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(1S,2S)-N,N'-Dimethyl-1,2-cyclohexanediamine

(1S,2S)-N,N'-Dimethyl-1,2-cyclohexanediamine structure

CAS No.: 87583-89-9

Chemical Name:: (1S,2S)-N,N'-Dimethyl-1,2-cyclohexanediamine

Synonyms: Dimethylcyclohexanediamine;2S)-N;(S,S)-(+)-N,N;N\'-BisMethyl-1;ohexane-1,2-diamine;(1S,2S)-(+)-N,N'2-cyclohexane-diaMine;(1S,2S)-(+)-N,N'-DimethyL;(1S,2S)-N,N'-Dimethyl-1,2-cyc;N,N'-Dimethyl-1R,2R-Diaminocyclohexane

CBNumber:: CB7244380

Molecular Formula:: C8H18N2

Molecular Weight:: 142.24

MDL Number:: MFCD00671528

MOL File:: 87583-89-9.mol

MSDS File:: SDS

Last updated:2026-01-13 11:25:22

Product description	Number	Pack Size	Price
(S,S)-(+)-N,N′-Dimethyl-1,2-cyclohexanediamine ≥97.0% (GC)	669660	1g	$727
(1S,2S)-(+)-N,N'-Dimethylcyclohexane-1,2-diamine >98.0%(GC)	D2460	1g	$98
(1S,2S)-(+)-N,N'-Dimethylcyclohexane-1,2-diamine >98.0%(GC)	D2460	5g	$395
(1S,2S)-(+)-N,N'-Dimethylcyclohexane-1,2-diamine >98.0%(GC)	D2460	100mg	$27
(1S,2S)-(+)-N,N''-Dimethylcyclohexane-1,2-diamine	D456890	1g	$75
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(1S,2S)-N,N'-Dimethyl-1,2-cyclohexanediamine Properties

Melting point	39-44 °C
alpha	145 º (c=4.47 in chloroform)
Boiling point	186.8±8.0 °C(Predicted)
Density	0.902
refractive index	145 ° (C=4, CHCl3)
Flash point	74 °C
storage temp.	2-8°C
form	Solid
pka	11.04±0.40(Predicted)
color	Pale brown
optical activity	[α]/D +145±5°, c = 4.47 in chloroform
Water Solubility	Slightly soluble in water.
BRN	4304824
InChI	InChI=1S/C8H18N2/c1-9-7-5-3-4-6-8(7)10-2/h7-10H,3-6H2,1-2H3/t7-,8-/m0/s1
InChIKey	JRHPOFJADXHYBR-YUMQZZPRSA-N
SMILES	[C@H]1(NC)CCCC[C@@H]1NC
CAS DataBase Reference	87583-89-9(CAS DataBase Reference)
UNSPSC Code	12352116
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS05,GHS07

Signal word

Danger

Hazard statements

H302-H314

Precautionary statements

P260-P270-P280-P301+P312-P303+P361+P353-P305+P351+P338

PPE

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

Hazard Codes

Risk Statements

36/37/38-34-22

Safety Statements

26-36/37/39-45

RIDADR

UN 3259

WGK Germany

HazardClass

PackingGroup

Ⅱ

HS Code

29213000

Storage Class

8A - Combustible corrosive hazardous materials

Hazard Classifications

Acute Tox. 4 Oral
Skin Corr. 1B

NFPA 704

	0
3		0

(1S,2S)-N,N'-Dimethyl-1,2-cyclohexanediamine price More Price(34)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	669660	(S,S)-(+)-N,N′-Dimethyl-1,2-cyclohexanediamine ≥97.0% (GC)	87583-89-9	1g	$727	2023-06-20	Buy
TCI Chemical	D2460	(1S,2S)-(+)-N,N'-Dimethylcyclohexane-1,2-diamine >98.0%(GC)	87583-89-9	1g	$98	2025-07-31	Buy
TCI Chemical	D2460	(1S,2S)-(+)-N,N'-Dimethylcyclohexane-1,2-diamine >98.0%(GC)	87583-89-9	5g	$395	2025-07-31	Buy
TCI Chemical	D2460	(1S,2S)-(+)-N,N'-Dimethylcyclohexane-1,2-diamine >98.0%(GC)	87583-89-9	100mg	$27	2025-07-31	Buy
TRC	D456890	(1S,2S)-(+)-N,N''-Dimethylcyclohexane-1,2-diamine	87583-89-9	1g	$75	2021-12-16	Buy

Product number	Packaging	Price	Buy
669660	1g	$727	Buy
D2460	1g	$98	Buy
D2460	5g	$395	Buy
D2460	100mg	$27	Buy
D456890	1g	$75	Buy

(1S,2S)-N,N'-Dimethyl-1,2-cyclohexanediamine Chemical Properties,Uses,Production

Chemical Properties

Beige crystal

Uses

It is employed in the synthesis of 6-substituted 1-oxoindanoyl isoleucine conjugates and modeling studies with the coi1-jaz co-receptor complex of lima bean.

