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N-BOC-3-Aminopiperidine

N-BOC-3-Aminopiperidine structure

CAS No.: 184637-48-7

Chemical Name:: N-BOC-3-Aminopiperidine

Synonyms: TERT-BUTYL 3-AMINOPIPERIDINE-1-CARBOXYLATE;Azacycloheptane, 3-amino-1-t-butoxycarbonyl-;1-BOC-3-AMINOPIPERIDINE;N-BOC-3-AMinopiperid;3-AMINO-1-N-BOC-PIPERIDINE;3-Amino-1-Boc-piperidine,97%;N-BOC-3-Aminopiperidine USP/EP/BP;1-BOC-3-AMINOPIPERIDINE HYDROCHLORIDE;3-AMINO-1-TERTBUTOXYCARBONYL-PIPERIDINE;3-amino-1-piperidinecarboxylic acid tert-butyl ester

CBNumber:: CB0211321

Molecular Formula:: C10H20N2O2

Molecular Weight:: 200.28

MDL Number:: MFCD01861219

MOL File:: 184637-48-7.mol

MSDS File:: SDS

Last updated:2026-05-27 17:22:56

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N-BOC-3-Aminopiperidine Properties

Melting point	181-182°C
Boiling point	277.3±33.0 °C(Predicted)
Density	1.02
refractive index	1.4710-1.4750
storage temp.	under inert gas (nitrogen or Argon) at 2–8 °C
form	clear liquid
pka	10.35±0.20(Predicted)
color	Colorless to Light yellow
optical activity	Consistent with structure
Water Solubility	Slightly soluble in water.
Sensitive	Air Sensitive
InChI	InChI=1S/C10H20N2O2/c1-10(2,3)14-9(13)12-6-4-5-8(11)7-12/h8H,4-7,11H2,1-3H3
InChIKey	AKQXKEBCONUWCL-UHFFFAOYSA-N
SMILES	N1(C(OC(C)(C)C)=O)CCCC(N)C1
CAS DataBase Reference	184637-48-7(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H335

Precautionary statements

P261-P280a-P304+P340-P305+P351+P338-P405-P501a

Hazard Codes

Xn,Xi

Risk Statements

22-36/37/38-51

Safety Statements

26-39-37

HazardClass

IRRITANT

HS Code

29335990

NFPA 704

	0
2		0

N-BOC-3-Aminopiperidine price More Price(78)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TCI Chemical	A2314	3-Amino-1-tert-butoxycarbonylpiperidine >97.0%(GC)(T)	184637-48-7	1g	$27	2026-04-30	Buy
TCI Chemical	A2314	3-Amino-1-tert-butoxycarbonylpiperidine >97.0%(GC)(T)	184637-48-7	5g	$107	2026-04-30	Buy
Usbiological	263720	1-Boc-3-aminopiperidine Asreported	184637-48-7	1g	$333	2026-06-03	Buy
Usbiological	263720	1-Boc-3-aminopiperidine Asreported	184637-48-7	2g	$439	2026-06-03	Buy
Usbiological	263720	1-Boc-3-aminopiperidine Asreported	184637-48-7	5g	$559	2026-06-03	Buy

Product number	Packaging	Price	Buy
A2314	1g	$27	Buy
A2314	5g	$107	Buy
263720	1g	$333	Buy
263720	2g	$439	Buy
263720	5g	$559	Buy

N-BOC-3-Aminopiperidine Chemical Properties, Uses, Production

Uses

3-Amino-1-Boc-piperidine is used as an organic chemical synthesis intermediate.

Synthesis

54012-73-6

24424-99-5

144243-24-3

184637-48-7

In a 200 mL four-necked flask equipped with a stirrer, pH sensor, and two dropping funnels, 90 g of ethanol and 10.0 g (0.1 mol) of 3-aminopiperidine were added and stirred at 10 to 15 °C. 21.8 g (0.1 mol) di-tert-butyl dicarbonate was slowly added through one dropping funnel while 17.6 g (0.11 mol) 25% aqueous sodium hydroxide was added dropwise through the other dropping funnel, and the dropping rate was controlled to maintain the pH of the reaction system between 11.8 and 12.2. The titration process was completed in about 1 hour. Upon completion of the reaction, the composition of the reaction mixture was analyzed and confirmed to contain 6% unreacted 3-aminopiperidine, 91.5% of the target product 3-amino-1-tert-butoxycarbonylpiperidine and 1.1% of the by-product 3-tert-butoxycarbonylaminopiperidine.

