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(1S,2S)-N,N'-Dimethyl-1,2-cyclohexanediamine

(1S,2S)-N,N'-Dimethyl-1,2-cyclohexanediamine structure

CAS No.: 87583-89-9

Chemical Name:: (1S,2S)-N,N'-Dimethyl-1,2-cyclohexanediamine

Synonyms: (1S,2S)-N,N'-Dimethyl-1,2-diaminocyclohexane;(1S,2S)-N1,N2-Dimethyl-1,2-cyclohexanediamine;Dimethylcyclohexanediamine;2S)-N;(S,S)-(+)-N,N;N\'-BisMethyl-1;ohexane-1,2-diamine;(1S,2S)-(+)-N,N'2-cyclohexane-diaMine;(1S,2S)-(+)-N,N'-DimethyL

CBNumber:: CB7244380

Molecular Formula:: C8H18N2

Molecular Weight:: 142.24

MDL Number:: MFCD00671528

MOL File:: 87583-89-9.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-05-28 02:25:55

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(1S,2S)-N,N'-Dimethyl-1,2-cyclohexanediamine Properties

Melting point	39-44 °C
alpha	145 º (c=4.47 in chloroform)
Boiling point	186.8±8.0 °C(Predicted)
Density	0.902
refractive index	145 ° (C=4, CHCl3)
Flash point	74 °C
storage temp.	2-8°C
form	Solid
pka	11.04±0.40(Predicted)
color	Pale brown
optical activity	[α]/D +145±5°, c = 4.47 in chloroform
Water Solubility	Slightly soluble in water.
BRN	4304824
InChI	InChI=1S/C8H18N2/c1-9-7-5-3-4-6-8(7)10-2/h7-10H,3-6H2,1-2H3/t7-,8-/m0/s1
InChIKey	JRHPOFJADXHYBR-YUMQZZPRSA-N
SMILES	[C@H]1(NC)CCCC[C@@H]1NC
CAS DataBase Reference	87583-89-9(CAS DataBase Reference)
UNSPSC Code	12352116
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS05,GHS07

Signal word

Danger

Hazard statements

H302-H314

Precautionary statements

P260-P270-P280-P301+P312-P303+P361+P353-P305+P351+P338

PPE

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

Hazard Codes

Risk Statements

36/37/38-34-22

Safety Statements

26-36/37/39-45

RIDADR

UN 3259

WGK Germany

HazardClass

PackingGroup

Ⅱ

HS Code

29213000

Storage Class

8A - Combustible corrosive hazardous materials

Hazard Classifications

Acute Tox. 4 Oral
Skin Corr. 1B

NFPA 704

	0
3		0

(1S,2S)-N,N'-Dimethyl-1,2-cyclohexanediamine price More Price(62)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	669660	(S,S)-(+)-N,N′-Dimethyl-1,2-cyclohexanediamine ≥97.0% (GC)	87583-89-9	1g	$727	2023-06-20	Buy
TCI Chemical	D2460	(1S,2S)-(+)-N,N'-Dimethylcyclohexane-1,2-diamine >98.0%(GC)	87583-89-9	1g	$85	2026-04-30	Buy
TCI Chemical	D2460	(1S,2S)-(+)-N,N'-Dimethylcyclohexane-1,2-diamine >98.0%(GC)	87583-89-9	5g	$344	2026-04-30	Buy
Usbiological	273471	N,N'-Dimethyl-(1S,2S)-1,2-Cyclohexanediamine Asreported	87583-89-9	1g	$319	2026-06-03	Buy
Usbiological	273471	N,N'-Dimethyl-(1S,2S)-1,2-Cyclohexanediamine Asreported	87583-89-9	2g	$446	2026-06-03	Buy

Product number	Packaging	Price	Buy
669660	1g	$727	Buy
D2460	1g	$85	Buy
D2460	5g	$344	Buy
273471	1g	$319	Buy
273471	2g	$446	Buy

(1S,2S)-N,N'-Dimethyl-1,2-cyclohexanediamine Chemical Properties, Uses, Production

Chemical Properties

Beige crystal

Uses

It is employed in the synthesis of 6-substituted 1-oxoindanoyl isoleucine conjugates and modeling studies with the coi1-jaz co-receptor complex of lima bean.

Uses

(S,S)-(+)-N,N′-Dimethyl-1,2-cyclohexanediamine can be used:

To synthesize derivatives of α-diazophosphonic acid, which are employed in O-H and N-H insertion reactions.
As a starting material for the synthesis of α-chloro-α-alkylphosphonic acids.
To prepare C2 symmetrical diamine enantiomers of C₆₀ with chirospectrosopic properties.