Uses

(S,S)-(+)-N,N′-Dimethyl-1,2-cyclohexanediamine can be used:

To synthesize derivatives of α-diazophosphonic acid, which are employed in O-H and N-H insertion reactions.
As a starting material for the synthesis of α-chloro-α-alkylphosphonic acids.
To prepare C2 symmetrical diamine enantiomers of C₆₀ with chirospectrosopic properties.

Synthesis

51066-08-1

74-89-5

61798-24-1

The reaction was catalyzed by 2.5 g of inorganic boric acid with epoxycyclohexane (98.2 g, 1.0 mol) and monomethylamine (35% aqueous solution, 1.0 mol) at 50 °C for 2 hours. After the reaction was completed, it was cooled to 0 °C, and 0% sulfuric acid solution (1.0 mol) was slowly added dropwise, controlling the temperature not to exceed 40 °C during the dropwise addition. Subsequently, the temperature was raised to 110 °C to remove water under atmospheric pressure until no water flowed out and the reaction system gradually became viscous. After the addition of 85 mL of cyclobutanesulfone, it was changed to vacuum distillation, and the temperature was gradually increased to 140 °C and maintained for 7-8 h until the moisture content was reduced to 0.38%. Cool the reaction solution to 0 ℃, dropwise add sodium hydroxide aqueous solution to adjust the pH to 12-13. slowly warmed to 75 ℃, the reaction solution gradually clarified, cooled to room temperature and separated the upper layer of liquid 81.9 g, GC purity of 95.2%, the yield of the first two steps was 70%. Add the upper liquid with 35% aqueous methylamine (1.12 mol) and 1.4g of inorganic boric acid into the autoclave, sealed and heated to 90 ℃ overnight, the reaction was completed (external standard yield of 96%). After cooling, the water and the pre-fraction were removed by distillation under reduced pressure to obtain pure N,N'-dimethyl-1,2-cyclohexanediamine. Combining the former fractions, a total of 88.6 g of colorless liquid with 89% yield was obtained, which was nearly white solid after cooling, and the GC purity was 99.2%.

References

[1] Patent: CN106478431, 2017, A. Location in patent: Paragraph 0011; 0012; 0013; 0014; 0015; 0016; 0017; 0018

(1S,2S)-N,N'-Dimethyl-1,2-cyclohexanediamine Preparation Products And Raw materials

Raw materials

7-Azabicyclo[4.1.0]heptane, 7-methyl- Methylamine Boric acid

Preparation Products

(1S,2S)-N,N'-Dimethyl-1,2-cyclohexanediamine Suppliers

Global( 201)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Shanghai UCHEM Inc.	+862156762820 +86-13564624040	sales@myuchem.com	China	8731	58
Capot Chemical Co.,Ltd.	+86-（0）57185586718; +8613336195806	sales@capot.com	China	29735	60
Shanghai Daken Advanced Materials Co.,Ltd	+86-2158073036	info@dakenam.com	China	13799	58
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29831	58
Jinan Carbotang Biotech Co.,Ltd.	+8615866703830	figo.gao@foxmail.com	China	8497	58
Accela ChemBio Inc.	+1-858-6993322	info@accelachem.com	United States	21193	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49977	58
SIMAGCHEM CORP	+86-5922680277 +86-13806087780	sale@simagchem.com	China	17346	58
Win-Win chemical CO., Limited	+86-0086-577-64498589 +86-15355981851	sales@win-winchemical.com	China	14343	58

Supplier	Advantage
Shanghai UCHEM Inc.	58
Capot Chemical Co.,Ltd.	60
Shanghai Daken Advanced Materials Co.,Ltd	58
career henan chemical co	58
Jinan Carbotang Biotech Co.,Ltd.	58
Accela ChemBio Inc.	58
Alchem Pharmtech,Inc.	58
CONIER CHEM AND PHARMA LIMITED	58
SIMAGCHEM CORP	58
Win-Win chemical CO., Limited	58

View Lastest Price from (1S,2S)-N,N'-Dimethyl-1,2-cyclohexanediamine manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-02-11	(1S,2S)-N,N'-Dimethyl-1,2-cyclohexanediamine 87583-89-9	US $52.00-119.00 / g	5g	0.98	100kg	Shanghai UCHEM Inc.
2024-03-28	(1S,2S)-N,N'-Dimethyl-1,2-cyclohexanediamine 87583-89-9	US $0.00 / KG	25KG	95%	Inquiry	PNP Biotech Co. Ltd
2019-07-06	(1S,2S)-N,N'-Dimethyl-1,2-cyclohexanediamine 87583-89-9	US $1.00 / KG	1KG	99%	Customized	Career Henan Chemical Co

(1S,2S)-N,N'-Dimethyl-1,2-cyclohexanediamine
87583-89-9
US $52.00-119.00 / g
0.98
Shanghai UCHEM Inc.

