4-Hydroxyphenyloxoacetic acid methyl ester
- CAS No.
- 38250-16-7
- Chemical Name:
- 4-Hydroxyphenyloxoacetic acid methyl ester
- Synonyms
- Methyl 2-(4-hydroxyphenyl)-2-oxoacetate;Methyl 4-hydroxy-α-oxobenzeneacetate;4-Hydroxyphenyloxoacetic acid methyl ester;4-Hydroxy-α-oxobenzeneacetic acid methyl ester;Benzeneacetic acid, 4-hydroxy-α-oxo-, methyl ester
- CBNumber:
- CB72236664
- Molecular Formula:
- C9H8O4
- Molecular Weight:
- 180.16
- MDL Number:
- MFCD24713493
- MOL File:
- 38250-16-7.mol
- MSDS File:
- SDS
| storage temp. | Inert atmosphere,Room Temperature |
|---|---|
| Appearance | White to off-white Solid |
| EPA Substance Registry System | Benzeneacetic acid, 4-hydroxy-.alpha.-oxo-, methyl ester (38250-16-7) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P280-P301+P312-P302+P352-P305+P351+P338 |
| TSCA | TSCA listed |
4-Hydroxyphenyloxoacetic acid methyl ester price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Activate Scientific | AS141537 | Methyl 2-(4-hydroxyphenyl)-2-oxoacetate 97% | 38250-16-7 | 1g | $143 | 2026-06-04 | Buy |
| Activate Scientific | AS141537 | Methyl 2-(4-hydroxyphenyl)-2-oxoacetate 97% | 38250-16-7 | 5g | $562 | 2026-06-04 | Buy |
| Synthonix | M51644 | Methyl 2-(4-hydroxyphenyl)-2-oxoacetate 95+% | 38250-16-7 | 1g | $120 | 2026-05-06 | Buy |
| Synthonix | M51644 | Methyl 2-(4-hydroxyphenyl)-2-oxoacetate 95+% | 38250-16-7 | 5g | $470 | 2026-05-06 | Buy |
| aablocks | AA00395K | Methyl 2-(4-hydroxyphenyl)-2-oxoacetate ≥95% | 38250-16-7 | 250mg | $37 | 2026-05-28 | Buy |
4-Hydroxyphenyloxoacetic acid methyl ester Chemical Properties, Uses, Production
Synthesis
37763-23-8
38250-16-7
Step 1: (R)-2-Amino-2-(4-hydroxyphenyl)acetic acid (D-4-hydroxyphenylglycine, 10.0 g, 60.1 mmol) was dissolved in methanol (200 mL) and thionyl chloride (8 mL) was added slowly and dropwise. The reaction mixture was stirred at room temperature for 10 hours. After completion of the reaction, the solvent was removed by vacuum concentration and the residue was washed twice with ether to afford methyl (R)-2-amino-2-(4-hydroxyphenyl)acetate (D-4-hydroxyphenylglycine methyl ester, 13.0 g, 60.0 mmol, 100% yield) as a white solid.1H NMR (300 MHz, DMSO-d6) δ 3.68 (s, 3H) 5.07 (s, 1H), 6.85 (d, J=8.5Hz, 2H), 7.29 (d, J=8.6Hz, 2H), 9.03 (s, 3H), 10.02 (s, 1H). Step 2: Methyl (R)-2-amino-2-(4-hydroxyphenyl)acetate (D-4-hydroxyphenylglycine methyl ester, 0.302 g, 1.39 mmol) was dissolved in freshly prepared glyoxalic acid (1.27 g, 13.8 mmol) and copper(II) sulfate pentahydrate (0.35 g, 1.40 mmol) in 2.5 M pyridine buffer and 0.5 M acetic acid in an aqueous solution. The reaction mixture was stirred at room temperature for 10 hours. Upon completion of the reaction, it was extracted with dichloromethane (10 mL x 3), the organic layers were combined, washed with 0.5 M HCl (20 mL x 3), dried, filtered and concentrated in vacuum. The residue was purified by flash column (silica gel, chloroform elution) to afford methyl 2-(4-hydroxyphenyl)-2-oxoacetate (0.109 g, 6.06 mmol, 44% yield) as a clear oil.1H NMR (300 MHz, CDCl3) δ 3.99 (s, 3H), 5.41 (br s, 1H), 6.95 (d, J=8.8 Hz, 2H), 8.00 (d, J=8.8Hz, 2H).
References
[1] Journal of Medicinal Chemistry, 2002, vol. 45, # 18, p. 3946 - 3952
[2] Patent: WO2013/33093, 2013, A1. Location in patent: Page/Page column 137; 138
4-Hydroxyphenyloxoacetic acid methyl ester Preparation Products And Raw materials
Raw materials
Preparation Products
4-Hydroxyphenyloxoacetic acid methyl ester Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Tianjin Derchemist Science & Technology Co., Ltd. | 22-58627059 13920586291 | zdcomcon@126.com | China | 4094 | 50 |
| Shanghai Raise Chemical Technology Co.,Ltd | 15026594951 | rs@raise-chem.com | China | 4905 | 55 |
| Zhengzhou HSH Science & Technology Co., Ltd. | 0371-55932928 18937192232; | 1282296214@qq.com | China | 497 | 55 |
| Shanghai ChuangYan Chemical Technology Co., Ltd. | 021-11111111 11111111111 | 546919421@qq.com | China | 3770 | 55 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
| BePharm Ltd | 400-685-9117 | market@bepharm.com | China | 15081 | 60 |
| Yantai ShengKailun Chemical Technology Co., Ltd. | 13356901049 | 3119594100@qq.com | China | 7964 | 55 |
| Amatek Scientific Co. Ltd. | 0512-56316828 400-867-5858;400-867-5858 | info@amateksci.com | China | 28760 | 58 |
| Aikon International Limited | 025-58859352 13913916777 | dt3@aikonchem.com | China | 15490 | 58 |
| Fan De(Beijing) Biotechnology Co., Ltd. | 15911056312 | liming@bio-fount.com | China | 9718 | 58 |