Synthesis

51066-08-1

74-89-5

61798-24-1

The reaction was catalyzed by 2.5 g of inorganic boric acid with epoxycyclohexane (98.2 g, 1.0 mol) and monomethylamine (35% aqueous solution, 1.0 mol) at 50 °C for 2 hours. After the reaction was completed, it was cooled to 0 °C, and 0% sulfuric acid solution (1.0 mol) was slowly added dropwise, controlling the temperature not to exceed 40 °C during the dropwise addition. Subsequently, the temperature was raised to 110 °C to remove water under atmospheric pressure until no water flowed out and the reaction system gradually became viscous. After the addition of 85 mL of cyclobutanesulfone, it was changed to vacuum distillation, and the temperature was gradually increased to 140 °C and maintained for 7-8 h until the moisture content was reduced to 0.38%. Cool the reaction solution to 0 ℃, dropwise add sodium hydroxide aqueous solution to adjust the pH to 12-13. slowly warmed to 75 ℃, the reaction solution gradually clarified, cooled to room temperature and separated the upper layer of liquid 81.9 g, GC purity of 95.2%, the yield of the first two steps was 70%. Add the upper liquid with 35% aqueous methylamine (1.12 mol) and 1.4g of inorganic boric acid into the autoclave, sealed and heated to 90 ℃ overnight, the reaction was completed (external standard yield of 96%). After cooling, the water and the pre-fraction were removed by distillation under reduced pressure to obtain pure N,N'-dimethyl-1,2-cyclohexanediamine. Combining the former fractions, a total of 88.6 g of colorless liquid with 89% yield was obtained, which was nearly white solid after cooling, and the GC purity was 99.2%.

References

[1] Patent: CN106478431, 2017, A. Location in patent: Paragraph 0011; 0012; 0013; 0014; 0015; 0016; 0017; 0018

(1S,2S)-N,N'-Dimethyl-1,2-cyclohexanediamine Preparation Products And Raw materials

Raw materials

7-Azabicyclo[4.1.0]heptane, 7-methyl- Methylamine Boric acid

Preparation Products

(1S,2S)-N,N'-Dimethyl-1,2-cyclohexanediamine Suppliers

Global Suppliers ( 200)

Supplier	Tel	Email	Country	ProdList	Advantage
Chengdu Forest Science and Technology Development Co., Ltd.	18030648795 18030648795	sales@cdforestchem.com	China	1998	58
Shanghai Moss Medicine Technology Co., Ltd.	+86-188369842 +86-15618151133	188369842@qq.com	China	1965	58
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	4006356688 18621169109	market03@meryer.com	China	40202	62
Alfa Aesar	400-6106006	saleschina@alfa-asia.com	China	30103	84
TCI (Shanghai) Development Co., Ltd.	021-67121386	Sales-CN@TCIchemicals.com	China	24512	81
ShangHai DEMO Chemical Co.,Ltd	400-021-7337 2355568890	sales@demochem.com	China	2569	57
Beijing HwrkChemical Technology Co., Ltd	89508211 18501085097	sales.bj@hwrkchemical.com	China	9407	55
Energy Chemical	400-0056266	sales8178@energy-chemical.com	China	44850	61
Shijiazhuang Sdyano Fine Chemical Co., Ltd.	0311-89250318 13582355795	master@sjzsdyn.com	China	2776	65

Supplier	Advantage
Chengdu Forest Science and Technology Development Co., Ltd.	58
Shanghai Moss Medicine Technology Co., Ltd.	58
J & K SCIENTIFIC LTD.	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	62
Alfa Aesar	84
TCI (Shanghai) Development Co., Ltd.	81
ShangHai DEMO Chemical Co.,Ltd	57
Beijing HwrkChemical Technology Co., Ltd	55
Energy Chemical	61
Shijiazhuang Sdyano Fine Chemical Co., Ltd.	65

View Latest Price from (1S,2S)-N,N'-Dimethyl-1,2-cyclohexanediamine manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-09-16	(1S,2S)-N,N'-Dimethyl-1,2-cyclohexanediamine 87583-89-9	$52.00-119.00	5g	0.98	100kg	Shanghai UCHEM Inc.
2024-03-28	(1S,2S)-N,N'-Dimethyl-1,2-cyclohexanediamine 87583-89-9		25KG	95%		PNP Biotech Co. Ltd
2019-07-06	(1S,2S)-N,N'-Dimethyl-1,2-cyclohexanediamine 87583-89-9	$1.00	1KG	99%		Career Henan Chemical Co

(1S,2S)-N,N'-Dimethyl-1,2-cyclohexanediamine
87583-89-9
$52.00-119.00
0.98
Shanghai UCHEM Inc.

