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Fmoc-Nle-OH

Fmoc-Nle-OH structure

CAS No.: 77284-32-3

Chemical Name:: Fmoc-Nle-OH

Synonyms: FMOC-NLE;FMOC-L-NLE-OH;FMOC-NORLEUCINE;FMOC-L-NORLEUCINE;Fmoc-Nle-OH;FMOC-AHX(2)-OH;FMOC-ACPO(2)-OH;FMOC-NLE-OH 98+%;RARECHEM EM WB 0166;N-FMOC-L-NORLEUCINE

CBNumber:: CB7225457

Molecular Formula:: C21H23NO4

Molecular Weight:: 353.41

MDL Number:: MFCD00037537

MOL File:: 77284-32-3.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-09-12 18:54:48

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Fmoc-Nle-OH Properties

Melting point	141-144 °C(lit.)
alpha	-18.5 º (C=1 IN DMF)
Boiling point	565.6±33.0 °C(Predicted)
Density	1.209±0.06 g/cm3(Predicted)
storage temp.	2-8°C
solubility	Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
pka	3.91±0.21(Predicted)
form	Crystalline Powder
color	White to off-white
optical activity	[α]20/D 18±1°, c = 1% in DMF
BRN	5305164
Major Application	peptide synthesis
InChI	1S/C21H23NO4/c1-2-3-12-19(20(23)24)22-21(25)26-13-18-16-10-6-4-8-14(16)15-9-5-7-11-17(15)18/h4-11,18-19H,2-3,12-13H2,1H3,(H,22,25)(H,23,24)/t19-/m0/s1
InChIKey	VCFCFPNRQDANPN-IBGZPJMESA-N
SMILES	CCCC[C@H](NC(=O)OCC1c2ccccc2-c3ccccc13)C(O)=O
CAS DataBase Reference	77284-32-3(CAS DataBase Reference)
UNSPSC Code	12352209
NACRES	NA.26

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H335

Precautionary statements

P261-P264b-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P362+P364-P403+P233-P501c

PPE

Eyeshields, Gloves, type N95 (US)

Safety Statements

22-24/25

WGK Germany

HS Code

2924 29 70

HazardClass

IRRITANT

Storage Class

13 - Non Combustible Solids

NFPA 704

	1
2		0

Fmoc-Nle-OH price More Price(92)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	8.52014	Fmoc-Nle-OH Novabiochem?	77284-32-3	5G	$102	2026-04-30	Buy
Sigma-Aldrich	8.52014	Fmoc-Nle-OH Novabiochem?	77284-32-3	25g	$383	2026-04-30	Buy
Sigma-Aldrich	8.52014	Fmoc-Nle-OH Novabiochem^®	77284-32-3	100 g	$1190	2026-04-30	Buy
Sigma-Aldrich	8.52014	Fmoc-Nle-OH Novabiochem^®	77284-32-3	1 kg	$10790	2026-04-30	Buy
Sigma-Aldrich	47692	Fmoc-Nle-OH ≥98.0% (sum of enantiomers, HPLC)	77284-32-3	1g	$56	2023-06-20	Buy

Product number	Packaging	Price	Buy
8.52014	5G	$102	Buy
8.52014	25g	$383	Buy
8.52014	100 g	$1190	Buy
8.52014	1 kg	$10790	Buy
47692	1g	$56	Buy

Fmoc-Nle-OH Chemical Properties, Uses, Production

Chemical Properties

White crystalline

Uses

Fmoc-Nle-OH, is an amino acid derivative used in chemical synthesis and peptide chemistry.

reaction suitability

reaction type: Fmoc solid-phase peptide synthesis

Synthesis

4-Hexenoic acid, 2-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]-, (2S)-

947154-63-4

77284-32-3

V-Fmoc allylglycine (100 mg, 0.296 mmol), degassed dichloromethane (6.0 mL), terminal olefins (1.48 mmol, 5 eq.), and HGII catalyst (9.29 mg, 5 mol%) were added to a Schlenk reaction flask equipped with a magnetic stirring bar in a drying oven under nitrogen atmosphere. After sealing the reaction flask, it was removed from the desiccator and connected to a vacuum system. The reaction vial was placed under a stream of nitrogen and the quick assembly stopper was replaced with a sub-seal with a 26-gauge pinhole to ensure a continuous flow of nitrogen across the top of the reaction system. The reaction mixture was stirred overnight at room temperature, followed by evaporation of all dichloromethane. The residue was washed with hexane (2 x 10 mL) and collected by filtration or centrifugation. The resulting residue was redissolved in methanol (10 mL) and transferred to a Fischer-Porter reaction tube. The reaction tube was filled with hydrogen (60 psi), sealed and stirred overnight at room temperature. Upon completion of the reaction, the mixture was concentrated under vacuum and the residual brown solid was purified by column chromatography to give the pure Fmoc amino acid analog. Alternatively, the residual brown solid is dissolved in a small amount of ether, the insoluble material is removed by filtration, and the filtrate is concentrated under vacuum to give an off-white solid.