References

[1] Patent: EP1460061, 2004, A1. Location in patent: Page 6-7

N-BOC-3-Aminopiperidine synthesis

Synthesis of N-BOC-3-Aminopiperidine from 1-Benzyl-3-N-Boc-aminopiperidine

N-BOC-3-Aminopiperidine Preparation Products And Raw materials

Raw materials

(9H-Fluoren-9-yl)methyl 3-((tert-butoxycarbonyl)amino)piperidine-1-carboxylate Benzyl 3-(tert-Butoxycarbonylamino)piperidine-1-carboxylate 3-(Boc-amino)pyridine 1-Benzyl-3-N-Boc-aminopiperidine 3-Aminopyridine

3-Aminopiperidine Di-tert-butyl dicarbonate Sodium hydroxide Ethanol DL-Glutamic acid

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Preparation Products

1-Boc-3-aminopiperidine 1-Benzyl-3-aminopiperidine 1-(Methylsulfonyl)-3-piperidinaMine Trifluoroacetate

N-BOC-3-Aminopiperidine Suppliers

Global Suppliers ( 287)

Supplier	Tel	Email	Country	ProdList	Advantage
Shaanxi Henghan New Materials Co., Ltd	15719109892	907967238@qq.com	China	2594	58
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	4006356688 18621169109	market03@meryer.com	China	40202	62
Alfa Aesar	400-6106006	saleschina@alfa-asia.com	China	30103	84
TCI (Shanghai) Development Co., Ltd.	021-67121386	Sales-CN@TCIchemicals.com	China	24512	81
Beijing HwrkChemical Technology Co., Ltd	89508211 18501085097	sales.bj@hwrkchemical.com	China	9407	55
Energy Chemical	400-0056266	sales8178@energy-chemical.com	China	44850	61
Wuhan Chemwish Technology Co., Ltd	86-027-67849912	sales@chemwish.com	China	35884	56
Capot Chemical Co., Ltd	+86 (0) 571 85 58 67 18		China	18187	66
Shanghai Sinch Parmaceuticals Tech. Co. Ltd.	+86-21-54098501	sales@sinch.com.cn	China	11592	64

Supplier	Advantage
Shaanxi Henghan New Materials Co., Ltd	58
J & K SCIENTIFIC LTD.	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	62
Alfa Aesar	84
TCI (Shanghai) Development Co., Ltd.	81
Beijing HwrkChemical Technology Co., Ltd	55
Energy Chemical	61
Wuhan Chemwish Technology Co., Ltd	56
Capot Chemical Co., Ltd	66
Shanghai Sinch Parmaceuticals Tech. Co. Ltd.	64

View Latest Price from N-BOC-3-Aminopiperidine manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2021-08-12	N-BOC-3-Aminopiperidine 184637-48-7	$10.00-15.00	1KG	99%+ HPLC		Zhuozhou Wenxi import and Export Co., Ltd
2021-07-02	3-Amino-1-tert-butoxycarbonylpiperidine 184637-48-7	$10.00-15.00	1KG	99%+ HPLC		Zhuozhou Wenxi import and Export Co., Ltd
2019-07-06	N-BOC-3-Aminopiperidine 184637-48-7	$1.00	1KG	98%	500kg	Career Henan Chemical Co

N-BOC-3-Aminopiperidine
184637-48-7
$10.00-15.00
99%+ HPLC
Zhuozhou Wenxi import and Export Co., Ltd

3-Amino-1-tert-butoxycarbonylpiperidine
184637-48-7
$10.00-15.00
99%+ HPLC
Zhuozhou Wenxi import and Export Co., Ltd

N-BOC-3-Aminopiperidine
184637-48-7
$1.00
98%
Career Henan Chemical Co

N-BOC-3-Aminopiperidine Spectrum

N-BOC-3-Aminopiperidine(184637-48-7)¹HNMR

184637-48-7 (N-BOC-3-Aminopiperidine) Related Search:

Haloperidol Cyhalofop-butyl Butyl acetate 1-Aminopiperidine 4-Amino-1-Boc-piperidine

