5-Formylsalicylic acid
- CAS No.
- 616-76-2
- Chemical Name:
- 5-Formylsalicylic acid
- Synonyms
- 5-FORMYL-2-HYDROXYBENZOIC ACID;5-FORMYLSALICYLIC ACID;5-FormylsalicylicAcid>5-FORMYLSALICYLIC ACID 97%;5-formyl-2-hydroxybenzoate;5-Formylsalicylic acid,97%;5-Formylsalicylic acid ,98%;2-HYDROXY-5-FORMYLBENZOIC ACID;3-Carboxy-4-hydroxybenzaldehyde;6-Hydroxyisophthalaldehydic acid
- CBNumber:
- CB7214073
- Molecular Formula:
- C8H6O4
- Molecular Weight:
- 166.13
- MDL Number:
- MFCD00006945
- MOL File:
- 616-76-2.mol
- MSDS File:
- SDS
| Melting point | 250 °C (dec.) (lit.) |
|---|---|
| Boiling point | 214.32°C (rough estimate) |
| Density | 1.2208 (rough estimate) |
| refractive index | 1.4611 (estimate) |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| form | powder |
| pka | 2.67±0.10(Predicted) |
| color | brownish-yellow |
| BRN | 2640881 |
| Stability | Hygroscopic |
| InChI | InChI=1S/C8H6O4/c9-4-5-1-2-7(10)6(3-5)8(11)12/h1-4,10H,(H,11,12) |
| InChIKey | UTCFOFWMEPQCSR-UHFFFAOYSA-N |
| SMILES | C(O)(=O)C1=CC(C=O)=CC=C1O |
| CAS DataBase Reference | 616-76-2(CAS DataBase Reference) |
| FDA UNII | 23V3W745T8 |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H317-H319 |
| Precautionary statements | P261-P264-P280-P301+P312-P302+P352-P305+P351+P338 |
| PPE | Eyeshields, Gloves, type N95 (US) |
| Risk Statements | 36/37/38 |
| Safety Statements | 22-24/25 |
| WGK Germany | 3 |
| HS Code | 29189900 |
| Storage Class | 11 - Combustible Solids |
| Hazard Classifications | Acute Tox. 4 Oral Eye Irrit. 2 Skin Irrit. 2 Skin Sens. 1 |
5-Formylsalicylic acid price More Price(57)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | F0400 | 5-Formylsalicylic Acid >98.0%(HPLC)(T) | 616-76-2 | 5g | $28 | 2026-04-30 | Buy |
| TCI Chemical | F0400 | 5-Formylsalicylic Acid >98.0%(HPLC)(T) | 616-76-2 | 25g | $85 | 2026-04-30 | Buy |
| TRC | TRC-F701093-500MG | 5-Formylsalicylic Acid | 616-76-2 | 500mg | $70 | 2026-06-03 | Buy |
| Biosynth | FF35041 | 5-Formylsalicylic acid | 616-76-2 | 50g | $181 | 2026-06-04 | Buy |
| Biosynth | FF35041 | 5-Formylsalicylic acid | 616-76-2 | 100g | $273 | 2026-06-04 | Buy |
5-Formylsalicylic acid Chemical Properties, Uses, Production
Chemical Properties
light beige fine crystalline powder
Uses
5-Formylsalicylic Acid is used as a selective phase for the extraction of iron(III) in silica gel. It is also used in preparation of styrylquinolines as potent HIV-1 integrase inhibitors that block HIV-1 replication in CEM cells.
Definition
ChEBI: 5-formylsalicylic acid is a monohydroxybenzoic acid in which a benzoic acid nucleus is substituted at positions 2 and 5 by a formyl group and an hydroxy group respectively. It is a member of benzaldehydes, a monohydroxybenzoic acid and a member of phenols. It is functionally related to a salicylic acid.
Synthesis
89-56-5
616-76-2
General procedure for the synthesis of 5-formyl-2-hydroxybenzoic acid from 5-methylsalicylic acid: a mixture of the substrate 5-methylsalicylic acid (1 mmol), cobalt salt (n1 mol%), and NaOH (n2 eq.) in ethylene glycol (5 mL) was reacted with oxygen (1 atm) with stirring for 8 hours at 80 °C. Upon completion of the reaction, hydrochloric acid (10 mL, 2%) and methyl tert-butyl ether (MTBE, 10 mL) were added sequentially to the reaction mixture. The organic layer was separated and the aqueous phase was further extracted with MTBE (10 mL x 2). The organic phases were combined, dried with anhydrous sodium sulfate and concentrated to give the residue. The residue was purified by silica gel column chromatography (eluent: petroleum ether/ethyl acetate, 10/1) to afford the target product 5-formyl-2-hydroxybenzoic acid.
References
[1] Tetrahedron Letters, 2014, vol. 55, # 8, p. 1406 - 1411
[2] Molecular Catalysis, 2018, vol. 453, p. 121 - 131
5-Formylsalicylic acid Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hubei Zhuosheng New Material Technology Co., Ltd | 18971238634 | 2189484023@qq.com | China | 497 | 58 |
| Taizhou Tongxin Bio-Tech Co., Ltd | 0523-86818997 18652728585 | sales@allyrise.com | China | 2986 | 60 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| Chemexcel (Zhangjiakou) Fine Chemicals Co., Ltd | 86-10-62944695-809 | sales@chemexcel.com.cn | China | 80 | 62 |
| TAIYUAN RHF CO.,LTD. | +86 351 7031519 | sales@RHFChem.com | China | 2334 | 56 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Shijiazhuang Sdyano Fine Chemical Co., Ltd. | 0311-89250318 13582355795 | master@sjzsdyn.com | China | 2776 | 65 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 |
View Latest Price from 5-Formylsalicylic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-04-04 | 5-Formylsalicylic acid
616-76-2
|
1kg | 98% | 1Ton | Henan Aochuang Chemical Co.,Ltd. | ||
 |
2021-07-02 | 5-Formylsalicylic acid
616-76-2
|
$10.00-15.00 | 1KG | 99%+ HPLC | Zhuozhou Wenxi import and Export Co., Ltd | ||
 |
2020-09-15 | 5-Formylsalicylic acid
616-76-2
|
$150.00 | 1KG | 99.9% | 20tons | Hebei Runbin Biotechnology Co. LTD |
-
- 5-Formylsalicylic acid
616-76-2
- 98%
- Henan Aochuang Chemical Co.,Ltd.
-
- 5-Formylsalicylic acid
616-76-2
- $10.00-15.00
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
-
- 5-Formylsalicylic acid
616-76-2
- $150.00
- 99.9%
- Hebei Runbin Biotechnology Co. LTD