(1S,2S)-N,N'-Dimethyl-1,2-cyclohexanediamine
87583-89-9
$0.00
95%
PNP Biotech Co. Ltd

(1S,2S)-N,N'-Dimethyl-1,2-cyclohexanediamine
87583-89-9
$1.00
99%
Career Henan Chemical Co

(1S,2S)-N,N'-Dimethyl-1,2-cyclohexanediamine Spectrum

(1S,2S)-N,N'-Dimethyl-1,2-cyclohexanediamine(87583-89-9)¹HNMR

87583-89-9 ((1S,2S)-N,N'-Dimethyl-1,2-cyclohexanediamine) Related Search:

(+/-)-trans-1,2-Diaminocyclohexane 1,2-Diaminocyclohexane trans-1,4-Diaminocyclohexane Dimethyl phthalate Dimethyl fumarate

Dimethyl ether Dimethyl sulfide 1,2-Cyclohexanedione 1,2-Cyclohexylenedinitrilotetraacetic acid Hexamethylenediamine

Dimethyl sulfoxide N,N-Dimethylformamide Ethane Bromadoline U-69593

Enadoline U-62066 (SPIRADOLINE MESYLATE) K-OPIOID AGONIST Trans-(1R,2R)N,N'-Dimethyl-cyclohexane-1,2-diamine

1of4

TRANS-(1S,2S)-N,N'-BISMETHYL-1,2-CYCLOHEXANE-DIAMINE (1S,2S)-N,N'-BISMETHYL-1,2-CYCLOHEXANE-DIAMINE (1S,2S)-(+)-1,2-BIS(METHYLAMINO)CYCLOHEXANE (1S)-trans-1,2-Bis(methylamino)cyclohexane, (S,S)-N,Nμ-Dimethyl-1,2-diaminocyclohexane (S,S)-(+)-N,Nμ-Dimethyl-1,2-cyclohexanediamine (1S,2S)-(+)-N,N'-Dimethylcyclohexane-1,2-diamine,98% (1S,2S)-N,N'-Dimethyl-1,2-cyclohexanediamine (S,S)-N,N'-Dimethyl-1,2-diaminocyclohexane N,N'-Dimethyl-1R,2R-Diaminocyclohexane 2-cyclohexane-diaMine 2S)-N N\'-BisMethyl-1 N,N'-Dimethyl-(1S,2S)-1,2-Cyclohexanediamine 1,2-Cyclohexanediamine, N1,N2-dimethyl-, (1S,2S)- (S,S)-(+)-N,N (S,S)-(+)-N,N'-Dimethyl-1,2-cyclohexanediamine >=97.0% (GC) (1S,2S)-(+)-trans-1,2-Bis(methylamino)cyclohexane (1S,2S)-N,N'-Dimethyl-1,2-cyc (S,S)-N,N'-Dimethyl-1,2-diaminocyclohex (S,S)-N,N'-Dimethyl-1,2-diaminocyclohexane (Oxaliplatin) (1,2,S)-(+)-N,N-DIMETHYLCYCLOHEXANE-1,2-DIAMINE (1S,2S)-(+)-N,N'-Dimethylcyclohexane-1,2-diamine> (1S,2S)-(+)-N,N'-DimethyL ohexane-1,2-diamine (1S,2S)-N,N'-Dimethylcyclohexane-1,2-diamine TRANS-(1S,2S)-N,N'-BISMETHYL-1,2-CYCLOHEXANEDIAMINE (S,S)-(+)-N,N′-Dimethyl-1,2-cyclohexanediamine (1S,2S)-(+)-N,N' (S,S)-(+)-N,N′-Dimethyl-1,2-cyclohexanediamine, CAS 87583-89-9 (1S,2S)-(+)-N,N'-dimethyl-1,2-cyclohexyldiamine (1S,2S)-N1,N2-Dimethyl-1,2-cyclohexanediamine (1S,2S)-N,N'-Dimethyl-1,2-diaminocyclohexane Dimethylcyclohexanediamine trans-(1S,2S)-N,N'-Dimethyl-1,2-cyclohexanediamine 87583-89-9 Enantiomer Excess & Absolute Conefiguration Determination e.e. / Absolute Conefiguration Determination (NMR) Chiral Building Blocks Amines (Chiral) Chiral Nitrogen DACH&Trost Series Isoquinolines ,Quinolines ,Quinaldines API intermediates Amines (Chiral) Analytical Chemistry Chiral Building Blocks e.e. / Absolute Configuration Determination (NMR) Enantiomer Excess & Absolute Configuration Determination Synthetic Organic Chemistry