(1S,2S)-N,N'-Dimethyl-1,2-cyclohexanediamine
87583-89-9
US $0.00 / KG
95%
PNP Biotech Co. Ltd

(1S,2S)-N,N'-Dimethyl-1,2-cyclohexanediamine
87583-89-9
US $1.00 / KG
99%
Career Henan Chemical Co

(1S,2S)-N,N'-Dimethyl-1,2-cyclohexanediamine Spectrum

(1S,2S)-N,N'-Dimethyl-1,2-cyclohexanediamine(87583-89-9)¹HNMR

87583-89-9((1S,2S)-N,N'-Dimethyl-1,2-cyclohexanediamine)Related Search:

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Bromadoline U-62066 (SPIRADOLINE MESYLATE) K-OPIOID AGONIST (1S,2S)-N,N,N''N''-TETRAMETHYL-1,2-CYCLOHEXANEDIAMINE

1of4

TRANS-(1S,2S)-N,N'-BISMETHYL-1,2-CYCLOHEXANE-DIAMINE (1S,2S)-N,N'-BISMETHYL-1,2-CYCLOHEXANE-DIAMINE (1S,2S)-(+)-1,2-BIS(METHYLAMINO)CYCLOHEXANE Dimethylcyclohexanediamine (1S)-trans-1,2-Bis(methylamino)cyclohexane, (S,S)-N,Nμ-Dimethyl-1,2-diaminocyclohexane (S,S)-(+)-N,Nμ-Dimethyl-1,2-cyclohexanediamine (1S,2S)-(+)-N,N'-Dimethylcyclohexane-1,2-diamine,98% (1S,2S)-N,N'-Dimethyl-1,2-cyclohexanediamine (S,S)-N,N'-Dimethyl-1,2-diaminocyclohexane N,N'-Dimethyl-1R,2R-Diaminocyclohexane 2-cyclohexane-diaMine 2S)-N N\'-BisMethyl-1 N,N'-Dimethyl-(1S,2S)-1,2-Cyclohexanediamine 1,2-Cyclohexanediamine, N1,N2-dimethyl-, (1S,2S)- (S,S)-(+)-N,N (S,S)-(+)-N,N'-Dimethyl-1,2-cyclohexanediamine >=97.0% (GC) (1S,2S)-(+)-trans-1,2-Bis(methylamino)cyclohexane (1S,2S)-N,N'-Dimethyl-1,2-cyc (S,S)-N,N'-Dimethyl-1,2-diaminocyclohex (S,S)-N,N'-Dimethyl-1,2-diaminocyclohexane (Oxaliplatin) (1,2,S)-(+)-N,N-DIMETHYLCYCLOHEXANE-1,2-DIAMINE (1S,2S)-(+)-N,N'-Dimethylcyclohexane-1,2-diamine> (1S,2S)-(+)-N,N'-DimethyL ohexane-1,2-diamine (1S,2S)-N1,N2-Dimethyl-1,2-cyclohexanediamine (1S,2S)-N,N'-Dimethylcyclohexane-1,2-diamine TRANS-(1S,2S)-N,N'-BISMETHYL-1,2-CYCLOHEXANEDIAMINE (1S,2S)-N,N'-Dimethyl-1,2-diaminocyclohexane (S,S)-(+)-N,N′-Dimethyl-1,2-cyclohexanediamine (1S,2S)-(+)-N,N' (S,S)-(+)-N,N′-Dimethyl-1,2-cyclohexanediamine, CAS 87583-89-9 (1S,2S)-(+)-N,N'-dimethyl-1,2-cyclohexyldiamine 87583-89-9 Enantiomer Excess & Absolute Conefiguration Determination e.e. / Absolute Conefiguration Determination (NMR) Chiral Building Blocks Amines (Chiral) Chiral Nitrogen DACH&Trost Series Isoquinolines ,Quinolines ,Quinaldines API intermediates Amines (Chiral) Analytical Chemistry Chiral Building Blocks e.e. / Absolute Configuration Determination (NMR) Enantiomer Excess & Absolute Configuration Determination Synthetic Organic Chemistry