | 001-857-928-2050 or 1-888-588-9418 | sales@chemreagents.com | United States | 10174 | 62 |
View Latest Price from 3-Aminopiperidine dihydrochloride manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-06-30 | 3-Aminopiperidine dihydrochloride
138060-07-8
|
1kg | 99% | 10000KGS | Shaanxi Dideu New Materials Co. Ltd | ||
 |
2021-07-13 | 3-Aminopiperidine dihydrochloride
138060-07-8
|
$10.00-15.00 | 1KG | 99%+ HPLC | Zhuozhou Wenxi import and Export Co., Ltd | ||
 |
2019-07-06 | 3-Aminopiperidine dihydrochloride
138060-07-8
|
$1.00 | 1KG | 98% | 1ton | Career Henan Chemical Co |
-
- 3-Aminopiperidine dihydrochloride
138060-07-8
- $0.00
- 99%
- Shaanxi Dideu New Materials Co. Ltd
-
- 3-Aminopiperidine dihydrochloride
138060-07-8
- $10.00-15.00
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
-
- 3-Aminopiperidine dihydrochloride
138060-07-8
- $1.00
- 98%
- Career Henan Chemical Co
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