Fmoc-6-aminohexanoic acid
- CAS No.
- 88574-06-5
- Chemical Name:
- Fmoc-6-aminohexanoic acid
- Synonyms
- FMOC-ACP-OH;FMOC-6-AHX-OH;FMOC-EPSILON-AHX-OH;FMOC-6-AMINOCAPROIC ACID;FMoc-ε- AMinocaproic acid FMoc-ε- AMinocaproic acid;Fmoc-6-Aca;Fmoc-6-Ahx;FMOC-6-ACA-OH;Fmoc-e-Acp-OH;FMOC-ACP(6)-OH
- CBNumber:
- CB7388293
- Molecular Formula:
- C21H23NO4
- Molecular Weight:
- 353.41
- MDL Number:
- MFCD00077045
- MOL File:
- 88574-06-5.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 114 °C |
|---|---|
| Boiling point | 582.7±33.0 °C(Predicted) |
| Density | 1.210±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | Soluble in water or 1% acetic acid |
| form | Powder |
| pka | 4.75±0.10(Predicted) |
| color | White |
| Water Solubility | Soluble in 1% acetic acid, water and 1mmol in 2mL DMF clearly soluble. |
| BRN | 5883220 |
| Major Application | peptide synthesis |
| InChI | 1S/C21H23NO4/c23-20(24)12-2-1-7-13-22-21(25)26-14-19-17-10-5-3-8-15(17)16-9-4-6-11-18(16)19/h3-6,8-11,19H,1-2,7,12-14H2,(H,22,25)(H,23,24) |
| InChIKey | FPCPONSZWYDXRD-UHFFFAOYSA-N |
| SMILES | OC(=O)CCCCCNC(=O)OCC1c2ccccc2-c3ccccc13 |
| CAS DataBase Reference | 88574-06-5(CAS DataBase Reference) |
| UNSPSC Code | 12352209 |
| NACRES | NA.26 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26 | |||||||||
| WGK Germany | 3 | |||||||||
| HS Code | 2924 29 70 | |||||||||
| HazardClass | IRRITANT | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| NFPA 704 |
|
Fmoc-6-aminohexanoic acid price More Price(92)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 8.52053 | Fmoc-ε-Ahx-OH Novabiochem? | 88574-06-5 | 1g | $51.3 | 2026-04-30 | Buy |
| Sigma-Aldrich | 8.52053 | Fmoc-ε-Ahx-OH Novabiochem? | 88574-06-5 | 5G | $185 | 2026-04-30 | Buy |
| Sigma-Aldrich | 8.52053 | Fmoc-ε-Ahx-OH Novabiochem? | 88574-06-5 | 25g | $730 | 2026-04-30 | Buy |
| Sigma-Aldrich | 04067 | Fmoc-6-Ahx-OH ≥97.0% (HPLC) | 88574-06-5 | 1g | $123 | 2026-04-30 | Buy |
| Sigma-Aldrich | 04067 | Fmoc-6-Ahx-OH ≥97.0% (HPLC) | 88574-06-5 | 5g | $174 | 2026-04-30 | Buy |
Fmoc-6-aminohexanoic acid Chemical Properties,Uses,Production
Description
Fmoc-6-aminohexanoic acid can be used as a PROTAC linker in the synthesis of PROTACs and other conjugation applications. Fmoc-6-aminohexanoic acid is an alkane chian with terminal Fmoc-protected amine and carboxylic acid groups. The Fmoc group can be deprotected under basic condition to obtain the free amine which can be used for further conjugations. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.
Chemical Properties
White powder
Uses
Fmoc-6-aminohexanoic acid, is an amino acid derivative used in chemical synthesis and peptide chemistry.
reaction suitability
reaction type: Fmoc solid-phase peptide synthesis
Synthesis
82911-69-1
60-32-2
88574-06-5
GENERAL STEPS: 389 mg (2.96 mmol) of 6-aminohexanoic acid was dissolved in 20 mL of a solvent mixture of acetone/water (1:1, v/v), 1.00 g (2.96 mmol) of 9-fluorenylmethyl-N-succinimidyl carbonate (FmocOSuc) and 250 mg (2.96 mmol) of sodium bicarbonate (NaHCO3) were added. The reaction suspension was stirred at room temperature for 3 hours. After completion of the reaction, acetone was removed by distillation under reduced pressure and 20 mL of dichloromethane (DCM) was added to the residue. Insoluble solids were removed by filtration. The organic phase was washed sequentially with 10 mL of 0.1 M hydrochloric acid (HCl) and 10 mL of water. The washed organic phase was dried with anhydrous sodium sulfate (Na2SO4), concentrated under reduced pressure to remove the solvent, and the residue was dried under vacuum to give 747 mg (71% yield) of the target product Fmoc-6-aminohexanoic acid as a colorless solid.
References
[1] Organic and Biomolecular Chemistry, 2018, vol. 16, # 39, p. 7139 - 7142
[2] Helvetica Chimica Acta, 1997, vol. 80, # 4, p. 1061 - 1072
[3] Beilstein Journal of Organic Chemistry, 2015, vol. 11, p. 493 - 498
[4] Bioconjugate Chemistry, 2018, vol. 29, # 9, p. 2909 - 2919
[5] Analytical Chemistry, 2005, vol. 77, # 10, p. 3301 - 3308
Fmoc-6-aminohexanoic acid Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Nanjing Derno Pharmaceutical Technology Co., Ltd. | 02585057128;025-86957866 13952093866 | sales@dernopharm.com | China | 944 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| GL Biochem (Shanghai) Ltd | 21-61263452 13641803416 | ymbetter@glbiochem.com | China | 9981 | 64 |
| Beijing Ouhe Technology Co., Ltd | 13552068683 13522913783 | 2355560935@qq.com | China | 11777 | 60 |
| Jia Xing Isenchem Co.,Ltd | 0573-85285100 18627885956 | isenchem@163.com | China | 9389 | 66 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
View Lastest Price from Fmoc-6-aminohexanoic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-13 | FMOC-6-AMINOHEXANOIC ACID
88574-06-5
|
1KG | 98% | 2000 | Shenzhen Nexcon Pharmatechs Ltd. | ||
 |
2026-08-08 | Fmoc-6-Aminohexanoic acid
88574-06-5
|
1Box | 99% | 200kg | Hangzhou ICH Biofarm Co., Ltd | ||
 |
2019-07-06 | FMOC-6-AMINOHEXANOIC ACID
88574-06-5
|
$1.00 | 1KG | 99% | 20kg | Career Henan Chemical Co |
-
- FMOC-6-AMINOHEXANOIC ACID
88574-06-5
- 98%
- Shenzhen Nexcon Pharmatechs Ltd.
-
- Fmoc-6-Aminohexanoic acid
88574-06-5
- $0.00
- 99%
- Hangzhou ICH Biofarm Co., Ltd
-
- FMOC-6-AMINOHEXANOIC ACID
88574-06-5
- $1.00
- 99%
- Career Henan Chemical Co