Tris(trimethylsilyl)phosphate 6-Aminocaproic acid tert-Butyl peroxyacetate 3-Aminopyridine Diethylene glycol monobutyl ether

Buprofezin Tris(hydroxymethyl)aminomethane Glycine tert-Butanol Aminoethoxyvinyl glycine hydrochloride

Butyl oleate N-Boc-1,2,3,6-tetrahydropyridine N-Boc-4-iodopiperidine

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3-AMINO-1-BOC-PIPERIDINE X HCL N-Boc-3-piperidinamine 1-Boc-3-aminopiperidinecitricacid 1-BOC-3-aminopiperdine 1-Boc-3-aminopiperidine ,97% N-BOC-3-AMinopiperidine(HCl) N-BOC-3-AMinopiperid 3-Amino-1-Boc-piperidine tert-Butyl 3-Amino-1-piperidinecarboxylate 3-Amino-1-piperidinecarboxylic Acid tert-Butyl Ester 3(R)-[(tert-butoxycarbonyl)-aMino]piperidine tert-Butyl 3-aminopiperidine-1-carboxylate, 3-Amino-1-(tert-butoxycarbonyl)piperidine 3-amino-1-piperidinecarboxylic acid tert-butyl ester 3-Amino-1-Boc-piperidine,97% N-1-BOC-3-AMINOPIPERIDINE N-BOC-3-AMINOPIPERIDINE DL-3-AMINO-1-N-BOC-PIPERIDINE (+/-)-1-BOC-3-AMINO-PIPERIDINE 1-BOC-3-AMINOPIPERIDINE 1-BOC-3-AMINOPIPERIDINE CITRIC ACID SALT 1-N-BOC-3-AMINOPIPERIDINE 1-PIPERIDINECARBOXYLIC ACID, 3-AMINO-, 1,1-DIMETHYLETHYL ESTER 3-AMINOPIPERIDINE, 1-BOC PROTECTED HYDROCHLORIDE 3-AMINO-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER 3-AMINOPIPERIDINE, N1-BOC PROTECTED 3-AMINO-1-TERT-BUTOXYCARBONYL-PIPERIDINE HCL 3-AMINO-1-TERT-BUTOXYCARBONYL-PIPERIDINE HYDROCHLORIDE 3-AMINO-1-TERTBUTOXYCARBONYL-PIPERIDINE (+/-)-3-AMINO-1-BOC-PIPERIDINE 3-AMINO-1-BOC-PIPERIDINE HCL (+/-)-3-AMINO-1-N-BOC-PIPERIDINE 3-AMINO-1-N-BOC-PIPERIDINE (+/-)-3-AMINO-1-N-BOC-PIPERIDINE HYDROCHLORIDE 3-AMINO-1-N-BOC-PIPERIDINE HYDROCHLORIDE 3-AMINO-4-BOC-PIPERIDINE 1-Boc-3-amniopiperidine 3-Aminopiperidine, N1-BOC protected 97% Boc-3-Aminopiperidine dihydrochloride 1-Piperidinecarboxylicacid,3-amino-,1,1-dimethylethylester(9CI) 1-BOC-3-AMINOPIPERIDINE HYDROCHLORIDE 1-BOC-3-AMINOPIPERIDINE / 3-AMINO-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER 3-AMINO-1-BOC-PIPERIDINE X HCL, 3-AMINO-1-TERT-BUTOXYCARBONYL-PIPERIDINE X HCL >98% 3-Amino-1-tert-butoxycarbonylpiperidine > Linagliptin Impurity 102 Alogliptin Impurity 80 (+/-)-3-Amino-1-n-boc-piperidine citric acid salt ert-Butyl3-aminopiperidine-1-carboxylate tert-Butyl 3-Amino-1-piperidinecarboxylate N-BOC-3-Aminopiperidine USP/EP/BP 1-Piperidinecarboxylic acid, 3-amino-, 1,1-dimethylethyl ester (9CI, ACI) 3-amino-1-Piperidinecarboxylic acid 1,1-dimethylethyl ester (9CI ACI) N -B0C-3- Aminopiperidine CAS:184637-48-7 Azacycloheptane, 3-amino-1-t-butoxycarbonyl- TERT-BUTYL 3-AMINOPIPERIDINE-1-CARBOXYLATE 184637-48-7 C10H20N2O2xHCl C10H20N2O2C6H8O7 Piperidines Chiral Reagent