References

[1] Journal of Peptide Science, 2013, vol. 19, # 8, p. 470 - 476
[2] Patent: WO2014/5197, 2014, A1. Location in patent: Page/Page column 48-49

Fmoc-Nle-OH synthesis

Synthesis of Fmoc-Nle-OH from L-Norleucine and 9-Fluorenylmethyl chloroformate

Fmoc-Nle-OH Preparation Products And Raw materials

Raw materials

L-Norleucine Fmoc-D-Nle-OH DL-Norleucine 4-Hexenoic acid, 2-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]-, (2S)- 9-Fluorenylmethyl chloroformate

Hydrogen Methanol

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Preparation Products

Fmoc-Nle-OH Suppliers

Global Suppliers ( 288)

Supplier	Tel	Email	Country	ProdList	Advantage
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	4006356688 18621169109	market03@meryer.com	China	40202	62
INTATRADE GmbH	+49 3493/605464	sales@intatrade.de	Germany	3563	66
Alfa Aesar	400-6106006	saleschina@alfa-asia.com	China	30103	84
Energy Chemical	400-0056266	sales8178@energy-chemical.com	China	44850	61
Wuhan Chemwish Technology Co., Ltd	86-027-67849912	sales@chemwish.com	China	35884	56
GL Biochem (Shanghai) Ltd	21-61263452 13641803416	ymbetter@glbiochem.com	China	9981	64
Capot Chemical Co., Ltd	+86 (0) 571 85 58 67 18		China	18187	66
Beijing Ouhe Technology Co., Ltd	13552068683 13522913783	2355560935@qq.com	China	11777	60
Shanghai Hanhong Scientific Co.,Ltd.	021-54306202 13764082696	info@hanhongsci.com	China	42917	64

Supplier	Advantage
J & K SCIENTIFIC LTD.	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	62
INTATRADE GmbH	66
Alfa Aesar	84
Energy Chemical	61
Wuhan Chemwish Technology Co., Ltd	56
GL Biochem (Shanghai) Ltd	64
Capot Chemical Co., Ltd	66
Beijing Ouhe Technology Co., Ltd	60
Shanghai Hanhong Scientific Co.,Ltd.	64

View Latest Price from Fmoc-Nle-OH manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2019-07-06	FMOC-NLE-OH 77284-32-3	$1.00	1KG	99%	20kg	Career Henan Chemical Co
	2019-07-06	FMOC-NLE-OH 77284-32-3	$1.00	1KG	99%	20kg	Career Henan Chemical Co

FMOC-NLE-OH
77284-32-3
$1.00
99%
Career Henan Chemical Co

FMOC-NLE-OH
77284-32-3
$1.00
99%
Career Henan Chemical Co

77284-32-3 (Fmoc-Nle-OH) Related Search:

9-Fluorenylmethyl carbamate L-Fmoc-Aspartic acid alpha-tert-butyl ester Fmoc-O-tert-butyl-D-threonine Fmoc-S-acetamidomethyl-L-cysteine Fmoc-L-aspartic acid 4-benzyl ester

N-FMoc-L-norvaline Fmoc-D-Asp(OtBu)-OH Fmoc-THr(Bzl)-OH Fmoc-L-homophenylalanine Fmoc-D-Cha-OH

Fmoc-sarcosine monohydrate Fmoc-Chg-OH Fmoc-Cha-OH Fmoc-D-Nle-OH Fmoc-D-4-iodophenylalanine

Fmoc-6-aminohexanoic acid Fmoc-HomoArg-OH Fmoc-Asp(ochex)-OH

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N-(9-Fluorenylmethoxycarbonyl)-Lnorleucine, Fmoc-L-norleucine Fmoc-Nle-OH >=98.0% (sum of enantiomers, HPLC) (9H-Fluoren-9-yl)MethOxy]Carbonyl L-Nle-OH Fmoc-L-norleucine≥ 99% (HPLC) (S)-2-(9H-FLUOREN-9-YLMETHOXYCARBONYLAMINO)-HEXANOIC ACID (S)-2-(FMOC-AMINO)HEXANOIC ACID (S)-2-(FMOC-AMINO)CAPROIC ACID (S)-N-ALPHA-FMOC-2-AMINOHEXANOIC ACID RARECHEM EM WB 0166 N-ALPHA-FMOC-L-NORLEUCINE N-ALPHA-(9-FLUORENYLMETHYLOXYCARBONYL)-L-NORLEUCINE N-ALPHA-(9-FLUORENYLMETHOXYCARBONYL)-L-NORLEUCINE N-ALPHA-(9-FLUORENYLMETHOXYCARBONYL)-L-2-AMINOCAPROIC ACID N-(9-FLUORENYLMETHOXYCARBONYL)-L-NORLEUCINE N-FMOC-L-NORLEUCINE N-(9-FLUORENYLMETHOXYCARBONYL)-L- & FMOC-NLE-OH 98+% N-ALPHA-(9-FLUORENYLMETHYLOXYCARBONYL)-L-NORLEUCINE, (S)-N-ALPHA-FMOC-2-AMINOHEXANOIC ACID FMOC-L-2-AMINOCAPROIC ACID FMOC-L-2-AMINOHEXANOIC ACID FMOC-L-NHCH[CH3(CH2)3]-COOH FMOC-ACPO(2)-OH FMOC-AHX(2)-OH Fmoc-Nle-OH (Fmoc-L-norleucine FMOC-L-NORLEUCINE extrapure (9-fluorenylmethoxycarbonyl)-L-norleucine-OH (S)-2-(Fmoc-amino)caproic acid, (S)-2-(Fmoc-amino)hexanoic acid, N-(9-Fluorenylmethoxycarbonyl)-L-norleucine, Fmoc-L-norleucine (2S)-2-(9H-Fluoren-9-ylmethoxycarbonylamino)hexanoic acid Fmoc-(S)-2-aminohexanoicacid 2-[[9H-fluoren-9-ylmethoxy(oxo)methyl]amino]hexanoate L-Norleucine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]- FMOC-NLE-OH USP/EP/BP (2R)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)hexanoate Fmoc-L-2-aminocaproic acid - 10 g Fmoc-Nle-OH,?97%min FMOC-L-NORLEUCINE FMOC-L-NLE-OH FMOC-NORLEUCINE FMOC-NLE Fmoc-Nle-OH 77284-32-3 Norleucine Peptide Synthesis Specialty Synthesis Unnatural Amino Acid Derivatives Unusual Amino Acids Amino Acid Derivatives Amino Acids